Long-Term Physical Exercise and Lipoprotein(a) Levels in a Previously Sedentary Male and Female Population

Ponjee, G. A. E.; Janssen, E.; Wersch, J. W. J. Van

doi:10.1177/000456329503200208

Cited by 18 publications

(14 citation statements)

References 32 publications

(5 reference statements)

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“…A recent meta-analysis concluded that Lp(a) was an independent and modest risk factor for coronary heart disease and stroke [ 28 ]. Results of previous studies investigating the effect of exercise on Lp(a) concentration are controversial [ 29 – 34 ]. Rigla et al reported a significant decrease in Lp(a) concentration in diabetic patients with higher baseline Lp(a) (> 9 mg/dl) after a 3-month physical exercise program [ 35 ], and Muls et al reported that substantial weight loss in obese women resulted in lower Lp(a) concentration [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of Low-Intensity Resistance Training with Body Composition and Lipid Profile in Obese Patients with Type 2 Diabetes

et al. 2015

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Resistance training to increase muscle mass and functional capacity is an integral part of diet and exercise programs for the management of obesity and type 2 diabetes. Low-intensity resistance training with slow movement and tonic force generation (LST) may be a practical and safe regimen for elderly obese individuals but the health benefits are uncertain. This study investigated the effects of LST on body composition and metabolic parameters in obese patients with type 2 diabetes. Twenty-six obese patients with type 2 diabetes engaged in LST training during hospitalization and were advised to maintain this regimen for 12 weeks after discharge. We compared lipid profile, arterial stiffness, and body composition before and after LST training. After 12 weeks of LST training, the ratio of lower extremity muscle mass to body weight increased significantly (0.176 ± 0.028 to 0.184 ± 0.023, mean ± SD), while body fat mass and body fat percentage decreased significantly (36.2 ± 10.9 kg to 34.3 ± 9.4 kg and 41.2 ± 8.6% to 40.1 ± 7.7%, respectively). Moreover, high-density lipoprotein cholesterol was significantly increased (42.2 ± 14 mg/dl to 46.3 ± 12.4 mg/dl) and both free fatty acids and lipoprotein(a) were decreased (665.2 ± 212.1 μEq/l to 525.4 ± 231.3 μEq/l and 15.4 ± 18 mg/dl to 13.8 ± 18 mg/dl, respectively). No significant change was observed in arterial stiffness. Although this study was a non-controlled investigation and some confounding factors including dietary intake, medication and compliance with training might affect the study result, a brief (12-week) LST training program may be a safe and effective strategy for the management of obesity and type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Associations of Low-Intensity Resistance Training with Body Composition and Lipid Profile in Obese Patients with Type 2 Diabetes

et al. 2015

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“…The results of the present study focus on the important interplay between primary risk factors, like blood pressure and lipid levels with fibrinolysis (54). The changes in the haemostatic, fibrinolytic and lipid status as a result of long-term training programme has been separately discussed before (56)(57)(58)(59). The fall in plasma plasminogen activator inhibitor levels, observed in both men and women and the significant decrease in total cholesterol, LDL cholesterol and triacylglycerols in the group of men after nine months of training are known favourable effects of physical conditioning (26,27,30,33,63).…”

Section: Discussionmentioning

confidence: 97%

Regular Physical Activity and Changes in Risk Factors for Coronary Heart Disease: A Nine Months Prospective Study

Ponjee¹,

Janssen²,

Hermans³

et al. 1996

CCLM

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This study reports the non-acute effects of a long-term training programme of increasing intensity on some cardiovascular risk factors and the interrelation between these risk factors. Twenty sedentary men and 14 sedentary women were trained 3 to 4 times a week for nine months. After 36 weeks all individuals ran a half marathon run. The W max , weight, body mass index, systolic and diastolic blood pressure were recorded. The concentrations of fibrinogen, tissue plasminogen activator, plasminogen activator inhibitor, triacylglycerols, total cholesterol, LDL cholesterol, HDL cholesterol and lipoprotein(a) were measured. The training programme induced a median increase in W raax of 12% in the male group (from 226 to 251.5 Watt) and of 18% in the female group (from 160 to 188.5 Watt). These increases in W max did not correlate with any other property under investigation in this study. Blood pressure was not altered, but body weight and body mass index were significantly decreased in the male group (from 74.6 to 72.2 kg and from 23.1 to 22.0 kg/m 2 , respectively) at the end of the training programme and decreased non-significantly in the female group (from 63.0 to 60.7 kg and from 21.6 to 21.5 kg/m 2 , respectively). In the male group total cholesterol, low density lipoprotein cholesterol and triacylglycerols decreased significantly under the influence of the training sessions. Furthermore, in both groups, a great decrease in plasma plasminogen activator inhibitor concentrations was noticed: in men from 22.5 · 10 3 AU/1 to 4.5 · 10 3 AU/1 and in women from 18.7 · 10 3 AU/1 to 5.1 · 10 3 AU/1. However, the changes in the lipid and fibrinolytic quantities were not correlated with each other. Initial total cholesterol, LDL cholesterol and triacylglycerol levels correlated significantly with systolic blood pressure, while diastolic pressure was correlated to tissue plasminogen activator. Since tissue plasminogen activator also was significantly related to triacylglycerols, a trias existed between primary risk factors like blood pressure, lipid levels and fibrinolysis. In contrast, the changes in these properties under the influence of physical training were not interrelated. Median serum lipoprotein(a) concentrations were significantly increased in both men and women five days before the half marathon run: from 32 mg/1 to 39 mg/1 in men, and from 65 mg/1 to 125.5 mg/1 in women. Concomitantly, median fibrinogen concentrations were significantly elevated in men (from 2.32 g/1 to 3.10 g/1) and non-significantly in women (from 2.62 g/1 to 2.93 g/1), although no correlation existed between the changes in these properties.In conclusion, the nine months exercise programme increased the aerobic fitness in both men and women as indicated by the W max increase. This improvement coincided but was not correlated with beneficial changes in several anthropometric, lipid and fibrinolytic properties. Improvement in the risk factors under investigation was more pronounced in men than in women. The changes in lipid and haemostasis propert...

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“…For example, in a study of 37 healthy women fed two low-fat diets, one low in vegetable content and the other high in vegetable content, they experienced a 7% and 9% increase in Lp(a), respectively [ 11 ]. Sustained physical exercise can increase Lp(a) levels by 10% for moderate exercise and up to over 100% for high-endurance athletes [ 12 – 15 ]. The rise in Lp(a) during exercise is likely as an acute-phase reactant in response to soft tissue damage in the musculature and vasculature during repeated movements.…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein(a) and Cardiovascular Disease Prevention across Diverse Populations

Pearson

Rodríguez

2020

Cardiol Ther

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Lipoprotein(a) (Lp(a)) is a highly proatherogenic lipid fraction that is genetically determined and minimally responsive to lifestyle or behavior changes. Mendelian randomization studies have suggested a causal link between elevated Lp(a) and heart disease, stroke, and aortic stenosis. There is substantial inter-ethnic variation in Lp(a) levels, with persons of African descent having the highest median values. Monitoring of Lp(a) has historically been limited by lack of standardization of assays. With the advent of novel therapeutic modalities to lower Lp(a) levels including proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors and targeted antisense oligonucleotides, it is increasingly important to screen patients who have family or personal history of atherosclerotic cardiovascular disease for elevations in Lp(a). Further study is needed to establish a causal relationship between elevated Lp(a) and cardiovascular disease across diverse ethnic populations.

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Long-Term Physical Exercise and Lipoprotein(a) Levels in a Previously Sedentary Male and Female Population

Cited by 18 publications

References 32 publications

Associations of Low-Intensity Resistance Training with Body Composition and Lipid Profile in Obese Patients with Type 2 Diabetes

Associations of Low-Intensity Resistance Training with Body Composition and Lipid Profile in Obese Patients with Type 2 Diabetes

Regular Physical Activity and Changes in Risk Factors for Coronary Heart Disease: A Nine Months Prospective Study

Lipoprotein(a) and Cardiovascular Disease Prevention across Diverse Populations

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