Long-term patterns of adherence to medication therapy among patients with type 2 diabetes mellitus in Denmark: The importance of initiation

Jensen, Majken Linnemann; Jørgensen, Marit Eika; Hansen, Ebba Holme; Aagaard, Lise; Carstensen, Bendix

doi:10.1371/journal.pone.0179546

Cited by 23 publications

(14 citation statements)

References 37 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zaslavsky et al (30) found a U-shaped relationship in the FG/HbA 1c -frailty interaction, with both extreme high and low levels associated with frailty. The cause of this U-shaped relationship is compliance with CVD medication increases when people with diabetes have more than one prescription (31). We did not find that FG was associated with frailty trajectories.…”

Section: Discussioncontrasting

confidence: 67%

Prospective Association Among Diabetes Diagnosis, HbA1c, Glycemia, and Frailty Trajectories in an Elderly Population

et al. 2019

View full text Add to dashboard Cite

Frailty is a dynamic state of vulnerability in the elderly. We examined whether individuals with overt diabetes or higher levels of HbA 1c or fasting plasma glucose (FG) experience different frailty trajectories with aging. RESEARCH DESIGN AND METHODS Diabetes, HbA 1c , and FG were assessed at baseline, and frailty status was evaluated with a 36-item frailty index every 2 years during a 10-year follow-up among participants from the English Longitudinal Study of Ageing (ELSA). Mixed-effects models with age as time scale were used to assess whether age trajectories of frailty differed as a function of diabetes, HbA 1c , and FG. RESULTS Among 5,377 participants (median age [interquartile range] 70 [65, 77] years, 45% men), 35% were frail at baseline. In a model adjusted for sex, participants with baseline diabetes had an increased frailty index over aging compared with those without diabetes. Similar findings were observed with higher levels of HbA 1c , while FG was not associated with frailty. In a model additionally adjusted for income, social class, smoking, alcohol, and hemoglobin, only diabetes was associated with an increased frailty index. Among nonfrail participants at baseline, both diabetes and HbA 1c level were associated with a higher increased frailty index over time. CONCLUSIONS People with diabetes or higher HbA 1c levels at baseline had a higher frailty level throughout later life. Nonfrail participants with diabetes or higher HbA 1c also experienced more rapid deterioration of frailty level with aging. This observation could reflect a role of diabetes complications in frailty trajectories or earlier shared determinants that contribute to diabetes and frailty risk in later life. Life expectancy is increasing worldwide. However, the aging process is heterogeneous with a large interindividual variability in health status and disability (1). This heterogeneity in aging can also affect people with diabetes, who are also living longer than before. Although the age-specific prevalence of diabetic complications is lower now than in the past, the cumulative lifetime prevalence of complications in older adults with diabetes and the co-occurrence of multiple medical conditions are higher (2).

show abstract

Section: Discussioncontrasting

confidence: 67%

Prospective Association Among Diabetes Diagnosis, HbA1c, Glycemia, and Frailty Trajectories in an Elderly Population

et al. 2019

View full text Add to dashboard Cite

show abstract

“… Mobile telemonitoring offers benefits for treating diabetes. Jensen et al (2017) 60 Denmark Understanding the risk factors of adherence reduction related to the different phases of treatment. Factors that can decrease adherence are different from the treatment phases.…”

Section: Resultsmentioning

confidence: 99%

<p>Compliance, adherence, concordance, empowerment, and self-management: five words to manifest a relational maladjustment in diabetes</p>

Salvatore¹,

Frisone²,

Merlo³

et al. 2019

JMDH

View full text Add to dashboard Cite

Background: The pathological reality of diabetes and the incidents in following the prescribed therapies have been considered and are still a serious and relevant problem in the health sector. Objective: This review aims at highlighting the importance of clinical psychological phenomena that underlie the notion of therapies. Methods: The review was conducted through search engines such as PubMed, Medline, Web of Science and Google Scholar. The articles related to compliance, adherence, concordance, empowerment and the self-management of diabetes were included, in order to highlight the possible similarities and differences that these terms bring with them in them management of diabetes. Results: Starting from 252 initial publications, 101 articles were selected that highlighted the practical implications that each term has compared to the others. Conclusion: The review can represent a bridge between the medical approach and clinical psychology, in which integration can suggest paths aiming at improving patients’ existential conditions and adaptation.

show abstract

“…Consequently, emergence and worsening of complications result in significant impact on physical, emotional and social aspects of life. Moreover, nonadherence to antidiabetic agents increases the risk for hospitalisation and all-cause mortality (Jensen, Jørgensen, Hansen, Aagaard, & Carstensen, 2017).…”

Section: Introductionmentioning

confidence: 99%

Psychosocial determinants of adherence to oral antidiabetic medication among people with type 2 diabetes

Jannuzzi

Cornélio

São‐João

et al. 2020

Journal of Clinical Nursing

View full text Add to dashboard Cite

Aims and objectives The aim of this study was to identify the psychosocial determinants of adherence to oral antidiabetic medication, according to the Theory of Planned Behaviour (TPB). Background Appropriate adherence to oral antidiabetic medication contributes to long‐term glycaemic control. However, glycaemic control is often poor in people with type 2 diabetes, mainly due to the poor adherence to oral antidiabetic agents. Design Prospective study with 2 waves of data collection, based on STROBE checklist was conducted. One hundred and fifty‐seven adults with type 2 diabetes, in chronic use of oral antidiabetic agents, composed the sample. At baseline, self‐reported measures of medication adherence (proportion and global evaluation of adherence) and of metabolic control (glycated haemoglobin) of diabetes were obtained. Methods The TPB main constructs (attitude, subjective norm and perceived control) and related beliefs were measured. Adherence and metabolic control measurements were obtained in a two‐month follow‐up (n = 157). Results Attitude and subjective norm, together, explained 30% of the variability in intention; their underlying belief‐based measures (behavioural and normative beliefs) explained 28% of the variability in intention. In addition, intention predicted behaviour at follow‐up. However, when added to the prediction model, past behaviour was the only explanatory factor of adherence behaviour. Conclusion Adherence behaviour to oral antidiabetic medication was predicted by intention, which, in turn, was determined by attitude and subjective norm. In order to promote adherence to oral antidiabetic agents, health professionals should include motivational strategies as well as strategies targeted to attitude and subjective norm when designing interventions. Relevance to clinical practice The nonadherence to antidiabetic medication contributes to lack of control of diabetes and ensuing complications. The comprehension of the factors explaining the variability in medication adherence can inform the design of theory‐based interventions aimed at promoting this behaviour.

show abstract

Long-term patterns of adherence to medication therapy among patients with type 2 diabetes mellitus in Denmark: The importance of initiation

Cited by 23 publications

References 37 publications

Prospective Association Among Diabetes Diagnosis, HbA1c, Glycemia, and Frailty Trajectories in an Elderly Population

Prospective Association Among Diabetes Diagnosis, HbA1c, Glycemia, and Frailty Trajectories in an Elderly Population

<p>Compliance, adherence, concordance, empowerment, and self-management: five words to manifest a relational maladjustment in diabetes</p>

Psychosocial determinants of adherence to oral antidiabetic medication among people with type 2 diabetes

Contact Info

Product

Resources

About