Long-term posterior and anterior segment complications of immune recovery uveitis associated with cytomegalovirus retinitis

Karavellas, Marietta P.; Song, Mi-Kyoung; Macdonald, Jonathan; Freeman, William R.

doi:10.1016/s0002-9394(00)00528-6

Cited by 78 publications

(27 citation statements)

References 21 publications

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“…The clinical fi ndings include anterior segment infl ammation, sometimes with iris synechiae and complicated cataract, vitritis, cystoid macular edema (CME) and epiretinal membrane formation. [11][12][13][14][15][16][17][18] Preretinal neovascularization, papillitis, proliferative vitreoretinopathy, vitreomacular traction, may also be present in small number of patients. 11,12,14,16,17 ( Figure 2).…”

Section: Ocular Examinationmentioning

confidence: 99%

“…14 Several treatment options for patients with IRU and macular edema have been proposed. Physicians have suggested the use of corticosteroids 28,29 for the management of IRU and in cases of infectious etiology, specifi c therapy is indicated.…”

Section: Management Medical Managementmentioning

confidence: 99%

“…(Table 1) ISSN 0972-0200 vitreoretinopathy, severe postoperative infl ammation, and posterior synechiae. 14 Kempen et al 25 reported that eyes with IRU are at higher risk for moderate visual loss as compared to those without IRU.…”

Section: Management Medical Managementmentioning

confidence: 99%

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Immune Recovery Uveitis

Balamurugan¹

2015

DJO

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Section: Ocular Examinationmentioning

confidence: 99%

Section: Management Medical Managementmentioning

confidence: 99%

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Immune Recovery Uveitis

Balamurugan¹

2015

DJO

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“…Patients may note blurred vision, floaters, a loss of visual acuity (22) or, sometimes, ocular pain. Eye examinations may show cystoid macular edema, epiretinal membrane, proliferative vitreoretinopathy, spontaneous vitreal hemorrhage, posterior subcapsular cataracts or persistent anterior chamber inflammation (23). Treatment with topical steroids alone often suffices.…”

Section: Immune Recovery Uveitismentioning

confidence: 99%

Canadian Consensus Guidelines for the Management of Cytomegalovirus Disease in HIV/AIDS

Lalonde¹,

Bovivin²,

Deschênes³

et al. 2004

Canadian Journal of Infectious Diseases and Medical Microbiolog

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BACKGROUND: The management of HIV-infected patients with cytomegalovirus (CMV) disease has changed significantly with the availability of highly active antiretroviral therapy (HAART).OBJECTIVES: These updated guidelines are intended to provide practical help to physicians managing HIV-positive patients with or at risk for CMV disease.METHODS: The 10 members of the Canadian CMV Disease in HIV/AIDS Consensus Group were infectious disease specialists, a primary care physician and ophthalmologists with expertise in HIV and CMV infection. Financial support by Hoffmann-La Roche Canada Ltd was unrestricted, and was limited to travel expenses and honoraria. The consensus group met in June and October 2002. Key areas to be considered were identified, and group members selected, reviewed and presented relevant recent literature for their assigned section for the group's consideration. Evidence was assessed based on established criteria, which were expert opinions of the members. Draft documents were circulated to the entire group and modified until consensus was reached. The final guidelines represent the group's consensus agreement. The guidelines were approved by the Canadian Infectious Disease Society.RESULTS AND CONCLUSIONS: The guidelines address symptom monitoring, screening for early detection and prevention, and treatment using oral, intravenous and intraocular anti-CMV therapies in conjunction with HAART.

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“…All patients had a history of cytomegalovirus retinitis. Immune recovery uveitis is manifested as a vitritis, with frequent occurrence of visually significant complications including cystoid macular edema, fibrous proliferation within the eye, and cataract (17). The pathogenic mechanisms responsible for immune recovery uveitis remain uncertain, but it is accepted that this represents an immune response against intraocular cytomegalovirus antigen(s) in a patient with improving immune function following initiation of antiretroviral therapy (12).…”

Section: Smith and Rosenbaummentioning

confidence: 99%