Long-term Postoperative Azithromycin in Patients with Chronic Rhinosinusitis: A Randomized Clinical Trial

Amali, Amin; Saedi, Babak; Rahavi-Ezabadi, Sara; Ghazavi, Hossein; Hassanpoor, Narges

doi:10.2500/ajra.2015.29.4244

Cited by 47 publications

(101 citation statements)

References 23 publications

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“…Regarding the mean scores of SNOT-22 questionnaire domains comparison between males and females patients' postoperative results. In our study, there was no significant difference in improvement in the questionnaire score between males and females, the result of our study was in agreement with a randomized controlled trial study in Iran by Amalia et al and a prospective cohort study in the United States by Adappa et al [8,9] . Also, another retrospective cohort study in the United States by Lal et al and a prospective study in Brazil by Bezerra et al [10,11] showed agreement with our results in this comparison.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of quality of life after Functional Endoscopic Sinus Surgery (FESS) in chronic rhinosinusitis patients in Menoufia Governorate

Behiry

El-Shazly

Abdelshafy

et al. 2019

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Background: Chronic rhinosinusitis has a great impact on the quality of life. Functional endoscopic sinus surgery is the treatment of choice for chronic rhinosinusitis refractory to medical treatment as it allows restoring ventilation and mucociliary clearance. Sino-Nasal Outcome Test 22 questionnaire has been used for evaluating changes in symptoms and predicting the extent of postoperative outcome. Objective: The aim of the study was to evaluate how functional endoscopic sinus surgery affects the outcome in patients' symptom profile and quality of life. Patients and Methods: 60 patients indicated for functional endoscopic sinus surgery from March 2017 till December 2018. This prospective study was carried out at the Otorhinolaryngology Department at El-Menoufia University Hospital. For all patients, the Sino-Nasal Outcome Test-22 was completed before and three months after Functional Endoscopic sinus surgery. Results: 60 patients were enrolled in this study (34 Males and 26 Females) aged from 25 to 40 years old with a mean age of 32.9 ± 5.3. The results of the statistical analysis showed that functional endoscopic sinus surgery reduced the Sino-Nasal Outcome Test-22 questionnaire score with a statistically high significant result (P ≤ 0.001). Conclusion: Functional endoscopic sinus surgery statistical significant improvements in disease-specific quality of life for patients with chronic rhinosinusitis.

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Section: Discussionsupporting

confidence: 93%

Evaluation of quality of life after Functional Endoscopic Sinus Surgery (FESS) in chronic rhinosinusitis patients in Menoufia Governorate

Behiry

El-Shazly

Abdelshafy

et al. 2019

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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“…The reasons for exclusion are listed in Figure . Finally, 10 studies were included for qualitative synthesis and nine studies for quantitative synthesis . Characteristics of the included studies are shown in Table .…”

Section: Resultsmentioning

confidence: 99%

Factors of success of low‐dose macrolides in chronic sinusitis: Systematic review and meta‐analysis

et al. 2019

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Objective: To assess the prognostic factors that predict favorable outcomes of low-dose macrolides (LDMs) in treating chronic rhinosinusitis (CRS).Methods: Randomized controlled trials studying the effects of LDMs in treating CRS were included. Data were pooled for meta-analysis. Primary outcome was Sino-Nasal Outcome Test (SNOT). Six prognostic factors: CRS subtypes, serum immunoglobulin (Ig)E level, membered lactone ring of macrolides, concurrent endoscopic sinus surgery (ESS), and dosage and duration of the LDMs were assessed by subgroup analyses.Results: Ten studies (608 patients) met the inclusion criteria. LDMs and placebo were not different in SNOT improvement (standardized mean difference [SMD] = −0.23, 95% confidence interval [CI]: −0.69 to 0.24). Subgroup analyses showed that the effects favored LDMs in the patients with CRS without polyps (SMD = −0.64, 95% CI: −1.01 to −0.27) compared to CRS with polyps, and the patients receiving a half dose (SMD = −0.64, 95% CI: −1.01 to −0.27) compared to a very low dose. There was no difference in SNOT improvement between LDMs plus standard treatment compared to standard treatment (SMD = −0.52, 95% CI: −1.57 to 0.53). Subgroup analyses showed that the effects favored LDMs in the patients receiving LDMs for a duration of 24 weeks (SMD = −1.68, 95% CI: −2.40 to −0.95) compared to 8 and 12 weeks. There was no difference between the 14-membered and 15-membered ring LDMs. Assessment of concurrent ESS found mixed results. Serum IgE level could not be assessed.Conclusions: LDMs provided favorable outcomes in patients with CRS without polyps. A half dose of macrolides should be given for a duration of 24 weeks.

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“…A total of 31 studies were considered to be duplicates from the same cohort, and an additional 53 failed to meet inclusion/exclusion criteria. The final study list included 40 unique patient cohorts published from 2008 to 2016 and representing institutions from North America (n = 14), Europe (n = 12), Middle East (n = 6), Australia (n = 3), Asia (n = 3), and South America (n = 2) . The majority of studies were prospective observational cohorts (n =2 3), with the remainder being surgical arms from randomized clinical trials (n = 7), retrospective cohorts (n = 7), or case‐control studies (n = 3).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies examined the association of preoperative CT scores with SNOT‐22 change scores, with one finding a positive correlation and the other two showing no impact . Sex and age were each evaluated by three studies with none showing any association. Other factors of interest included allergy, asthma, revision surgery, depression, tobacco use, preoperative SNOT‐22 score, and length of follow‐up.…”

Section: Resultsmentioning

confidence: 99%

Sino‐Nasal outcome test‐22 outcomes after sinus surgery: A systematic review and meta‐analysis

Soler

Jones

et al. 2017

The Laryngoscope

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Long-term Postoperative Azithromycin in Patients with Chronic Rhinosinusitis: A Randomized Clinical Trial

Cited by 47 publications

References 23 publications

Evaluation of quality of life after Functional Endoscopic Sinus Surgery (FESS) in chronic rhinosinusitis patients in Menoufia Governorate

Evaluation of quality of life after Functional Endoscopic Sinus Surgery (FESS) in chronic rhinosinusitis patients in Menoufia Governorate

Factors of success of low‐dose macrolides in chronic sinusitis: Systematic review and meta‐analysis

Sino‐Nasal outcome test‐22 outcomes after sinus surgery: A systematic review and meta‐analysis

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