Long-Term Physical Activity and Risk of Age-Related Cataract

Selin, Jinjin Zheng; Orsini, Nicola; Lindblad, B. S.; Wolk, Alicja

doi:10.1016/j.ophtha.2014.08.023

Cited by 35 publications

(22 citation statements)

References 22 publications

(22 reference statements)

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“…Previous evidence on the potential effect of physical activity is sparse, with only 3 prospective studies having been carried out, 30 , 31 and only 1 in the general population. 32 The evidence from our study of a slightly lower risk associated with doing some strenuous physical activity agrees with previous evidence. However, this lower risk associated with physical activity could be due to reverse causation bias, because women with cataracts might be less likely to participate in strenuous physical activity because of visual impairment.…”

Section: Discussionsupporting

confidence: 92%

Risk Factors for Cataracts Treated Surgically in Postmenopausal Women

et al. 2016

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PurposeTo identify risk factors for cataracts treated surgically in postmenopausal women.DesignPopulation-based, prospective cohort study.ParticipantsA total of 1 312 051 postmenopausal women in the UK Million Women Study, aged 56 years on average (standard deviation [SD], 4.8), without previous cataract surgery, hospital admission with cataracts, or cancer at baseline, were followed for cataracts treated surgically.MethodsCox regression was used to calculate adjusted relative risks (RRs) for cataract surgery by lifestyle factors, treatment for diabetes, reproductive history, and use of hormonal therapies.Main Outcome MeasuresCataract surgery identified by linkage to central National Health Service (NHS) records for inpatient and day-patient admissions (Hospital Episode Statistics for England and Scottish Morbidity Records in Scotland).ResultsOverall, 89 343 women underwent cataract surgery during an average of 11 (SD, 3) years of follow-up. Women with diabetes were at greatest risk (diabetes vs. no diabetes RR, 2.90; 95% confidence interval [CI], 2.82–2.97). Other factors associated with an increased risk of cataract surgery were current smoking (current smokers of ≥15 cigarettes/day vs. never smokers RR, 1.26; 95% CI, 1.23–1.30) and obesity (body mass index [BMI] ≥30 vs. <25 kg/m2; RR, 1.12; 95% CI, 1.10–1.14).ConclusionsDiabetes, smoking, and obesity were risk factors for cataract surgery. Alcohol use, physical activity, reproductive history, and use of hormonal therapies had little, if any, association with cataract surgery risk.

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Section: Discussionsupporting

confidence: 92%

Risk Factors for Cataracts Treated Surgically in Postmenopausal Women

et al. 2016

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“…Other previously reported factors (e.g. gender, self-assessment for understanding of cataract, long-term residence, exposure to sun light, smoking, alcohol consumption, tea consumption, physical activity, body mass index) were not found to be significantly different between cases and controls in this study ( 36 – 38 ).…”

Section: Discussioncontrasting

confidence: 68%

Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province

Gao²,

Wu³

et al. 2015

Food & Nutrition Research

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Background/objectivesEpidemiological evidence suggests that diets rich in flavonoids may reduce the risk of developing age-related cataract (ARC). Flavonoids are widely distributed in foods of plant origin, and the objective of this study was to evaluate retrospectively the association between the intakes of the five flavonoid subclasses and the risk of ARC.Subjects/methodsA population-based case-control study (249 cases and 66 controls) was carried out in Heilongjiang province, which is located in the northeast of China, and where intakes and availability of fresh vegetables and fruits can be limited. Dietary data gathered by food-frequency questionnaire (FFQ) were used to calculate flavonoid intake. Adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by logistic regression.ResultsNo linear associations between risk of developing ARC and intakes of total dietary flavonoids, anthocyanidins, flavon-3-ol, flavanone, total flavones or total flavonols were found, but quercetin and isorhamnetin intake was inversely associated with ARC risk (OR 11.78, 95% CI: 1.62–85.84, p<0.05, and OR 6.99, 95% CI: 1.12–43.44, p<0.05, quartile 4 vs. quartile 1, respectively).ConclusionAs quercetin is contained in many plant foods and isorhamnetin in very few foods, we concluded that higher quercetin intake may be an important dietary factor in the reduction of the risk of ARC.

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“…Therefore, we should consider the possibility that co-morbidity has affected cataract formation [ 39 ]. Zheng et al reported that Leisure time inactivity (< 1 h/day) was associated with increased risk of cataract [ 20 ]. However, they did not perform sub-group analysis of non-exerciser and any amount of exercise group, especially less than an hour daily.…”

Section: Discussionmentioning

confidence: 99%

“…Over 1200 predictor variables were obtained by health screening examination. According to previous reports [ 10 – 16 ], 42 of these predictors known to be associated with cataract were selected for the analysis: age [ 14 ], sex [ 17 ], history of smoking [ 18 ], alcohol consumption [ 19 ], physical exercise [ 20 ], diabetes [ 21 ], asthma [ 22 , 23 ], tuberculosis [ 24 ], hypertension [ 25 ], dyslipidemia [ 26 ], medication use such as statin [ 27 ] or aspirin [ 28 ] as reported by a self-questionnaire, height, weight, body mass index (BMI, kg/m 2 ) [ 29 ], waist circumference, and blood tests including markers of diabetes, dyslipidemia, inflammation [ 30 ], dehydration [ 31 ], iron deficiency [ 32 ], and viral infection [ 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Risk factors of presenile nuclear cataract in health screening study

et al. 2018

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BackgroundTo identify risk factors for the development of presenile nuclear cataract in health screening test.MethodsThe cross sectional study included a total of 532 eyes of 266 participants aged 30 to 49 years of Samsung Medical Center from February 2013 to April 2015. Presence of nuclear cataract was defined when the log MAR visual acuity with correction was greater than or equal to 0.2 and one or more of the following were met: Pentacam Nuclear Staging (PNS) grading score ≥ 1, average value of nuclear density ≥ 15%, maximum value of nuclear density ≥ 30%. Possible risk factors were obtained from blood tests and questionnaires of a health screening test of Samsung Medical Center. Association between nuclear cataract and risk factors was investigated using univariate and multivariate logistic regression analysis by generalized estimating equation (GEE) models.ResultsFive factors were significantly associated with presenile nuclear cataract: current smoking [odds ratio (OR) = 2.80, 95% confidence interval (CI), 1.10–7.12, p = 0.0310], non-exercise and high amount of daily physical exercise (OR = 3.99, 95% CI, 1.27–12.52, p = 0.0178; OR = 2.92, 95% CI, 1.38–6.22, p = 0.0053), asthma (OR = 8.93, 95% CI, 1.12–71.15, p = 0.0386), tuberculosis (OR = 4.28, 95% CI, 1.36–13.50, p = 0.0131), and higher total iron binding capacity (OR = 1.01, 95% CI, 1.00–1.02, p = 0.0059).ConclusionsPresenile nuclear cataract is related to current smoking, non-exercise or high amount of physical exercise, asthma, tuberculosis, and iron deficiency status. The association of non-exercise group and presenile nuclear cataract seems to be related to co-morbidity. Patients with asthma, tuberculosis, or iron deficiency anemia are recommended to receive frequent ophthalmic examination to detect cataract.Electronic supplementary materialThe online version of this article (10.1186/s12886-018-0928-6) contains supplementary material, which is available to authorized users.

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Long-Term Physical Activity and Risk of Age-Related Cataract

Cited by 35 publications

References 22 publications

Risk Factors for Cataracts Treated Surgically in Postmenopausal Women

Risk Factors for Cataracts Treated Surgically in Postmenopausal Women

Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province

Risk factors of presenile nuclear cataract in health screening study

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