Long‐term potentiation in the avian hippocampus does not require activation of the N‐methyl‐D‐aspartate (NMDA) receptor

Wieraszko, Andrzej; Ball, Gregory F.

doi:10.1002/syn.890130208

Cited by 31 publications

(19 citation statements)

References 42 publications

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“…Therefore, the presence of AMPA and NMDA receptors in the quail hippocampus is consistent with the idea that LTP also takes place in avian hippocampus, as already indicated by electrophysiologic studies of pigeons and songbirds (Wieraszko and Ball, 1993;Shapiro and Wieraszko, 1996).…”

Section: Functional Implicationssupporting

confidence: 78%

Immunocytochemical localization of ionotropic glutamate receptors subunits in the adult quail forebrain

et al. 2000

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The excitatory amino acid glutamate is implicated in the central control of many neuroendocrine and behavioral processes. The ionotropic glutamate receptors are usually divided into the N-methyl-D-aspartate (NMDA) and non-NMDA (kainate and AMPA) subtypes. Subunits of these receptors have been cloned in a few mammalian species. Information available in birds is more limited. In quail, we recently demonstrated that glutamate agonists (kainate, AMPA, and NMDA) rapidly (within minutes) and reversibly decrease in vitro aromatase activity like several other manipulations affecting intracellular HCa(2+) pools. Aromatase catalyzes the conversion of androgens into estrogens which is a limiting step in the control by testosterone of many behavioral and physiologic processes. Therefore, glutamate could control estrogen production in the brain, but the anatomic substrate supporting this effect is poorly understood. In quail, aromatase is mainly localized in the preoptic-hypothalamic-limbic system. We visualized here the distribution of the major ionotropic glutamate receptors in quail by immunocytochemical methods by using commercial primary antibodies raised against rat glutamate receptor 1 and receptors 2-3 (GluR1, GluR2/3: AMPA subtype, Chemicon, CA), rat glutamate receptors 5-7 (GluR5-7: kainate subtype, Pharmingen, CA), and rat NMDA receptors (NMDAR1, Pharmingen, CA). Dense and specific signals were obtained with all antibodies. The four types of receptors are broadly distributed in the brain, and, in particular, immunoreactive cells are identified within the major aromatase cell groups located in the medial preoptic nucleus, ventromedial hypothalamus, nucleus striae terminalis, and nucleus taeniae. Dense specific populations of glutamate receptor-immunoreactive cells are also present with a receptor subtype-specific distribution in broad areas of the telencephalon. The distribution of glutamate receptors, therefore, is consistent with the idea that these receptors could be located at the surface of aromatase-containing cells and mediate the rapid regulation of aromatase activity in a direct manner.

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Section: Functional Implicationssupporting

confidence: 78%

Immunocytochemical localization of ionotropic glutamate receptors subunits in the adult quail forebrain

et al. 2000

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“…Compared with synaptic plasticity at glutamatergic synapses in other regions of the avian brain, LTP in area X shows similar NMDA receptor dependence to the LTP observed at the LMAN collaterals (Boettiger and Doupe, 2001) but not the LTP in the chick hippocampus (Wieraszko and Ball, 1993;Margrie et al, 1998). Interestingly, the NMDA receptor dependence is also shared by LTP induction at the mammalian corticostriatal synapses (Calabresi et al, 1992;Pennartz et al, 1993;Kombian and Malenka, 1994), further supporting the similarities between the avian and mammalian basal ganglia (Lewis et al, 1981;Vates and Nottebohm, 1995;Bottjer and Johnson, 1997;Reiner et al, 1998;Luo et al, 2001;Farries, 2002;Farries and Perkel, 2002).…”

Section: Comparison To Avian Ltp and Mammalian Corticostriatal Ltpmentioning

confidence: 60%

Long-Term Potentiation in an Avian Basal Ganglia Nucleus Essential for Vocal Learning

Ding¹,

Perkel²

2004

J. Neurosci.

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Vocal learning in songbirds provides an excellent model for sensorimotor learning in vertebrates, with an accessible, well-defined behavior and discrete neural substrate. The rich behavioral plasticity exhibited by songbirds, however, contrasts starkly with the scarcity of candidate cellular mechanisms. Here, we report for the first time on an activity-dependent form of synaptic plasticity in area X, a component of the song system required for song learning and song maintenance. In slice preparations of zebra finch area X, pairing of high-frequency presynaptic stimulation with postsynaptic depolarization induces Hebbian long-term potentiation (LTP) of the glutamatergic inputs to spiny neurons. This form of LTP requires activation of NMDA receptors and D1-like dopamine receptors. In addition, LTP is observed in birds as young as 47 d after hatching and also in adult birds but not in younger birds, providing evidence of developmental regulation of the onset of synaptic plasticity. These properties make this form of LTP the best known candidate mechanism for reinforcement-based vocal learning in juveniles and song maintenance in adult birds.

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“…1, 2, 6). This intrinsic fibre system may form the morphological basis for the long term potentiation reported to occur in the homing pigeon (Wieraszko and Ball 1993;Shapiro and Wieraszko 1996;Casini et al 1997;Margrie et al 1998).…”

Section: Discussionmentioning

confidence: 99%

A comparative Golgi study of chicken (Gallus domesticus) and homing pigeon (Columba livia) hippocampus

et al. 2000

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Neurons and fibres in the chick and homing pigeon hippocampus were described following Golgi impregnation. Two principal classes of neurons were distinguished: projection neurons with distant projecting axons and spiny dendrites, and local circuit neurons. In the homing pigeon and chicken hippocampus there are three types of projection neurons: pyramidal, pyramidal-like and multipolar. The pyramidal and pyramidal-like neurons are only found in the central 'pyramidal' layer of the hippocampus whereas multipolar neurons are present in the suprapyramidal, pyramidal and infrapyramidal layers. The axon of projection neurons typically emits several varicose collaterals from the initial section. Most of these collaterals extend along the infrapyramidal layer of the hippocampus, while others ascend to the pyramidal and suprapyramidal layers where they branch. The number of impregnated axon collaterals was higher in the homing pigeon than in the chick hippocampus. A variety of multi-angular/ovoid local circuit neurons ranging from small to large size are found in the homing pigeon and chick hippocampus. Their axons develop local arborization of varicose branches, the extent of which varies with the type of local circuit neurons. The density of GABA immunopositive local circuit neurons was found to be greater in the homing pigeon than in the chick. The profuse arborization of projection neuron axon collaterals and the higher density of GABA-immunopositive local circuit neurons in the homing pigeon hippocampus may underlie the differences in hippocampal function between the homing pigeon and chick, and this complex local connectivity may contribute to the ability of spatial orientation and memory.

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Long‐term potentiation in the avian hippocampus does not require activation of the N‐methyl‐D‐aspartate (NMDA) receptor

Cited by 31 publications

References 42 publications

Immunocytochemical localization of ionotropic glutamate receptors subunits in the adult quail forebrain

Immunocytochemical localization of ionotropic glutamate receptors subunits in the adult quail forebrain

Long-Term Potentiation in an Avian Basal Ganglia Nucleus Essential for Vocal Learning

A comparative Golgi study of chicken (Gallus domesticus) and homing pigeon (Columba livia) hippocampus

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