Long-term persistence after acute Q fever of non-infective Coxiella burnetii cell components, including antigens

Sukocheva, Olga; Marmion, B. P.; Storm, P.A.; Lockhart, Michelle G.; Turra, Mark; Graves, Stephen

doi:10.1093/qjmed/hcq113

Cited by 35 publications

(38 citation statements)

References 29 publications

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“…94 NAAT-based testing of surgical materials may also detect organisms associated with previous episodes of IE that were treated up to 12 years before surgery and are unrelated to the current episode. 95,96 There is little loss of sensitivity by NAAT when surgical specimens are obtained within 5 days of initiation of antibiotic therapy; treatment for several weeks before surgery will increase the false-negative rate. 93,97 Investigational approaches to the pathogenesis of CNE include tissue-culture based growth for propagation of intracellular pathogens and autoimmunohistochemistry on surgical specimens.…”

Section: Culture-negative Endocarditismentioning

confidence: 99%

Infective Endocarditis in Childhood: 2015 Update

Baltimore¹,

Gewitz²,

Baddour³

et al. 2015

Circulation

308

238

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Section: Culture-negative Endocarditismentioning

confidence: 99%

Infective Endocarditis in Childhood: 2015 Update

Baltimore¹,

Gewitz²,

Baddour³

et al. 2015

Circulation

308

238

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“…Chronic Q fever generally presents as a culture-negative endocarditis or vascular infection with a high case fatality [3]. Another important long-term effect is Q fever fatigue syndrome, which occurs in 10 to 20% of all acute Q fever cases [5].…”

Section: Introductionmentioning

confidence: 99%

“…The level of IgM increases rapidly after infection, thus is considered to be a marker of recent infection, however it can persist for many months [9], [10]. IgG levels increase a few weeks after infection, but remain detectable for years or even throughout life [5], [9].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Coxiella burnetii (Q Fever) Seropositivity in Veterinary Medicine Students

Rooij¹,

Schimmer

Versteeg

et al. 2012

PLoS ONE

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BackgroundQ fever is an occupational risk for veterinarians, however little is known about the risk for veterinary medicine students. This study aimed to assess the seroprevalence of Coxiella burnetii among veterinary medicine students and to identify associated risk factors.MethodsA cross-sectional study with questionnaire and blood sample collection was performed among all veterinary medicine students studying in the Netherlands in 2006. Serum samples (n = 674), representative of all study years and study directions, were analyzed for C. burnetii IgG and IgM phase I and II antibodies with an immunofluorescence assay (IFA). Seropositivity was defined as IgG phase I and/or II titer of 1∶32 and above.ResultsOf the veterinary medicine students 126 (18.7%) had IgG antibodies against C. burnetii. Seropositivity associated risk factors identified were the study direction ‘farm animals’ (Odds Ratio (OR) 3.27 [95% CI 2.14–5.02]), advanced year of study (OR year 6: 2.31 [1.22–4.39] OR year 3–5 1.83 [1.07–3.10]) having had a zoonosis during the study (OR 1.74 [1.07–2.82]) and ever lived on a ruminant farm (OR 2.73 [1.59–4.67]). Stratified analysis revealed study direction ‘farm animals’ to be a study-related risk factor apart from ever living on a farm. In addition we identified a clear dose-response relation for the number of years lived on a farm with C. burnetii seropositivity.Conclusions C. burnetii seroprevalence is considerable among veterinary medicine students and study related risk factors were identified. This indicates Q fever as an occupational risk for veterinary medicine students.

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“…The mechanism by which C. burnetii is cleared from the blood is not known, but the timing correlates well with the development of immune responses (5). Although recent reports have suggested that C. burnetii DNA and antigen can be detected years after an acute infection, viable organisms are thought to be eliminated more quickly (6,7). However, the time required for complete clearance of viable C. burnetii in humans is not known.…”

mentioning

confidence: 99%