Long-Term Prognosis of Patients With Takotsubo Syndrome

Ghadri, Jelena R.; Kato, Ken; Cammann, Victoria L.; Gili, Sebastiano; Jurisic, Stjepan; Vece, Davide Di; Candreva, Alessandro; Ding, Katharina J.; Micek, Jozef; Szawan, Konrad A.; Bacchi, Beatrice; Bianchi, Rahel; Levinson, Rena A.; Wischnewsky, Manfred; Seifert, Burkhardt; Schlossbauer, Susanne Anna; Citro, Rodolfo; Bossone, Eduardo; Münzel, Thomas; Knorr, Maike; Heiner, Susanne; D’Ascenzo, Fabrizio; Franke, Jennifer; Sarcon, Annahita; Napp, L. Christian; Jaguszewski, Miłosz; Noutsias, Michel; Katus, Hugo A.; Burgdorf, Christof; Schunkert, Heribert; Thiele, Holger; Bauersachs, Johann; Tschöpe, Carsten; Pieske, Burkert; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Hasenfuß, Gerd; Karakas, Mahir; Köenig, Wolfgang; Rottbauer, Wolfgang; Said, Samir M.; Braun‐Dullaeus, Ruediger C.; Banning, Adrian P.; Cuculi, Florim; Kobza, Richard; Fischer, Thomas; Vasankari, Tuija; Airaksinen, Juhani; Opolski, Grzegorz; Dworakowski, Rafał; MacCarthy, Philip; Kaiser, Christoph; Oßwald, Stefan; Galiuto, Leonarda; Crea, Filippo; Dichtl, Wolfgang; Empen, Klaus; Felix, Stephan B.; Delmas, Clément; Lairez, Olivier; El‐Battrawy, Ibrahim; Akın, İbrahim; Borggrefe, Martin; Horowitz, John D.; Kozel, Martin; Toušek, Petr; Widimský, Petr; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Winchester, David E.; Ukena, Christian; Bax, Jeroen J.; Prasad, Abhiram; Böhm, Michael; Lüscher, Thomas F.; Ruschitzka, Frank; Templin, Christian

doi:10.1016/j.jacc.2018.06.016

Cited by 237 publications

(181 citation statements)

References 19 publications

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“…Clinical symptoms and signs at presentation, along with electrocardiographic (ECG) and laboratory changes, may mimic acute coronary syndrome (ACS) or acute heart failure . Although TTS has long been considered a benign condition, recent studies reported that it can be associated with significant adverse events both during hospitalization and after discharge . Therefore, there is a compelling need for an optimal preventive therapy to reduce the incidence of adverse events following TTS.…”

Section: Introductionmentioning

confidence: 99%

Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry

D’Ascenzo

Gili

Bertaina

et al. 2019

European J of Heart Fail

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Aims The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30‐day and 5‐year follow‐up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30‐day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50–3.04, P = 0.64] or 5‐year follow‐up (HR 1.11, 95% CI 0.78–1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS‐based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30‐day and 5‐year follow‐up. These findings should be confirmed in adequately powered randomized controlled trials. http://clinicaltrials.gov Identifier: NCT01947621.

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Section: Introductionmentioning

confidence: 99%

Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry

D’Ascenzo

Gili

Bertaina

et al. 2019

European J of Heart Fail

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“…3 Secondary TS had a worse outcomes in the InterTAK registry. 12 Acute prognosis is also worse than initially believed, 13 with in-hospital rates of death and shock being similar to age-and sex-matched ACS patients. RV involvement occurs in 20%.…”

Section: Introductionmentioning

confidence: 93%

Takotsubo cardiomyopathy in a man with no trigger and multiple cardioembolic complications—A rare constellation

et al. 2019

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C ARDIAC MRI S e c tio n Edito r -Ro b e r t W.W. B ie d e rma n , M D a n d S e c tio n A sso ciate Edito r -G a rima A ro r a , M D Additional supporting information may be found online in the Supporting Information section at the end of the article.Movie S1. Initial echo (apical 4-chamber view) with LVEF 35%, hypokinesis of mid-and apical LV, preserved basal contractility and a large, mobile apical LV clot.Movie S2. Echo 1 wk later (apical 4-chamber view) with LVEF 65%-70%, and no thrombus.Movie S3. Cardiac MRI (4-chamber view) with LVEF 65%-70%, no thrombus, normal RV function, and a small pericardial effusion.How to cite this article: Kalra DK, Lichtenstein SJ, Bai C, et al.Takotsubo cardiomyopathy in a man with no trigger and multiple cardioembolic complications-A rare constellation.

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“…embargo, en el Perú se desconoce la carga de enfermedad por esta patología. A nivel internacional, existe un gran registro (InterTAK) que no incluye casos peruanos (4) , con lo cual esta patología permanece subdiagnosticada e infrareportada en el país, a pesar de su potencial impacto en la salud pública dada su elevada morbimortalidad y demanda de recursos especializados en los sistemas de salud (5) .…”

Section: Mensajes Claveunclassified

“…La mortalidad del síndrome de Takotsubo a largo plazo es similar al síndrome coronario agudo. Sin embargo, si agrupamos a los pacientes según la clasificación de InterTAK, los pacientes con estrés emocional (grupo I), tienen mejor pronóstico que los casos sin estrés asociado (grupo II) o los síndromes coronarios agudos; mientras que, los casos por estrés físico (grupo III) tienen mayor mortalidad que los grupos previos (5) . Lo antes mencionado, concuerda con los dos fallecidos (en el seguimiento) de este estudio, que fueron síndromes de Takotsubo asociados a un gatillo físico.…”

Section: Referencias Bibliográficasunclassified

Características clínicas y complicaciones del síndrome de Takotsubo en un centro de referencia de la seguridad social peruana

Espinoza-Alva¹,

Pampa-Quenta²,

Rodríguez-Olivares³

et al. 2019

Rev Peru Med Exp Salud Publica

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RESUMENCon el objetivo de describir las características clínicas y complicaciones del síndrome de Takotsubo, se realizó un estudio de serie de casos de pacientes que ingresaron con esta patología al Instituto Nacional Cardiovascular-INCOR en Lima-Perú, entre enero de 2013 a diciembre de 2018. Se incluyeron 26 pacientes, con una edad promedio de 69 años y predominio del sexo femenino (96,2%), además un desencadenante se identificó en 23 casos (88,5%). En el electrocardiograma, el 61,5% tuvo supradesnivel del segmento ST; y en la evolución el 92,3% mostró ondas T negativas y el 38,5% un intervalo QTc >500 ms. Las complicaciones intrahospitalarias fueron choque cardiogénico (11,5%), fibrilación auricular (7,7%) y taquicardia ventricular (7,7%). En esta serie, el síndrome de Takotsubo predominó en mujeres posmenopáusicas, generalmente desencadenado por un factor estresante, con una baja tasa de complicaciones y ausencia de mortalidad intrahospitalaria.Palabras clave: Cardiomiopatía de Takotsubo; Complicaciones; Perú (fuente: DeCS BIREME). ABSTRACTIn order to describe the clinical features and complications of Takotsubo syndrome, a case series study was conducted with patients admitted with this pathology to the National Cardiovascular Institute-INCOR in Lima-Peru between January 2013 and December 2018. Twenty-six patients (26) were included, with an average age of 69 years and female predominance (96.2%); additionally, a trigger was identified in 23 cases (88.5%). In the electrocardiogram, 61.5% had ST segment elevation; and, in the evolution, 92.3% showed negative T waves and 38.5% a QTc interval >500 ms. In-hospital complications were cardiogenic shock (11.5%), atrial fibrillation (7.7%) and ventricular tachycardia (7.7%). In this series, Takotsubo syndrome predominated in postmenopausal women, usually triggered by a stressor, with a low complication rate and no in-hospital mortality.

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Long-Term Prognosis of Patients With Takotsubo Syndrome

Cited by 237 publications

References 19 publications

Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry

Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry

Takotsubo cardiomyopathy in a man with no trigger and multiple cardioembolic complications—A rare constellation

Características clínicas y complicaciones del síndrome de Takotsubo en un centro de referencia de la seguridad social peruana

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