Long‐term plasma levels of leptin and adiponectin in Rett syndrome

Blardi, Patrizia; Lalla, A. De; D'Ambrogio, Tatiana; Vonella, Giuseppina; Ceccatelli, L.; Auteri, Alberto; Hayek, Joussef

doi:10.1111/j.1365-2265.2008.03386.x

Cited by 44 publications

(40 citation statements)

References 26 publications

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“…This suggests that adipokines in Rett syndrome may be differentially regulated. Blardi et al [15] repeated their experiments including autistic patients besides Rett patients, but they did not find significant differences in adiponectin levels in spite of increased leptin levels in patients with ASD. …”

Section: Discussionmentioning

confidence: 99%

Changes in Adipokine Levels in Autism Spectrum Disorders

et al. 2013

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Background and Objective: The etiopathogenesis of autism spectrum disorders (ASD) is largely unknown, but it seems to involve dysfunction in several biological systems. Among many possible biological pathways, the immune system has emerged as potentially involved. Recent studies have shown association between cytokines (molecules that mediate immune cell interaction) and ASD. Adipokines are cytokines secreted mainly by adipose tissue and may have systemic effects. The main objective of this study was to compare the plasma levels of three adipokines between patients with ASD and healthy controls. Another aim was to correlate the levels of these adipokines and the severity of autistic symptoms as measured by the Social Responsiveness Scale (SRS). Methods: We collected plasma from 30 patients and 19 controls and measured the levels of adiponectin, leptin and resistin using a commercially available kit. We also used the SRS as a tool to assess the severity of autistic symptoms. Results: We found decreased levels of resistin, increased levels of leptin and unaltered levels of adiponectin in plasma from ASD subjects in comparison with controls. There was also a negative correlation between the levels of adiponectin and the severity of symptoms as assessed by the SRS. Conclusion: There are significant changes in the plasma levels of adipokines from patients with ASDs. They suggest the occurrence of systemic changes in ASD and may be hallmarks of the disease.

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Section: Discussionmentioning

confidence: 99%

Changes in Adipokine Levels in Autism Spectrum Disorders

et al. 2013

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“…This phenotype suggests a classical leptin-resistant state, as would be encountered in the presence of elevated PTP1B, consistent with a role for the phosphatase in contributing to RTT pathogenesis. Interestingly, plasma levels of leptin have also been shown to be markedly elevated in patients with RTT (47,48), which is one of the hallmarks of leptin resistance that is observed in metabolic disorders. However not all patients with elevated leptin levels were obese, which suggests that leptin accumulation in patients with RTT could be related to factors other than weight control and adiposity and that correcting circulating levels of leptin could have a beneficial effect on other aspects of RTT.…”

Section: Inhibition Of Ptp1b Ameliorated Symptoms Of Rtt In Mecp2mentioning

confidence: 99%

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

Krishnan¹,

Krishnan²,

Connors³

et al. 2015

J. Clin. Invest.

101

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“…Blardi et al [ 3 ] measured leptin − a peptide hormone that is proportional to body fat − over a period of 2 years in normal weight girls with RS and normal weight controls. Across the measurement period the leptin levels of the girls with RS were signifi cantly higher than those of the controls, and showed a signifi cant increase over the 2-year measurement period.…”

Section: Discussion ▼mentioning

confidence: 99%

Increased Resting Metabolic Rate in Girls with Rett Syndrome Compared to Girls with Developmental Disabilities

et al. 2011

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The aim of this study was to determine the body composition and resting metabolic rate (RMR) of girls with Rett syndrome (RS) (n=15) and to compare them with an equally handicapped group of girls with developmental disabilities (DD) (n=13). Body composition was measured by bioelectrical impedance analysis and RMR - the amount of energy expended while at rest - by indirect calorimetry. Weight, height, body mass index (BMI), BMI percentiles and food intake were all measured and calculated by standardized procedures. Feeding time, ambulatory status and ability to self-feed were also assessed. Due to the sampling, there were no significant differences in age, height, weight, BMI, BMI percentiles and ambulatory status. Significant differences between groups were found for lower percentage lean body mass (LBM) (64.2±14.6 vs. 84.4±24.6) and higher absolute and relative fat mass (FM) in RS. RMR values adjusted for LBM were significantly higher in the group of girls with RS (approximately 160 kcal/day), indicating that higher energy expenditure is a component of increased risk of severely low body weight.

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Long‐term plasma levels of leptin and adiponectin in Rett syndrome

Abstract: Since all patients were not obese, we might hypothesize that in Rett syndrome leptin and adiponectin might participate to clinical manifestations other than weight balance.

Cited by 44 publications

References 26 publications

Changes in Adipokine Levels in Autism Spectrum Disorders

Changes in Adipokine Levels in Autism Spectrum Disorders

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

Increased Resting Metabolic Rate in Girls with Rett Syndrome Compared to Girls with Developmental Disabilities

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