Long term palliation of advanced tracheobronchial tumors by HDR brachytherapy in the interdisciplinary concept

Bodegom, Peter C. Van; Becker, Heinrich D.; Fritz, P.; Schraube, P.; Drings, P.; Wannenmacher, M.; Vogt-Moykops, I.

doi:10.1016/0169-5002(91)91713-l

Cited by 3 publications

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“…However, no benefit in either local control or survival was demonstrated using this approach as compared with external radiotherapy alone. In a small study published in 1992 by VAN BODEGON et al [12], selected patients were treated with external beam radiotherapy to 46 Gy and three 6 Gy courses of endobronchial brachytherapy delivered at 10 mm from the source. Median survival had not been reached at the time of publication, suggesting the potential benefit of endobronchial boosting in terms of local control.…”

Section: Endobronchial Brachytherapy With Curative Intentmentioning

confidence: 99%

High dose rate endobronchial brachytherapy: results and complications in 189 patients

Taulelle¹,

Chauvet²,

Vincent³

et al. 1998

Eur Respir J

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The purpose of this study was to determine the benefit of high dose rate endobronchial brachytherapy in the treatment of obstructive lung cancer. Between September 1990 and March 1995, 189 patients with bronchogenic carcinoma were treated with high dose rate endobronchial brachytherapy. Most patients (69.3%) had received prior treatment and presented with symptomatic bronchial obstruction due to either recurrent or residual endobronchial disease. A small group (12%) was medically unfit for either surgical resection or thoracic radiotherapy and benefited from endobronchial brachytherapy alone for small endobronchial tumours. The remainder of the patients had not been treated previously and endobronchial brachytherapy was performed for life-threatening symptoms requiring emergency obstruction relief before other therapy. Treatment was performed weekly and consisted of three to four 8 to 10 Gy fractions at a radius of 10 mm from the centre of the source. Major symptomatic relief was obtained for haemoptysis (74%), dyspnoea (54%), and cough (54%). Complete endoscopic response was observed in 54% of cases. Median survival was 7 months for the entire group. For small, strictly endobronchial tumours, complete response rate was 96%, median survival 17 months, and 30 month survival 46%, with a plateau starting at 18 months. Grade 3 to 4 toxicities occurred at a rate of 17% and included massive haemoptysis (n=13), bronchial stenosis (n=12), soft tissue necrosis (n=8), and bronchial fistula (n=3). By univariate analysis, no factor was found to be predictive of late pulmonary toxicity. The present study confirms the usefulness of endobronchial brachytherapy in alleviating symptoms caused by endobronchial recurrence of bronchogenic carcinoma. In addition, this therapy can be tried with curative intent in patients who present with small endobronchial tumours and are not candidates for other forms of therapy.

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Section: Endobronchial Brachytherapy With Curative Intentmentioning

confidence: 99%