Long-term prevention of allergic diseases by using protein hydrolysate formula in at-risk infants

Mallet, E.; Henocq, A

doi:10.1016/s0022-3476(05)81415-5

Cited by 106 publications

(66 citation statements)

References 18 publications

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“…However, using the criteria of a 2006 Cochrane review, 41 only 14 randomized or quasirandomized (eg, using alternation) trials in term infants compared the use of partially or extensively hydrolyzed formula with the use of human milk or an adapted cow milk formula. [42][43][44][45][46][47][48][49][50][51][52][53][54][55] All of these trials have followed up with at least 80% of study participants. It is important to note that none of these studies reported any adverse effects, including any adverse effect on infant growth.…”

Section: Role Of Hydrolyzed Formula On the Development Of Atopic Diseasementioning

confidence: 99%

Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas

Greer¹,

Sicherer²,

Burks³

2008

Pediatrics

984

708

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Section: Role Of Hydrolyzed Formula On the Development Of Atopic Diseasementioning

confidence: 99%

Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas

Greer¹,

Sicherer²,

Burks³

2008

Pediatrics

984

708

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“…Because the partially hydrolyzed formula is cheaper and more palatable than the extensively hydrolyzed formula, it was introduced for feeding high-risk infants who cannot tolerate the extensively hydrolyzed formula to prevent the development of atopic disease. The preventive effect of the partially hydrolyzed formula is still controversial because it contains a significant number of peptides with relatively high molecular weight compared with the extensively hydrolyzed formula (2)(3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Short-term Effect of Partially Hydrolyzed Formula on the Prevention of Development of Atopic Dermatitis in Infants at High Risk

et al. 2003

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This short-term, prospective study was aimed to assess the effects of partially hydrolyzed formula (PHF) on the prevention of the development of atopic dermatitis in infants at high risk. The infants of parents with allergy symptoms and serum total IgE over 200 kU/L were divided into 3 groups by their feeding patterns: PHF group (n=15), standard formula (SF) group (n=32), and breast milk (BM) group (n=22). No allergenic food was given during the study period of 6 months, and breastfeeding mothers avoided egg ingestion. Their atopic symptoms were monitored every 2 months. The cumulative incidence and prevalence of atopic dermatitis at the age of 6 months were significantly less in the PHF group than in the SF group (47% vs. 78%, p<0.05; 20% vs. 59%, p<0.05). Those rates of the PHF group were also less than those of the BM group, but they were not statistically significant. There was no difference in the onset age and disease severity. These results suggest that early feeding of PHF to infants at high risk has a short-term preventive effect on the development of atopic dermatitis during the first 6 months of life. Long-term preventive effects should be evaluated.

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“…In total, 10 high-quality studies (enrolling 3473 patients) were included, of which 1124 had a multifaceted intervention design [23][24][25] and 2349 had a mono-intervention design. 21,[26][27][28][29][30][31] Several studies had repeated measurements on different ages of the children. The results suggested that a multifaceted approach might be effective in delaying or preventing asthma, whereas a mono-intervention does not seem to have such a protective effect.…”

Section: C) the Interaction Between Genotype And Environment -Childhomentioning

confidence: 99%

Global strategies for reducing the burden from asthma

Schayck

2013

Primary Care Respiratory Journal

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Asthma is one of the most important chronic diseases in childhood. For several decades, a steady increase in prevalence has been observed worldwide. In the structural collaboration between the Centre for Population Health Services in Edinburgh and the Research Institute CAPHRI of Maastricht we investigated the possibilities for primary prevention of asthma in childhood. We found that a multifaceted approach might be effective in delaying or preventing asthma, whereas a mono-intervention does not seem to have such a protective effect. The most likely explanation is that the development of a multifactorial disease, such as asthma, is extremely difficult, if not impossible, to prevent by eliminating only one risk factor.Underdiagnosis of asthma is still a big problem in primary care. Most patients do not present bronchial symptoms to the general practitioner, even though they have decreased lung function, so they remain unknown and undiagnosed. However, patients who do present with respiratory problems and who have reduced lung function are not always recognised as such. We found that the perception of dyspnoea seems to determine, at least in part, the presentation to the general practitioner with symptoms.These observations show that both the prevention of the development of asthma in early childhood, as well as case finding of asthma in adulthood, do not seem to be very effective in primary care. More research is needed to clarify what steps can be taken to reduce the global burden from asthma.

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Long-term prevention of allergic diseases by using protein hydrolysate formula in at-risk infants

Cited by 106 publications

References 18 publications

Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas

Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas

Short-term Effect of Partially Hydrolyzed Formula on the Prevention of Development of Atopic Dermatitis in Infants at High Risk

Global strategies for reducing the burden from asthma

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