Long-term Patient-Reported Outcomes in Older Breast Cancer Survivors: A Population-Based Survey Study

Swanick, Cameron W.; Lei, Xiudong; Xu, Ying; Shen, Yu; Goodwin, Nathan; Smith, Grace L.; Giordano, Sharon H.; Hunt, Kelly K.; Jagsi, Reshma; Shaitelman, Simona F.; Peterson, Susan K.; Smith, Benjamin D.

doi:10.1016/j.ijrobp.2017.11.047

Cited by 25 publications

(27 citation statements)

References 38 publications

(55 reference statements)

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“…A recent study found that among older early-stage breast cancer patients who received adjuvant radiotherapy, brachytherapy APBI patients had the most favorable CanSORT, BREAST-Q, and physical well-being scores, despite having statistically significantly increased risks of adverse radiation effects, ipsilateral breast recurrence, and subsequent mastectomy compared to patients who underwent whole-breast irradiation. 16…”

Section: Discussionmentioning

confidence: 99%

Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation With Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy

Stecklein

Shaitelman

Babiera

et al. 2019

Practical Radiation Oncology

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Brachytherapy APBI is associated with higher rates of grade 1 fibrosis and seroma than 3-dimensional CRT but lower rates of grade 1 edema and grade 2 to 3 pain than 3-dimensional CRT. Rates of radiation oncologist-reported fair or poor cosmetic outcomes are higher with brachytherapy. We identified dosimetric parameters that predict reduced risk of adverse cosmetic outcome after brachytherapy-based APBI. Ipsilateral breast recurrence was equivalent for brachytherapy and 3-dimensional CRT.

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Section: Discussionmentioning

confidence: 99%

Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation With Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy

Stecklein

Shaitelman

Babiera

et al. 2019

Practical Radiation Oncology

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“…Interestingly, women who had completed the surveys were younger than those who did not. Another study of older breast cancer patients, with a median age of 72 at diagnosis, had a survey response rate of only 30%, so it may be that older women are less likely to complete questionnaires.…”

Section: Discussionmentioning

confidence: 99%

Patient‐reported outcomes of breast reconstruction in older women: Audit of a large metropolitan public/private practice in Sydney, Australia

Flitcroft

Brennan

et al. 2018

Psycho-Oncology

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“…Mostly, the data is used for assessing interventions, quality indicators and for following up the quality of care [30]. The EQ-5D-3L has also been used in previous studies on cancer survivors and late toxicity effects after cancer treatment [31][32][33][34]. In the study by Yu et al on breast cancer survivors in Korea, there was no difference in the EQ-5D-3L index in general between survivors and an agematched control group 5 years after surgery; however, in the categories of pain/discomfort and anxiety/depression, the survivors still scored worse than the controls [34].…”

Section: Introductionmentioning

confidence: 99%

Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency

et al. 2021

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Purpose Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals’ health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC). Methods Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015 at the Reproductive Medicine Centre at Skåne University Hospital in Malmö, Sweden. All participants, except for two HCs, answered an EQ-5D-3L questionnaire for measuring health state including a visual analogue scale (VAS) for estimating well-being. Results There were 22 CCS with POI, none of the HC had POI. The mean health state differed among groups (unadjusted: P = 0.002; adjusted: P = 0.007). A difference in mean experienced well-being among groups was noted (unadjusted: P = 0.003; adjusted: P = 0.012). Lowest well-being was found in the CCS group with POI (P = 0.024). Conclusions Female CCS have a significantly decreased health state and well-being. Female CCS with POI additionally have the lowest self-estimated well-being. Implications for Cancer Survivors Female CCS with POI should be identified early in order to give them adequate information and support.

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Long-term Patient-Reported Outcomes in Older Breast Cancer Survivors: A Population-Based Survey Study

Abstract: In this nationally diverse cohort, less irradiation and less surgery were associated with better long-term quality-of-life outcomes. However, patient regret regarding surgery and radiation therapy was similar across all groups.

Cited by 25 publications

References 38 publications

Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation With Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy

Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation With Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy

Patient‐reported outcomes of breast reconstruction in older women: Audit of a large metropolitan public/private practice in Sydney, Australia

Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency

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