Long-term postoperative control of eosinophilic chronic rhinosinusitis recurrence by inserting a steroid-eluting, sinus-bioabsorbable device reduces the dosage of oral steroid

Konno, Wataru; Kashiwagi, Takashi; Tsunemi, Yuichiro; Goto, Kazutaka; Haruna, Shinichi

doi:10.1016/j.anl.2018.09.001

Cited by 13 publications

(2 citation statements)

References 17 publications

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“…Sinonasal topical steroid treatment Sinonasal topical steroid treatment using a bioabsorbable device consisting of oxidised regenerated cellulose (Surgicel Absorbable Haemostat; Johnson and Johnson, Tokyo, Japan) and triamcinolone acetonide (Kenacort, 40 mg/ml vial; Bristol Myers Squibb, Tokyo, Japan) was used, based on previous reports. 16,17 First, cotton swabs impregnated with 4 per cent xylocaine and 5000-fold diluted adrenaline were bilaterally inserted into the surgically opened ethmoid sinuses and olfactory clefts, to shrink the nasal mucosae, for 5-10 minutes. Second, a moderate amount of oxidised regenerated cellulose was inserted bilaterally into the ethmoid sinuses and olfactory clefts.…”

Section: Additional Steroid Treatmentmentioning

confidence: 99%

Usefulness of post-operative endoscopic score for optimal treatment selection in recurrent eosinophilic chronic rhinosinusitis

et al. 2023

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Objective This study retrospectively analysed post-operative endoscopic scores to determine the optimal post-operative treatment in patients with eosinophilic chronic rhinosinusitis undergoing functional endoscopic sinus surgery. Methods In total, 339 adults who underwent initial bilateral functional endoscopic sinus surgery for eosinophilic chronic rhinosinusitis were enrolled. Patients were divided into group A, which required no additional post-operative treatment; group B, which required local/systemic steroids post-operatively; and group C, which further required dupilumab and/or revision surgery. Results Sixty-five per cent of patients could be treated with initial functional endoscopic sinus surgery (group A). Post-operative steroids were required in 35 per cent of patients with a post-operative endoscopic score of 30 per cent (group B). Further advanced treatments with dupilumab and/or revision functional endoscopic sinus surgery were required in 10 per cent of patients with a post-operative endoscopic score of 65 per cent (group C). Conclusion The post functional endoscopic sinus surgery endoscopic score can be used as an index to determine treatment at the time of eosinophilic chronic rhinosinusitis recurrence.

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Section: Additional Steroid Treatmentmentioning

confidence: 99%

Usefulness of post-operative endoscopic score for optimal treatment selection in recurrent eosinophilic chronic rhinosinusitis

et al. 2023

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“… 3 9 Another feature of eCRSwNP is the efficacy of glucocorticoid therapy. 12 Therefore, glucocorticoid therapy would be helpful to identify these kinds of patients in an early phase, in order to guide overall long-term management. Tissue analysis remains the gold standard for the classification of eCRSwNP and non-eCRSwNP.…”

Section: Introductionmentioning

confidence: 99%

Development, Validation and Comparison of Artificial Neural Network and Logistic Regression Models Predicting Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Zhou

Fan

Qin

et al. 2023

Allergy Asthma Immunol Res

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Purpose Chronic rhinosinusitis with nasal polyps (CRSwNP) can be classified into eosinophilic CRSwNP (eCRSwNP) and non-eosinophilic CRSwNP (non-eCRSwNP) by tissue biopsy, which is difficult to perform preoperatively. Clinical biomarkers have predictive value for the classification of CRSwNP. We aimed to evaluate the application of artificial neural network (ANN) modeling in distinguishing different endotypes of CRSwNP based on clinical biomarkers. Methods Clinical parameters were collected from 109 CRSwNP patients, and their predictive ability was analyzed. ANN and logistic regression (LR) models were developed in the training group (72 patients) and further tested in the test group (37 patients). The output variable was the diagnosis of eCRSwNP, defined as tissue eosinophil count > 10 per high-power field. The receiver operating characteristics curve was used to assess model performance. Results A total of 15 clinical features from 60 healthy controls, 60 eCRSwNP and 49 non-eCRSwNP were selected as candidate predictors. Nasal nitric oxide levels, peripheral eosinophil absolute count, total immunoglobulin E, and ratio of bilateral computed tomography scores for the ethmoid sinus and maxillary sinus were identified as important features for modeling. Two ANN models based on 4 and 15 clinical features were developed to predict eCRSwNP, which showed better performance, with the area under the receiver operator characteristics significantly higher than those from the respective LR models (0.976 vs. 0.902, P = 0.048; 0.970 vs. 0.845, P = 0.011). All ANN models had better fits than single variable prediction models (all P < 0.05), and ANN model 1 had the best predictive performance among all models. Conclusions Machine learning models assist clinicians in predicting endotypes of nasal polyps before invasive detection. The ANN model has the potential to predict eCRSwNP with high sensitivity and specificity, and is superior to the LR model. ANNs are valuable for optimizing personalized patient management.

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Sun

Shi

2022

Chronic Rhinosinusitis

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Long-term postoperative control of eosinophilic chronic rhinosinusitis recurrence by inserting a steroid-eluting, sinus-bioabsorbable device reduces the dosage of oral steroid

Cited by 13 publications

References 17 publications

Usefulness of post-operative endoscopic score for optimal treatment selection in recurrent eosinophilic chronic rhinosinusitis

Usefulness of post-operative endoscopic score for optimal treatment selection in recurrent eosinophilic chronic rhinosinusitis

Development, Validation and Comparison of Artificial Neural Network and Logistic Regression Models Predicting Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

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