Long-term ozone exposure is negatively associated with estimated glomerular filtration rate in Chinese middle-aged and elderly adults

Zhang, Yiqin; Tang, Chen; Liu, Yuwen; Jiang, Hanxiang; Lu, Jiaosheng; Lu, Zhonghua; Xu, Liping; Zhang, Siyu; Zhou, Lina; Ye, Jing; Xuan, Xianfa; Wu, Ting; Cao, Xia; Zhao, Benhua; Lin, Liangquan; Wang, Yuxin; Zhang, Jie

doi:10.1016/j.chemosphere.2023.140040

Cited by 1 publication

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“…However, study on the effects of O 3 on the renal outcome and mortality in chronic kidney disease (CKD) is lacking. While it has been observed that there is a correlation between long-term exposure to O 3 and the prevalence of CKD, as well as an inverse correlation with eGFR [ 13 , 14 ], some experimental studies have reported that O 3 may play a role in the treatment of kidney disease [ 15 ]. Therefore, further research is needed to determine whether long-term exposure to O 3 affects the long-term prognosis of CKD.…”

Section: Introductionmentioning

confidence: 99%

Long-term ozone exposure and mortality in patients with chronic kidney disease: a large cohort study

Kim,

Huh,

et al. 2024

BMC Nephrol

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Background Epidemiologic studies on the effects of long-term exposure to ozone (O3) have shown inconclusive results. It is unclear whether to O3 has an effect on chronic kidney disease (CKD). We investigated the effects of O3 on mortality and renal outcome in CKD. Methods We included 61,073 participants and applied Cox proportional hazards models to examine the effects of ozone on the risk of end-stage renal disease (ESRD) and mortality in a two-pollutants model adjusted for socioeconomic status. We calculated the concentration of ozone exposure one year before enrollment and used inverse distance weighting (IDW) for interpolation, where the exposure was evenly distributed. Results In the single pollutant model, O3 was significantly associated with an increased risk of ESRD and all-cause mortality. Based on the O3 concentration from IDW interpolation, this moving O3 average was significantly associated with an increased risk of ESRD and all-cause mortality. In a two-pollutants model, even after we adjusted for other measured pollutants, nitrogen dioxide did not attenuate the result for O3. The hazard ratio (HR) value for the district-level assessment is 1.025 with a 95% confidence interval (CI) of 1.014–1.035, while for the point-level assessment, the HR value is 1.04 with a 95% CI of 1.035–1.045. The impact of ozone on ESRD, hazard ratio (HR) values are, 1.049(95%CI: 1.044–1.054) at the district unit and 1.04 (95%CI: 1.031–1.05) at the individual address of the exposure assessment. The ozone hazard ratio for all-cause mortality was 1.012 (95% confidence interval: 1.008–1.017) for administrative districts and 1.04 (95% confidence interval: 1.031–1.05) for individual addresses. Conclusions This study suggests that long-term ambient O3 increases the risk of ESRD and mortality in CKD. The strategy to decrease O3 emissions will substantially benefit health and the environment.

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Section: Introductionmentioning

confidence: 99%