Long-term Physical and Psychological Outcomes of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Abstract

IMPORTANCEStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is known to cause multiple end-organ complications in its acute phase, but less is known about the long-term association with patients' mental health and quality of life.OBJECTIVE To examine the chronic physical and psychological sequelae affecting patients with SJS/TEN.

Psychotherapeutic interventions for burns patients and the potential use with Stevens-Johnson syndrome and toxic epidermal necrolysis patients: A systematic integrative review

“…Whilst there is a dearth of studies relating to the psychological impact of SJS/TEN on patients’ lives, the existing studies acknowledges the range of psychological effects on patients’ well-being such as anxiety, depression and PTSD [ 14 – 19 , 21 , 22 ]. The psychological sequelae of burns are well documented.…”

“…Furthermore, some SJS/TEN patients sustain feelings of distress and reveal Post-Traumatic Stress (PTS) symptoms [ 18 , 21 ], while others experienced anxiety and depression [ 17 – 19 ]. A recent study of SJS/TEN survivors (n = 121) found that 43.3% of participants screened positive for anxiety, 53.3% presented with a positive depression screen, and 19.5% had positive screening for PTS [ 22 ]. Dodiuk-Gad et al [ 18 ] in their study of SJS/TEN survivors (n = 17), found that even though many of the individuals presented with psychological sequelae only four were assessed by a mental health practitioner following diagnosis with SJS/TEN.…”

Quoi de neuf en dermatologie clinique ?

“…Les nécrolyses épidermiques toxiques (Stevens-Johnson et Lyell) ont des séquelles physiques à long terme dans plus de 50 % des cas (cutanées, oculaires et buccales) et des séquelles psychologiques fréquentes, syndromes dépressifs, anxiété, syndrome post-traumatique et la peur des nouveaux médicaments [ 62 ]. De nouveaux responsables de nécrolyse épidermique ont été identifiés dans la base de données VIGIBASE de l’Organisation mondiale de la santé (OMS) (pharmacovigilance de 131 pays).…”

A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

“…The most common sequalae are skin and mucosal problems. Hoffman et al reported the prevalence of physical sequalae relevant to SJS/TEN, including cutaneous problems (84.3%), ocular problems (59.5%), and oral mucosal problems (50.8%) [ 5 ]. Skin hyperpigmentation, scarring, hair loss, and nail dystrophy are also common.…”

“…Psychological problems including anxiety, depression, and post-traumatic stress disorder have also been reported in these patients. According to a study, the physical and psychological sequelae of SJS/TEN caused lack of ability to work in 28.2% patients, and 68.1% and 30.0% patients were fearful or avoided taking medications, respectively [ 5 ].…”