Long-Term Oxygen Therapy

Tarpy, Stephen P.; Celli, Bartolomé R.

doi:10.1056/nejm199509143331107

Cited by 186 publications

(72 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The individuals studied were referred to the study centre to undergo assessment for home oxygen therapy. Some authors have proposed [11][12][13] that these patients can be evaluated by pulse oximetry alone, without the need for arterial blood gas analysis. Nevertheless, 59% of the patients in the present study had high Pa,CO 2 levels, which we have shown can lead to overestimation of Sa,O 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Currently, there are no studies that determine [16], a frequent situation in this population [11][12][13]. The main aim of the present study was to determine whether altered blood CO 2 levels can change the existing relationship between Sa,O 2 and Sp,O 2 .…”

mentioning

confidence: 90%

“…Very few studies have examined the agreement between Sa,O 2 and Sp,O 2 in the setting of outpatient monitoring [8][9][10], an area in which this information can be highly relevant. With the development of long-term home oxygen therapy and home mechanical ventilation, clinicians attend an increasingly greater number of patients with end-stage lung disease in whom the decisions regarding these and other therapies are often based on pulse oximetry findings [11][12][13][14].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Accuracy and reliability of pulse oximetry at different arterial carbon dioxide pressure levels

Muñoz¹,

Sampol²,

Ríos³

et al. 2008

European Respiratory Journal

View full text Add to dashboard Cite

The present study aimed to assess whether arterial carbon dioxide pressure (Pa,CO 2 ) has an impact on agreement between oxygen saturation measured with pulse oximetry (Sp,O 2 ) or arterial blood gas co-oximetry (Sa,O 2 ).Sa,O 2 and Sp,O 2 determinations were obtained simultaneously from 846 patients under assessment for long-term home oxygen therapy in a specialised outpatient clinic. Both measurements were taken with patients seated and breathing room air.Agreement between Sa,O 2 and Sp,O 2 results was analysed by the Bland-Altman method and the Lin concordance coefficient. In addition, potential interactions of arterial oxygen tension (Pa,O 2 ) or Pa,CO 2 on agreement were analysed by adjusted multivariate analysis.Upon comparison of Sa,O 2 and Sp,O 2 results, the Bland-Altman technique yielded a bias (95% confidence interval (CI)) of -1.24 (-6.86-4.38) and -1.32 (-7.78-5.15) when Pa,CO 2 .48 mmHg (6.39 kPa) or Pa,O 2 ,54 mmHg (7.20 kPa), respectively. Estimate by Lin's coefficient (95% CI) in these cases was 0.88 (0.85-0.90) and 0.81 (0.77-0.85). Adjusted multivariate analysis, performed to assess the impact of pH, Pa,O 2 , Pa,CO 2 and bicarbonate on bias, showed that Pa,O 2 , Pa,CO 2 and their interaction terms were the most important predictors of the bias (standardised estimates of -0.54, -0.94, and 0.85, respectively). The effect of pH, although statistically significant, was small, and bicarbonate had no significant effect.Arterial carbon dioxide pressure status can contribute to impaired agreement between arterial oxygen saturation and arterial oxygen saturation measured with pulse oximetry, particularly in patients with hypercapnia.

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 90%

mentioning

confidence: 99%

See 1 more Smart Citation

Accuracy and reliability of pulse oximetry at different arterial carbon dioxide pressure levels

Muñoz¹,

Sampol²,

Ríos³

et al. 2008

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…The primary goal of LTOT is to increase the baseline arterial oxygen tension (Pa,O 2 ) to o7.9 kPa (o60 mmHg) at rest. LTOT administered continuously (.15 h?day -1 ) to hypoxaemic COPD patients increases survival [41,42]. It is generally introduced in severe COPD and implemented according to international recommendations [43,44].…”

Section: Transcutaneous Neuromuscular Electrical Stimulationmentioning

confidence: 99%

Nonpharmacological treatment and relief of symptoms in COPD

Clini

Ambrosino²

2008

European Respiratory Journal

View full text Add to dashboard Cite

Evidence-based guidelines for chronic obstructive pulmonary disease (COPD) have recently been developed.Nonpharmacological treatments have evolved rapidly as an essential part of COPD therapy. They are especially important as complementary interventions in severe or very severe disease, when there is loss in function, a reduction in quality of life and when psychological impairments further complicate the disease.The present article discusses the most used nonpharmacological treatments for severe COPD patients (rehabilitation, long-term oxygen therapy, surgery, noninvasive positive pressure ventilation and supportive nutrition) and their evidence-based usefulness in promoting strategies that relieve symptoms.All of these interventions are used during end-stage disease, to promote self-efficacy, relieve symptoms and prevent further deterioration. These therapeutic options support physicians and allied professionals in improving symptom management for their patients.

show abstract

“…Long-term oxygen therapy was also shown to reduce mortality and improve quality of life in patients with severe COPD and chronic hypoxemia (partial pressure of arterial oxygen <55 mm Hg) [61] . The presence of COPD affects the treatment of HF, in as much as COPD is still viewed as a contraindication to β-blockade.…”

Section: Chronic Obstructive Pulmonary Disease and Heart Failurementioning

confidence: 99%

Köpeklerde Geriatrik Kardiyoloji - Bölüm 2: Geriatrik Köpeklerde Kalp Yetmezliği Tedavisinde Zorluklar: İlaç Reaksiyonları ve Komorbitler

Turgut¹,

Suleymanoglu²,

Ertan³

et al. 2017

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

How to Cite This Article AbstractIn geriatric dogs, aging-specific changes in cardiovascular physiology, drug metabolism, drug pharmacokinetics and drug tolerance contribute to adverse drug reactions (ADRs). Comorbidities can also cause polypharmacy and thus drug-drug interactions. Adverse drug reactions for ACE inhibitors, β-blockers, furosemide, aldosterone antagonists and digoxin are common. Geriatric cardiology epitomizes the principle that cardiovascular disease is only 1 component of a larger, multidimensional disease state with concomitant geriatric syndromes. Comorbidities (cardiorenal syndrome, hypertension, diabetes mellitus, atherosclerotic disease, metabolic syndrome, obesity, chronic obstructive pulmonary disease and frailty and cognitive dysfunction) are common, aggravate HF, complicate therapy and increase the total heart failure burden.

show abstract

Long-Term Oxygen Therapy

Cited by 186 publications

References 40 publications

Accuracy and reliability of pulse oximetry at different arterial carbon dioxide pressure levels

Accuracy and reliability of pulse oximetry at different arterial carbon dioxide pressure levels

Nonpharmacological treatment and relief of symptoms in COPD

Köpeklerde Geriatrik Kardiyoloji - Bölüm 2: Geriatrik Köpeklerde Kalp Yetmezliği Tedavisinde Zorluklar: İlaç Reaksiyonları ve Komorbitler

Contact Info

Product

Resources

About