Abstract:A total of 102 women with recurrent urinary tract infections were included in this open randomized study; 55 received 200 mg of norfloxacin daily and 47 received 50 mg of nitrofurantoin daily over 6 months. Fifty-three and 41 women from the norfloxacin-and nitrofurantoin-treated groups, respectively, completed the 6-month follow-up period. Forty-four (81%) of the norfloxacin-treated patients and 27 (65%) of the nitrofurantointreated patients remained free of symptoms (P = 0.05), and urine samples from 49 (92.4… Show more
Differences in safety, antimicrobial spectrum of activity, and resistance development support the selective use of various fluoroquinolones in differing clinical situations.
Differences in safety, antimicrobial spectrum of activity, and resistance development support the selective use of various fluoroquinolones in differing clinical situations.
“…Cephalosporins are not well documented for prophylaxis. Chinolones, like norfloxacin, demonstrate a satisfying prophylactic effect in adults but are not yet approved for use in children (14).…”
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