Long‐Term Prognosis of Patients with Biliary Atresia: A 25 Year Summary

Hung, Peiyin; Chen, Chiu-Chiang; Chen, Wei-Jao; Lai, Hong‐Shiee; Hsu, Wen-Ming; Lee, Po‐Huang; Ho, Ming-Chih; Chen, Chien-Jen; Ni, Yen‐Hsuan; Chen, Huey‐Ling; Hsu, Hong–Yuan; Chang, Mei–Hwei

doi:10.1097/01.mpg.0000189339.92891.64

Cited by 137 publications

(114 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15 Median age at surgery in our series was 80.5 days, higher than both older series (61 to 69 days) 16,17 and more recent ones (54 to 68 days). 5,14,[18][19][20][21] Only the average PE age of the Thailand series (90.3±36.4 days) was similar to that found in the present study (93.7±51.3 days).…”

supporting

confidence: 77%

“…Performing PE enables a survival period which can go beyond 20 years for 20% of patients. 20,22 were seen in Japan. 14 Survival periods for patients in our study who did not require transplantation were lower than those mentioned above, at 24 and 15% after 10 and 20 years, respectively.…”

mentioning

confidence: 99%

“…3,5,[14][15][16][17][18][19][20][21][22] The presence of uncompensated cirrhosis or malformations in other organs which could rule out surgery. 3,22 Nine patients over three months old and with advanced hepatic failure were not submitted to PE.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Atresia biliar: continuamos operando tarde

Kieling¹,

Santos²,

Vieira³

et al. 2008

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

show abstract

supporting

confidence: 77%

mentioning

confidence: 99%

See 1 more Smart Citation

Atresia biliar: continuamos operando tarde

Kieling¹,

Santos²,

Vieira³

et al. 2008

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

show abstract

“…8 El diagnóstico y el tratamiento tempranos de la atresia biliar, antes del mes y medio de vida, se asocian a un mejor pronóstico. 3,9 La toxoplasmosis congénita es una causa rara de colestasis neonatal. La infección congénita se produce después de una infección primaria materna; con mayor riesgo de transmisión en el tercer trimestre, pero mayor riesgo de infección congénita grave cuando la transmisión es entre las 10 y las 24 semanas de gestación.…”

Section: Discussionunclassified

Colestasis neonatal por toxoplasmosis congénita. A propósito de un caso clínico

2013

View full text Add to dashboard Cite

Arch Argent Pediatr 2013;111(4):e105-e108 / e105Presentación de casos clínicos RESUMEN La colestasis neonatal es la forma de presentación de diversas enfermedades; es necesario un diagnóstico etiológico temprano, ya que el tratamiento antes de los 60 días de vida cambia el pronóstico en los niños que presentan atresia biliar. La toxoplasmosis congénita puede ser asintomática en el recién nacido, o presentar fundamentalmente alteraciones neuroló-gicas, oftalmológicas y hepáticas (hepatomegalia, ictericia no colestásica). La colestasis neonatal secundaria a toxoplasmosis congénita no es una situación informada con frecuencia. Se presenta el caso de un lactante con colestasis neonatal cuya etiología responde a una toxoplasmosis congénita, con el objetivo de discutir las dificultades en establecer el diagnóstico etiológico y las indicaciones de realizar estudios invasivos, como la biopsia hepática, en estas situaciones. Palabras clave: colestasis neonatal, toxoplasmosis, ictericia neonatal, atresia biliar. SUMMARYNeonatal cholestasis is the manifestation of many different diseases. Its early etiological diagnosis is crucial, since treatment before 60 days of life changes the prognosis in children with biliary atresia. Congenital toxoplasmosis can be asymptomatic in the newborn, or have mainly neurological, ophthalmological or gastrointestinal symptoms (hepatomegaly, cholestatic jaundice). Neonatal cholestasis secondary to congenital toxoplasmosis is not a situation frequently reported. We report the case of an infant with neonatal cholestasis due to a congenital toxoplasmosis, in order to discuss the difficulties in establishing the etiological diagnostic and to review the indications of invasive studies such as liver biopsy in these situations.

show abstract

“…Portoenterostomy is typically performed as soon as possible in these children [3,4] . However, liver cirrhosis and its complications may develop in some patients even after a successful porto-enterostomy.…”

Section: Introductionmentioning

confidence: 99%

Macro-regenerative nodules in biliary atresia: CT/MRI findings and their pathological relations

Liang¹,

Cheng²,

Concejero³

et al. 2008

WJG

View full text Add to dashboard Cite

AIM:To describe the radiological findings of a macro-regenerative nodule (MRN) in the liver of pretransplantation biliary atresia (BA) patients and to correlate it with histological findings. METHODS: Between August 1990 and November 2007, 144 BA patients underwent liver transplantation (LT) at our institution. The pre-transplantation computer tomography (CT) and magnetic resonance imaging (MRI) findings were reviewed and correlated with the post-transplantation pathological findings. RESULTS: Nine tumor lesions in 7 patients were diagnosed in explanted livers. The post-transplantation pathological findings showed that all the lesions were MRNs without malignant features. No small nodule was detected by either MRI or CT. Of the 8 detectable lesions, 6 (75%) were in the central part of the liver, 5 (63%) were larger than 5 cm, 5 (63%) had intratumor tubular structures, 3 (38%) showed enhancing fibrous septa, 3 (38%) had arterial enhancement in CT, one (13%) showed enhancement in MRI, and one (13%) had internal calcifications. CONCLUSION: Although varied in radiological a p p e a ra n c e , M R N c a n b e d i f f e r e n t i a t e d f r o m hepatocellular carcinoma (HCC) in most of BA patients awaiting LT. The presence of an arterial-enhancing nodule does not imply that LT is withheld solely on the basis of presumed malignancy by imaging studies. Liver biopsy may be required in aid of diagnostic imaging to exclude malignancy.

show abstract

Long‐Term Prognosis of Patients with Biliary Atresia: A 25 Year Summary

Cited by 137 publications

References 19 publications

Atresia biliar: continuamos operando tarde

Atresia biliar: continuamos operando tarde

Colestasis neonatal por toxoplasmosis congénita. A propósito de un caso clínico

Macro-regenerative nodules in biliary atresia: CT/MRI findings and their pathological relations

Contact Info

Product

Resources

About