Long‐term prognosis of medullary thyroid carcinoma

Rendl, Gundula; Manzl, M.; Hitzl, Wolfgang; Sungler, P.; Pirich, Christian

doi:10.1111/j.1365-2265.2008.03229.x

Cited by 80 publications

(80 citation statements)

References 30 publications

(106 reference statements)

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“…In 3 patients with a DOPA-positive loco-regional relapse a re-operation with curative intent was offered. SUV max values were higher for 18 F-FDG compared to 18 F-DOPA (mean 12.7 +/-4.1 vs. 5.5 +/-2.1, p<0.05). Calcitonin was higher in PET positive patients compared to PET negative ones, while no significant differences were observed between 18 F-DOPA and 18 F-FDG positive patients.…”

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confidence: 80%

“…showed more lesions on 18 F-FDG, 1 was positive at 18 F-FDG alone and 5 at 18 F-DOPA alone. In 3 patients with a DOPA-positive loco-regional relapse a re-operation with curative intent was offered.…”

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confidence: 99%

“…Results: Foci of abnormal uptake were observed in 15 patients at 18 F-DOPA and in 11 at 18 F-FDG; 8 patients showed the same number of positive lesions with both tracers, 2…”

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confidence: 99%

“…CI had revealed metastatic deposits in 9 patients. Patients were referred to us for a PET/CT with 18 F-DOPA and 18 F-FDG. Histologic/cytologic confirmation of recurrent MTC was obtained in at least one PET-positive lesion in all patients.…”

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confidence: 99%

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Dual PET/CT with 18F-DOPA and 18F-FDG in metastatic medullary thyroid carcinoma and rapidly increasing calcitonin levels: Comparison with conventional imaging

Marzola¹,

Pelizzo²,

Ferdeghini³

et al. 2010

European Journal of Surgical Oncology (EJSO)

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confidence: 80%

mentioning

confidence: 99%

“…Results: Foci of abnormal uptake were observed in 15 patients at 18 F-DOPA and in 11 at 18 F-FDG; 8 patients showed the same number of positive lesions with both tracers, 2…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Dual PET/CT with 18F-DOPA and 18F-FDG in metastatic medullary thyroid carcinoma and rapidly increasing calcitonin levels: Comparison with conventional imaging

Marzola¹,

Pelizzo²,

Ferdeghini³

et al. 2010

European Journal of Surgical Oncology (EJSO)

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“…GrozinskyGlasberg et al [3] Gülben et al [13] Clark et al [14] Rendl et al [15] Hyer et al [16] Dottorini et al [17] Kebebew et al [18] Ito et al [19] Study period 1992-2012 1970-2006 1993-2003 1969-2000 1996-2008 1949-1998 1970-1992 1960-1998 1975 According to our knowledge, this is the first study that has analyzed the outcome of the patients with this type of thyroid cancer followed up in a single endocrine care center in Romania. In addition, the majority of the patients underwent surgery in a single clinic from the same hospital.…”

Section: Discussionmentioning

confidence: 99%

Results of Surgical Therapy in Patients with Medullary Thyroid Carcinoma

et al. 2015

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Medullary thyroid carcinoma (MTC) is a rare form of malignancy, having an intermediate prognosis. Controversies exist regarding the best surgical approach. The aim of the study was to analyze the outcome in a group of patients with MTC, diagnosed and followed up in a single care center. We performed a retrospective analysis of all the patients diagnosed with MTC in the Department of Endocrinology from the County Emergency Hospital Timisoara between 1992 and 2012. The study group included 19 patients, 6 men (31.6 %), mean age 41.2±12.5 years (20-72 years). The preoperative diagnosis was based on the protocol for nodular thyroid disease. Total or near-total thyroidectomy was performed in 10 out of 16 patients who could be operated. Postoperative follow-up included repeated measurements of serum calcitonin and imaging investigations. Nine out of the total of 19 (47.3 %) patients had hereditary forms of MTC. Most of the cases (84.2 %) were submitted to surgery. The median duration of follow-up was 84 months. The pTNM staging indicated that the majority of the patients with hereditary MTC were diagnosed in an earlier stage. Disease remission was achieved in 7 cases (43.8 %). Four patients, all with sporadic forms, died. Survival rates at 1, 5 and 10 years were significantly higher (p=0.048) in patients with hereditary MTC. An early diagnosis of MTC allows a better surgical approach and an improved survival rate. We support the general recommendation that modified radical neck dissection is not necessary for all the patients with MTC.

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Medical management of metastatic medullary thyroid cancer

Maxwell

Sherman

O'Dorisio

et al. 2014

Cancer

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Medullary thyroid cancer (MTC) is an aggressive form of thyroid cancer, which occurs in both heritable and sporadic forms. Discovery that mutations in the RET protooncogene predispose to familial cases of this disease has allowed for presymptomatic identification of gene carriers and prophylactic surgery to improve the prognosis of these patients. A significant number of patients with the sporadic type of MTC and even with familial disease, still present with nodal or distant metastases, making surgical cure difficult. Over the past several decades, many different types of therapy for metastatic disease have been attempted, with limited success. Improved understanding of the molecular defects and pathways involved in both familial and sporadic MTC has resulted in new hope for these patients with the development of drugs targeting the specific alterations responsible. This new era of targeted therapy with kinase inhibitors represents a significant step forward from previous trials of chemotherapy, radiotherapy, and hormonal therapy. Although much progress has been made, additional agents and strategies are needed to achieve durable, long-term responses in patients with metastatic MTC. This article reviews the history and results of medical management for metastatic MTC from the early 1970s up until the present day.

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Long‐term prognosis of medullary thyroid carcinoma

Cited by 80 publications

References 30 publications

Dual PET/CT with 18F-DOPA and 18F-FDG in metastatic medullary thyroid carcinoma and rapidly increasing calcitonin levels: Comparison with conventional imaging

Dual PET/CT with 18F-DOPA and 18F-FDG in metastatic medullary thyroid carcinoma and rapidly increasing calcitonin levels: Comparison with conventional imaging

Results of Surgical Therapy in Patients with Medullary Thyroid Carcinoma

Medical management of metastatic medullary thyroid cancer

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