Long-term prognosis of patients with anginalike chest pain and normal coronary angiographic findings

Lichtlen, Paul R.; Bargheer, Klaus; Wenzlaff, Paul

doi:10.1016/0735-1097(94)00519-v

Cited by 159 publications

(97 citation statements)

References 33 publications

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“…Most studies investigating the relationship between NCCP and cardiac morbidity and mortality, are conducted with NCCP patients with negative coronary angiography. These studies have reported an excellent mortality prognosis with survival rates of 91-98% up to 12 years after the angiographic assessments (17)(18)(19). In contrast, two population-based studies reported that the mortality rate of chest pain patients is higher than that of the normal population.…”

Section: Prognosis Of Chest Pain Patientsmentioning

confidence: 87%

A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

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Section: Prognosis Of Chest Pain Patientsmentioning

confidence: 87%

A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

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“…Studies supporting good cardiovascular outcome included young adults who had less cardiac risk factors. 56 Lichtlen et al 60 reported that NCCP patients experiencing a coronary event had significantly more risk factors like hypercholesterolemia, hypertension, smoking, and diabetes mellitus than those without a coronary event. One possible conclusion could be that age ≥55 years with increased cardiac risk factors could confer a long-term cardiovascular risk compared with NCCP patients between 45 and 50 years of age with less risk factors.…”

Section: Resultsmentioning

confidence: 99%

Noncardiac chest pain: systematic review of the literature on prognosis

Meresh¹,

Piletz²,

Halaris³

2018

RRCC

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Background: Noncardiac chest pain (NCCP) is defined as persistent angina-like chest pain with no evidence of cardiac disease. There is some controversy about the long-term morbidity and mortality outcomes of NCCP patients. Many studies have found no significant differences in death rates in chest pain patients without coronary artery disease compared to the general population. However, studies that include longer follow-up periods and a better characterization of the NCCP population reveal a twofold elevation in the relative risk of adverse cardiac events over 5-26 years. This review sought to identify studies in relation to cardiovascular and psychological prognosis of NCCP patients. Methods: PubMed database and reference lists from relevant publications were reviewed. Inclusion criteria were systematic reviews, prospective studies, and retrospective surveys from 1970 to 2011. Search terms were as follows: chest pain, noncardiac chest pain, nonspecific chest pain, unexplained chest pain, prognosis of noncardiac chest pain, prognosis of angina with normal angiography, and angina with normal coronary arteries. Results: Studies supporting worse outcome (cardiac morbidity and mortality; n=16) included 173,875 patients with mean age 57 and mean length of follow-up 7.5 years. Studies supporting good outcome (n=25) included 244,998 patients with age 50 and length of follow-up 5 years. Articles supporting poor psychological outcome (n=9) included 3,987 patients and length of follow-up 2 years. Conclusion: There are mixed data on long-term morbidity, cardiovascular adverse events, and mortality of NCCP patients. Some studies provide supporting evidence for poor outcome, while others provide evidence for positive outcome. However, many patients with NCCP have prolonged psychosocial comorbidity. The heterogeneity of NCCP and study populations limited definitive conclusions. However, many patients with NCCP have psychiatric morbidity and poor quality of life. Several questions remain about NCPP with respect to the psychopathology and pathophysiology of this condition. Whether NCCP patients have good or bad outcome requires careful risk stratification.

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“…With regard to the prognosis of syndrome X and microvascular angina, there have been some reports showing favorable prognoses in patients with angina-like chest pain and normal coronary arteriograms; [11][12][13][14][15][16][17][18][19][20] However, progressive reduction in left ventricular function has also been described in other reports from Western countries, 9,10 but to date there have been few reports on the prognosis of syndrome X in Japanese patients. 20 This study describes the clinical features and long-term prognosis of patients with microvascular angina, diagnosed by our strict criteria, who underwent cardiac catheterization and endomyocardial biopsy from 1988 to 1997 at Showa University Hospital.…”

mentioning

confidence: 99%