Long-term prognosis for patients with chronic leg ulcers: a prospective cohort study

Nelzén, Olle; Bergqvist, David; Lindhagen, A

doi:10.1016/s1078-5884(97)80179-7

Cited by 112 publications

(91 citation statements)

References 25 publications

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“…3 Nelzen and colleagues in Sweden followed 382 patients who had open leg and/or foot ulcers in 1988 (206 with predominantly venous aetiology) for 5 years to determine healing and recurrence outcomes. 11 At follow-up, 58% of all patients had healed ulcers, 38% had open ulcers and 4% had undergone amputation. Looking at patients with ulceration due to venous incompetence (n = 135 at 54 months), only 44% had healed their original ulcer without subsequent recurrence compared with 59% of patients with arterial ulcers and 59% of people with diabetes.…”

Section: Long-term Outcomesmentioning

confidence: 96%

VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers

Iglesias¹,

Nelson²,

Cullum

et al. 2004

Health Technol Assess

116

105

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Section: Long-term Outcomesmentioning

confidence: 96%

VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers

Iglesias¹,

Nelson²,

Cullum

et al. 2004

Health Technol Assess

116

105

View full text Add to dashboard Cite

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“…Previous studies have assessed the effects of foot ulceration and osteomyelitis on morbidity and mortality in diabetic patients (28)(29)(30)(31); such studies suggest that patients with foot ulcers have reduced quality of life and increased morbidity and mortality when compared with patients without foot ulcers. Another study has shown that diabetic patients with foot ulcers have a lower survival rate when compared with nondiabetic patients with foot ulcers (32). The increased mortality associated with diabetic foot ulcers seems to result from the additional comorbidity-an interesting finding that requires further investigation.…”

Section: Oyibo and Associatesmentioning

confidence: 99%

A Comparison of Two Diabetic Foot Ulcer Classification Systems

et al. 2001

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A Comparison of Two Diabetic Foot Ulcer Classification SystemsThe Wagner and the University of Texas wound classification systemsOBJECTIVE -In this study, the following two ulcer classification systems were applied to new foot ulcers to compare them as predictors of outcome: the Wagner (grade) and the University of Texas (UT) (grade and stage) wound classification systems.RESEARCH DESIGN AND METHODS -Ulcer size, appearance, clinical evidence of infection, ischemia, and neuropathy at presentation were recorded, and patients were followed up until healing or for 6 months.RESULTS -Of 194 patients with new foot ulcers, 67.0% were neuropathic, 26.3% were neuroischemic, 1.0% were ischemic, and 5.7% had no identified underlying factors. Median (interquartile range [IQR]) ulcer size at presentation was 1.5 cm 2 (0.6-4.0). Lower-limb amputations were performed for 15% of ulcers, whereas 65% healed [median (IQR) healing time 5 (3-10) weeks] and 16% were not healed at study termination; 4% of patients died. Wagner grade (P Ͻ 0.0001), and UT grade (P Ͻ 0.0001) and stage (P Ͻ 0.001) showed positive trends with increased number of amputations. For UT stage, the risk of amputation increased with infection both alone (odds ratio [OR] = 11.1, P Ͻ 0.0001) and in combination with ischemia (OR = 14.7, P Ͻ 0.0001), but not significantly with ischemia alone (OR = 4.6, P = 0.09). Healing times were not significantly different for each grade of the Wagner (P = 0.1) or the UT system (P = 0.07), but there was a significant stepwise increase in healing time with each stage of the UT system (P Ͻ 0.05), and stage predicted healing (P Ͻ 0.05).CONCLUSIONS -Increasing stage, regardless of grade, is associated with increased risk of amputation and prolonged ulcer healing time. The UT system' s inclusion of stage makes it a better predictor of outcome.

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“…1,2 The majority of care for these patients is delivered in the community, at a clinic location or at home, principally by teams of District Nurses (DN). 3 Evidence demonstrates that high compression, multilayer bandaging represents the 'gold standard' approach to the management of CVLU which, when correctly applied, improves healing times when compared to the absence of compression. 4,5 However, research suggests that much of the care for this patient group has an exclusive wound management focus which is of varying quality and little attention is paid to the impact that the ulceration poses on the individual.…”

Section: Introductionmentioning

confidence: 99%

The impact of chronic venous leg ulcers: a systematic review

et al. 2014

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Long-term prognosis for patients with chronic leg ulcers: a prospective cohort study

Abstract: Only patients with non-venous ulcers have a higher mortality than expected. The long-term healing prognosis for leg ulcer patients is poor and worst for patients with venous ulcers.

Cited by 112 publications

References 25 publications

VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers

VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers

A Comparison of Two Diabetic Foot Ulcer Classification Systems

The impact of chronic venous leg ulcers: a systematic review

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