Long-term prognostic benefit of adjuvant chemotherapy for patients with hepatoid adenocarcinoma of the stomach after radical resection: A national multicenter study

Huang, Ze-Ning; Huang, Yingqi; Hong, Qingqi; Zhang, Peng; Zhang, Zizhen; He, Liang; Shang, Liang; Wang, Linjun; Sun, Yeqing; Li, Zhixiong; Liu, Jun-Jie; Ding, Fanghui; Lin, Ende; Fu, Yongan; Lin, Shuangming; Lü, Jun; Zheng, Chao‐Hui; Huang, Chang‐Ming; Li, Ping

doi:10.1016/j.ejso.2023.07.001

Cited by 4 publications

(2 citation statements)

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“…Currently, timely detection and complete surgical resection are considered vital treatment strategies. Accurate differentiation between hepatocellular carcinoma and liver metastases of HAC is essential [8]. Due to the low incidence of HAC, few domestic reports, and the specificity of the clinical and imaging features of patients is not high, it is not easy to predict the prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Development of dynamic nomogram for predicting cancer-specific survival in hepatoid adenocarcinoma: A comprehensive SEER-based population analysis

Wang,

Zhou,

et al. 2024

Biomol Biomed

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Hepatoid adenocarcinoma (HAC) is a poorly differentiated extrahepatic tumor that can produce alpha-fetoprotein (AFP). The literature does not provide a comprehensive understanding of the prognostic factors for HAC. Therefore, we present a novel nomogram to predict the cancer-specific survival (CSS) of patients with HAC. We analyzed 265 cases of HAC from the Surveillance, Epidemiology, and End Results (SEER) database spanning from 2004 to 2015. Using a Cox proportional hazard regression model, we identified several risk factors and incorporated them into our predictive nomogram. The nomogram's predictive ability was assessed by utilizing the concordance index (c-index), calibration curve, and receiver operating characteristic (ROC). Results from a multivariate Cox regression showed that CSS was independently correlated with liver metastasis, surgery, and chemotherapy. Our nomogram, which has a c-index of 0.71 (95% CI 0.71-0.96) is available at https://april-1998.shinyapps.io/dynamic_nomogram/. Furthermore, calibration curves demonstrated concordance between the predicted survival probability from the nomogram and the observed survival probability. The areas under the curve (AUC) for 6-month, 1-, and 3-year survival were 0.80, 0.82, and 0.88, respectively. Our study successfully formulated a prognostic nomogram that offers promising predictions for the 6-month, 1-, and 3-year CSS of patients with HAC. This nomogram holds potential for practical use in guiding treatment decisions and designing clinical trials.

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Section: Discussionmentioning

confidence: 99%

“…Previous research has demonstrated surgical resection as the primary treatment for HAC, whereas recurrence still may happen after R0 resection [8]. Generally, the current American Joint Committee on Cancer (AJCC) staging systems for various cancers were recognized as standard evaluating systems for predicting patients' survival.…”

Section: Introductionmentioning

confidence: 99%