Long-Term Persistence of Subfoveal Fluid Following Ocriplasmin-Treatment of an FTMH

Tschuppert, Scott; Gerding, H.

doi:10.1055/s-0043-100559

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…5 Longer-term persistence of subfoveal fluid following ocriplasmin treatment is also described. 6 The enzymatic activity of ocriplasmin includes its action on the protein components (e.g. laminin, fibronectin and collagen) of the vitreous and vitreoretinal interface, thereby facilitating vitreous liquefaction and separation of vitreous from retina.…”

Section: Case Presentationmentioning

confidence: 99%

“…However longer persistence with only partial recovery is also described. 6 The use of oral carbonic anhydrase inhibitor is well described modality of treatment in helping resolution of neurosensory detachment in central serous chorioretinopathy. The aim is to reduce the duration of accompanying visual disability while awaiting the natural resolution.…”

Section: Introductionmentioning

confidence: 99%

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Neurosensory Macular Retinal Detachment after Intravitreal Ocriplasmin Treated Successfully with Oral Carbonic Anhydrase Inhibitor

2019

J Bah Med Soc

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Ocriplasmin is an enzymatic drug used intravitreally to lyse focal vitreomacular adhesion and traction. We present a 45-year-old Bahraini female who developed a neurosensory macular retinal detachment from subfoveal fluid collection four weeks after its successful release following an ocriplasmin intravitreal injection. Subfoveal fluid is a well-known side effect of intravitreal ocriplasmin, mostly resolving spontaneously and completely over a period of few months. In order to reduce the attendant visual disability, rather than waiting for its natural recovery, we chose to treat it with oral carbonic anhydrase inhibitor, acetazolamide with an encouraging outcome. This drug is known to help in resorption of subfoveal fluid in the condition of central serous chorioretinopathy. However, to the best of our knowledge, its role is not explored in post-ocriplasmin setting. The purpose of this case presentation is to highlight the possible beneficial role of carbonic anhydrase inhibitors in ocriplasminrelated subfoveal neurosensory detachment.

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Section: Case Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neurosensory Macular Retinal Detachment after Intravitreal Ocriplasmin Treated Successfully with Oral Carbonic Anhydrase Inhibitor

2019

J Bah Med Soc

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Ocriplasmin

2017

Reactions Weekly

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Loculated subretinal fluid after pneumatic vitreolysis

Crosson

Thomley

Chan

et al. 2019

American Journal of Ophthalmology Case Reports

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Purpose To present, to the authors’ knowledge, the first reported case of loculated subretinal fluid associated with pneumatic vitreolysis (PVL). Observations A 74 year old female was followed for 9 months with vitreomacular traction (VMT) and 20/20 visual acuity in her right eye. Her visual acuity decreased at 9 months to 20/50 and she was treated with PVL. VMT release was successful on day 7. An isolated shallow pocket of loculated subretinal fluid developed inferotemporal to the fovea at one month after PVL and persisted for 14 months. The subretinal fluid eventually resolved at 14 months after PVL, and visual acuity improved to 20/30, and there were no electroretinographic abnormalities. Conclusion and Importance Localized subretinal fluid is an unusual complication of PVL. No adverse visual outcome developed despite the persistent extrafoveal subretinal fluid in this case, and the subretinal fluid eventually resolved over a year after PVL.

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Long-Term Persistence of Subfoveal Fluid Following Ocriplasmin-Treatment of an FTMH

Cited by 4 publications

References 7 publications

Neurosensory Macular Retinal Detachment after Intravitreal Ocriplasmin Treated Successfully with Oral Carbonic Anhydrase Inhibitor

Neurosensory Macular Retinal Detachment after Intravitreal Ocriplasmin Treated Successfully with Oral Carbonic Anhydrase Inhibitor

Ocriplasmin

Loculated subretinal fluid after pneumatic vitreolysis

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