Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

Couette, Maryline; Boissé, Marie-Françoise; Maison, Patrick; Brugières, Pierre; Césaro, P.; Chevalier, Xavier; Gherardi, Romain K.; Bachoud‐Lévi, Anne‐Catherine; Authier, François‐Jérôme

doi:10.1016/j.jinorgbio.2009.08.005

Cited by 84 publications

(60 citation statements)

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“…Clinical manifestations associated with MMF typically include arthromyalgias, chronic fatigue, and a cognitive dysfunction, occurring several months or years after the last vaccine injection combining impaired verbal long-term memory, dysexecutive syndrome, and more rarely an alteration of dichotic listening [3][4][5][6]. Only a very limited number of functional studies using the Single-Photon Emission Computed Tomography (SPECT) technique have investigated these cognitive disorders.…”

Section: Introductionmentioning

confidence: 99%

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Gucht¹,

Aoun-Sebaiti

Kauv

et al. 2015

Nucl Med Mol Imaging

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Brain Positron Emission Tomography/Computed Tomography with 18 F-fluorodeoxyglucose (FDG PET/CT) was performed in a 44-year-old woman with marked cognitive impairment, diffuse myalgias, sensory, memory and visual disorders, and chronic fatigue, presenting with histopathological features of macrophagic myofasciitis (MMF) at deltoid muscle biopsy. Cerebromedullary Magnetic Resonance Imaging (MRI), electromyography, ophthalmic examination, and cerebrospinal fluid analysis were normal. Visual analysis of FDG PET/CT images showed an atypical pattern of hypometabolism, involving symmetrically the occipital cortex, temporal lobes, and limbic system (including in particular amygdalo-hippocampal complexes), and the cerebellum. Posterior cingulate cortex and parietal areas were preserved. This pattern was confirmed by a voxel-based procedure using Statistical Parametric Mapping (SPM12) that compared a patient's images to normal reference samples from six healthy subjects with adjustment to age obtained using the same PET/CT camera. These results provide a glucose metabolism substrate for cognitive complaints in patients with long-lasting aluminium hydroxide-induced MMF.

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Section: Introductionmentioning

confidence: 99%

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Gucht¹,

Aoun-Sebaiti

Kauv

et al. 2015

Nucl Med Mol Imaging

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“…Abnormal neurological signs have also been seen in some patients receiving intramuscular injections of Al-containing vaccines (Couette et al, 2009). In consequence, the World Health Organization (WHO) Vaccine Safety Advisory Committee has recognized that there may be a subset of predisposed individuals who may be sensitive to Al adjuvants (Authier et al, 2001).…”

Section: Transitory Exposure To High Levels Of Aluminum Can Results Inmentioning

confidence: 99%

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Bondy

2016

NeuroToxicology

201

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“…Indeed, chronic pain, chronic fatigue states, and depressive syndromes are known to impair intellectual or cognitive performance. The prevalence of cognitive complaints ranged from 20% to 68% (4,(7)(8)(9)(10). MMF-associated cognitive dysfunction resembles that observed after chronic exposure to aluminum and in patients infected with hepatitis C virus or HIV (7).…”

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confidence: 88%

“…The prevalence of cognitive complaints ranged from 20% to 68% (4,(7)(8)(9)(10). MMF-associated cognitive dysfunction resembles that observed after chronic exposure to aluminum and in patients infected with hepatitis C virus or HIV (7). At follow-up, it appears stable over time, both in structure and in severity (11).…”

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confidence: 90%

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Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Gucht¹,

Sebaiti²,

Guedj³

et al. 2016

J Nucl Med

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The aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with 18 F-FDG. Methods: 18 F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean 6 SD], 45.9 6 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all 18 F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 6 16 y; P 5 0.87) and sex (73% women; P 5 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment (n 5 42), those with frontal subcortical (FSC) dysfunction (n 5 29), those with Papez circuit dysfunction (n 5 22), and those with callosal disconnection (n 5 7). Results: In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism (P , 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size. Conclusion: Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.

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Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

Cited by 84 publications

References 44 publications

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

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Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

Cited by 84 publications

References 44 publications

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

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Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis