Long-term physical activity modulates adipsin and ANGPTL4 serum levels, a potential link to exercise-induced metabolic changes

Lenz, Max; Schönbauer, Robert; Stojković, Stefan; Lichtenauer, Michael; Paar, Vera; Gatterer, Constantin; Schukro, Christoph; Emich, Michael; Fritzer‐Szekeres, Monika; Strametz-Juranek, Jeanette; Sponder, Michael

doi:10.23736/s0031-0808.21.04382-2

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Имеются данные о положительном влиянии регулярных аэробных физических нагрузок на уровень адипсина [26].…”

Section: регуляция уровня адипсинаunclassified

“…По мнению M. Lenz и соавт., наличие взаимосвязи между аэробными физическими нагрузками и повышением продукции адипсина может указывать на то, что адипсин является связующим звеном между балансом триглицеридов и потребностями в энергии [26].…”

Section: интерференция: адипсин-адипоциты-инсулин-глюкозаunclassified

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Adipsin – summing up large-scale results: A review

2022

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Adipsin is one of the first discovered adipokines hormones produced by adipose tissue. Adipsin performs the function of a regulator of carbohydrate and lipid metabolism and participates in the adaptation of metabolism to the real needs of the body, being a powerful stimulant of anabolic processes. A characteristic feature of adipsin is that it is also a complement factor D, which is necessary for the normal functioning of an alternative pathway of activation of the complement system. Due to this, adipsin is represented in the body as a link between the energy block of the endocrine system and the humoral block of the immune system. Adipsin is known as a regulator of the function of pancreatic beta cells, a stimulator of lipogenesis, a modulator of inflammation processes. Recently, there have been works indicating the effect of adipsin on the microbiota, as well as its role in non-alcoholic fatty liver disease. To date, there are a large number of publications describing the biochemical structure, functions of adipsin, mechanisms of regulation of its synthesis, as well as changes in the level of adipsin in various pathological conditions. Attempts are also described to pharmacologically influence adipsin in order to modulate its functions or use it as a biomarker for the diagnosis of diseases. However, there is currently no structured review that summarizes and systematizes all available information about this adipokine. This is exactly the task we set ourselves in this study. The paper contains the results of all available studies on adipsin. In some cases, they are contradictory in nature, which indicates the need for further research in detecting connections between the body's systems.

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Section: регуляция уровня адипсинаunclassified

Section: интерференция: адипсин-адипоциты-инсулин-глюкозаunclassified

Adipsin – summing up large-scale results: A review

2022

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“…The influence of increased physical activity on inflammation and lipid metabolism biomarkers such as sTWEAK/sCD163, sRAGE, and adipsin/ANGPTL4 has already been investigated by our group [ 24 , 25 , 26 ]. In the present study, we aimed to illuminate the effect of long-term exercise on RANTES and CD40L.…”

Section: Introductionmentioning

confidence: 99%

RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity

Lenz

Schönbauer

Stojković

et al. 2022

IJERPH

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Regular physical exercise was found to be associated with an improved immune response in previous studies. RANTES and CD40L play a pivotal role in host defense, and individuals lacking adequate expression are prone to virus and opportunistic infections. A total of 98 participants were enrolled in this study. The probands were asked to perform moderate physical activity, and bicycle stress tests were performed at the baseline and after 8 months of training to evaluate individual performance. RANTES and CD40L were found to be increased by long-term physical exercise. In particular, probands with a performance gain of ≥3% displayed a pronounced elevation of both markers, paired with a decrease in circulating IL6 levels and an improved lipid profile. In summary, we were able to highlight rising levels of serum RANTES and CD40L under the conditions of physical exercise. Taking their role in host defense into account, a conjunction of physical activity and the adaptive immune system could therefore be assumed. Furthermore, low inflammatory profiles in probands with a significant performance gain suggest a modulation through exercise rather than a generalized pro-inflammatory status.

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Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis

Birjandi

Sharafi

Etemadizade

et al. 2022

Hormone Molecular Biology and Clinical Investigation

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Objectives Immobility and its physiological and psychological consequences are common problems in patients with multiple sclerosis. The aim of this study was to investigate the effect of 8 weeks of combined training on Adipsin and lipid profile and the possible relationship between these indicators and psychological function in women with multiple sclerosis. Methods In this quasi-experimental study, 40 women with multiple sclerosis were selected by purposeful sampling method and randomly divided into two equal control and exercise groups (n=20). Exercise was performed for 8 weeks (two resistance sessions and one endurance session per week). Before and after the intervention, blood samples were taken and the DASS-21 questionnaire was completed to assess anxiety, depression and stress. Data were analyzed using analysis of covariance, t-test, Bonferroni post hoc test and Pearson correlation test at a significance level of p≤0.05. Results In the exercise group, levels of Adipsin, total cholesterol, LDL, TG, weight, fat percentage, WHR, BMI, depression, anxiety and stress were significantly reduced and HDL levels were significantly increased after 8 weeks of combined exercise (p≤0.05). Also, BMI (p=0.01), fat percentage (p=0.01) and WHR (p=0.01) levels had significant positive correlation with Adipsin. There was a significant positive relationship between Total cholesterol level with depression index (p=0.04). Conclusions Performing combination exercises through improving body composition can increase the risk of obesity and cardiovascular risk factors and improve the psychological function of patients with multiple sclerosis. Specialists can use these exercises as an adjunct to drug therapy for MS patients.

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Long-term physical activity modulates adipsin and ANGPTL4 serum levels, a potential link to exercise-induced metabolic changes

Cited by 3 publications

References 30 publications

Adipsin – summing up large-scale results: A review

Adipsin – summing up large-scale results: A review

RANTES and CD40L under Conditions of Long-Term Physical Exercise: A Potential Link to Adaptive Immunity

Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis

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