Long‐term prognosis in patients with Takotsubo syndrome

Akashi, Yoshihiro J.

doi:10.1002/ejhf.1417

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…In men with TTS, the prognosis is often poor, due to the prevalence of conditions with elevated levels of circulating catecholamines. An LV ejection fraction value under 35% is an independent predictor of short-term and long-term mortality in patients with TTS [29,53].…”

Section: Treatment and Prognosis Of Takotsubo Syndromementioning

confidence: 99%

The relevance of Takotsubo cardiomyopathy as a stress-induced disease

Ganych¹,

Oflidi²,

Zaitseva³

et al. 2023

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Takotsubo cardiomyopathy, or Takotsubo syndrome, can be quite rare found, but however the frequency of diagnosing with this disease among patients of cardiology departments is constantly growing. On the one hand, this may be due to improved diagnostics of this pathology, and on the other hand, to an increasing frequency of mental disorders in the human population and the spread of other risk factors, including drug-induced variants. The pathogenesis of the development of Takotsubo cardiomyopathy is associated with an increase in the level of catecholamines, which may be the result of a reactive sympathetic enhancement in response to external factors or be the result of taking antidepressants that can produce a similar effect. Although the diagnostics of this pathology has made significant progress, but however there is still no consensus on the strategy of treatment. This is due to the lack of large-scale randomized prospective studies that could justify one or another therapeutic approach. Basically, the efforts of medical doctors are aimed at maintaining cardiac activity, eliminating the trigger of the disease and at treating complications. The purpose of this review was to summarize the accumulated information related to the problems of etiology, pathogenesis, diagnosis and treatment of Takotsubo cardiomyopathy with an emphasis on the variants associated with the use of antidepressants.

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Section: Treatment and Prognosis Of Takotsubo Syndromementioning

confidence: 99%

The relevance of Takotsubo cardiomyopathy as a stress-induced disease

Ganych¹,

Oflidi²,

Zaitseva³

et al. 2023

View full text Add to dashboard Cite

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“…Since it is usually transient and resolves with time, the prognosis is generally favorable. However, numerous complications may arise during acute presentation [ 10 , 11 ]. Approximately 20% of patients experienced serious adverse events during hospitalization, which is comparable to patients with acute coronary syndrome [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Takotsubo Cardiomyopathy: Patients Characteristics, Mortality, and Clinical Significance of Left Ventricular Outflow Tract Gradient, Retrospective Study

Daralammouri,

Hamayel,

Abugaber

et al. 2024

Cardiology Research and Practice

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Background. Takotsubo cardiomyopathy (TC) is a reversible left ventricular systolic dysfunction with apical ballooning. Left ventricular outflow tract (LVOT) obstruction may develop in these cases due to hyperdynamic state of the left ventricle. Limited data are available on the prevalence of LVOT gradient in TC and its association with patient outcomes and mortality. Methods. Data were collected retrospectively for patients diagnosed with TC in a single tertiary center, demographic information, blood analysis results, and imaging finding including ejection fraction, and LVOT gradient was obtained from medical records. Additionally, medical treatment and outcome during hospitalization were extracted. Follow‐up was conducted through cardiology clinic or phone contact. Result. A total of 59 patients diagnosed with TC were reviewed during hospitalization, and 40 patients were followed up after discharge by phone contact and cardiology clinic. Most patients were female (91.5%), and nonsignificant coronary artery disease was present in 16.9% of patients. Approximately two‐third of the patients had a reduced ejection fraction on admission, and only two patients (5.4%) continued to have reduced ejection fraction on echocardiography follow‐up within a period of 2–14 days. LVOT gradient was present in 17 patients (28.5%); patients with preserved ejection fraction had a higher probability of having an LVOT gradient. However, there was no association between LVOT gradient and shock or mortality. Four patients (6.7%) experienced 30‐day mortality, while all‐cause mortality was reported in eight patients (13.5%) over the follow‐up period (mean (±SD) 20.8 months ± 16.2). Conclusion. LVOT obstruction may occur in TC patients; it has no correlation with shock or mortality. However, determining whether there is a gradient is important for deciding on specific treatment approach.

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