Long-Term Prognosis of Quality of Life in Dogs Diagnosed With Mild to Moderate Elbow Dysplasia in Sweden

Bergström, Annika; Johard, Sofia; Lee, Marcel H.; Comin, Arianna

doi:10.3389/fvets.2020.572691

Cited by 6 publications

(17 citation statements)

References 31 publications

(40 reference statements)

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“…Dingoes arrived in Australia between 4,000 and 11,000 years ago, and their ancestors probably originated in Asia (Savolainen, et al 2004; Cairns and Wilton 2016; Balme, et al 2018; Bergstrom, et al 2020; Zhang, et al 2020). While their taxonomic status and evolutionary history remain contested, studies demonstrate their important ecological role as Australia’s largest terrestrial top-order predator (Johnson, et al 2007; Wallach, et al 2010; Letnic, et al 2012) and also their cultural significance, particularly for First Nations Peoples (Corbett 2001; Archer-Lean, et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Genomic signatures of bottleneck and founder effects in dingoes

Kumar

Conroy

Ogbourne

et al. 2023

Preprint

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Dingoes arrived in Australia during the mid-Holocene and are the native top order terrestrial predator on the mainland and some offshore islands. Although dingoes subsequently spread across the continent, the initial founding population(s) could have been small. To investigate this hypothesis, we examined the potential signatures of bottlenecks and founder effects in dingoes by sequencing the whole genomes of three dingoes and also obtaining the genome data from nine additional dingoes and 56 canines, including wolves, village dogs and breed dogs, and examined the signatures of bottlenecks and founder effects. We found that the nucleotide diversity of dingoes was low, and 36% less than highly inbred breed dogs and 3.3 times lower than wolves. The number of runs of homozygosity (RoH) segments in dingoes was 1.6 to 4.7 times higher than in other canines. Whilst examining deleterious mutational load, we observed that dingoes carried elevated ratios of nonsynonymous to synonymous diversities, significantly higher numbers of homozygous deleterious Single Nucleotide Variants (SNVs), and increased numbers of loss of function SNVs, compared to breed dogs, village dogs, and wolves. These results suggest dingoes experienced a severe bottleneck, potentially caused by the limited number of founding individuals. While many studies observe less diversity and a higher number of deleterious mutations in domesticated populations compared to their wild relatives, we observed the opposite .i.e. wild dingoes have lower diversity and a greater number of harmful mutations than domesticated dogs. Our findings can be explained by bottlenecks and founder effects during the establishment of dingoes on mainland Australia. These findings highlight the need for conservation-based management of dingoes and need for wildlife managers to be cognisant of these findings when considering the use of lethal control measures across the landscape.

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Section: Introductionmentioning

confidence: 99%

Genomic signatures of bottleneck and founder effects in dingoes

Kumar

Conroy

Ogbourne

et al. 2023

Preprint

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“…By contrast, in dogs with elbow dysplasia there is a strong link between COI lameness and quality of life scores. 35 It may be that the lameness here was more mechanical than painful, hence the owner's perception of good quality of life. Case 3's FMPI score suggests the cat returned to normal in every respect.…”

Section: Discussionmentioning

confidence: 97%

Bioengineering an Osteoinductive Treatment for Bone Healing Disorders: A Small Animal Case Series

et al. 2023

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The aim of this article was to study clinical and radiographic outcomes following treatment of bone healing disorders with a novel osteoinductive system that utilizes poly (ethyl acrylate), fibronectin and an ultra-low concentration of recombinant human bone morphogenetic protein-2. A case series of nine dogs and two cats were treated, and clinical records and radiographs were reviewed. Radiographs were scored by two blinded observers using the modified Radiographic Union Score for Tibial Fractures. Long-term follow-up was obtained using the Canine Orthopaedic Index and Feline Musculoskeletal Pain Index. Follow-up data were available for 11 treatments (10 cases). Complications: three minor, three major, one catastrophic (non-union requiring amputation). Lameness median 320 (range: 42–1,082) days postoperatively: ‘sound’ (three cases), ‘subtle’ (two), ‘mild’ (three), ‘moderate’ (one), and ‘non-weightbearing’ (one). The attending clinician judged 9 of 11 treatments achieved radiographic union; modified Radiographic Union Score for Tibial Fractures observers 1 and 2 agreed with the clinician in 8/9 and 5/9 treatments respectively. Long-term Canine Orthopaedic Index scores for five dogs median 650 (range: 544–1,724) days postoperatively: 15/64 (median) for four dogs with acceptable outcomes, 30/64 in one dog with a poor outcome. Feline Musculoskeletal Pain Index scores for two cats 433 and 751 days postoperatively: 48/60 and 60/60. Eight of 10 cases were sound or showed subtle or mild lameness in the short- or long-term, and radiographic union occurred in the majority of treatments.

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“…The standardised scores were dichotomised as follows: a score of 0.2 was considered good, and a score greater than 0.2 was considered poor. 32 The standardised score for Q1 was subtracted from the standardised score for Q2 for each category to evaluate deterioration during the follow-up period. The resulting difference was dichotomised as 'same/better' (same standardised score or improvement from Q1 to Q2) or 'worse' (deterioration from Q1 to Q2).…”

Section: Discussionmentioning

confidence: 99%

“…The results from this study have been published previously. 32 To evaluate the long-term outcome of ED, the participants from the Q1 study were contacted again at least 2 years after the first interview and asked to participate in the web-based Q2 study.…”

Section: Study Design and Questionnairementioning

confidence: 99%

“…In a previous study, we used Bayesian network analysis to report on the long-term prognosis for quality of life in a cohort of dogs, not primarily seeking veterinary care, diagnosed with mild and moderate OA through an ED screening programme. 32 The present study aimed to report the long-term owner-assessed outcome of ED and survival in the same cohort of dogs. Additionally, risk factors for the worsening of the COI score over time were evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term outcomes in dogs with elbow dysplasia, assessed using the canine orthopaedic index

Obel¹,

Bergström

Comin

et al. 2023

Veterinary Record

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BackgroundElbow dysplasia (ED) is an important cause of lameness in dogs. This study aimed to report long‐term outcomes in dogs with elbow osteoarthritis.MethodsDemographic data, medical management, and scores from The American College of Veterinary Surgeons' Canine Orthopaedic Index (COI) were collected from owners of dogs radiographically screened for ED, graded as normal, mild, or moderate. Telephone interviews were performed in 2017 (Q1), followed by an email survey in 2020 (Q2). The association between ED grade and deterioration in COI scores over time was evaluated with logistic regression.ResultsA total of 765 replies were collected for Q1 and 293 for Q2. At Q2, 222 dogs (76%) were alive, with a median age of 8 years (range 5–12 years). No association was found between ED and changes in COI score over time or between ED and survival (p = 0.071). Dogs with mild and moderate ED were treated with analgesic medications to a higher degree than dogs without ED (p < 0.05).LimitationsOnly owner‐assed data were assessed; no clinical orthopaedic examination or follow‐up radiographic evaluation was performed.ConclusionsNo association was found between the grade of ED and the worsening of clinical signs in dogs with elbow osteoarthritis.

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Long-Term Prognosis of Quality of Life in Dogs Diagnosed With Mild to Moderate Elbow Dysplasia in Sweden

Abstract: The objective of this study was to increase knowledge regarding long-term prognosis of mild to moderate elbow dysplasia (ED) using a canine orthopedic index.

Cited by 6 publications

References 31 publications

Genomic signatures of bottleneck and founder effects in dingoes

Genomic signatures of bottleneck and founder effects in dingoes

Bioengineering an Osteoinductive Treatment for Bone Healing Disorders: A Small Animal Case Series

Long‐term outcomes in dogs with elbow dysplasia, assessed using the canine orthopaedic index

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