Long Term Ovariectomy-Induced Osteoporosis is Associated with High Stearoyl-CoA Desaturase Indexes in Rat Femur

During, Alexandrine; Coutel, Xavier; Bertheaume, Nicolas; Penel, Guillaume; Olejnik, Cécile

doi:10.1007/s00223-019-00637-7

Cited by 11 publications

(20 citation statements)

References 34 publications

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“…It has been shown that LPCs induce the production of reactive oxygen species and promote oxidative stress damage in tissues [ 32 , 33 ]. This indicates that the increase in oxidative stress might be associated with an increase in bone loss and thus an exacerbation of OP [ 34 ]. Overall, our findings of increased glycerophospholipids (PC, PE, and LPC) are due to the process of OP progression.…”

Section: Discussionmentioning

confidence: 99%

Lipidomics Profiling of Patients with Low Bone Mineral Density (LBMD)

Aleidi

Al-Ansari

Alnehmi

et al. 2022

IJMS

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The relationship between lipid metabolism and bone mineral density (BMD) is still not fully elucidated. Despite the presence of investigations using osteoporotic animal models, clinical studies in humans are limited. In this work, untargeted lipidomics profiling using liquid chromatography-mass spectrometry (LC-MS) analysis of human serum samples was performed to identify the lipidomics profile associated with low bone mineral density (LBMD), with a subsequent examination of potential biomarkers related to OP risk prediction or progression. A total of 69 participants were recruited for this cohort study, including the osteoporotic group (OP, n = 25), osteopenia group (ON, n = 22), and control (Ctrl, n = 22). The LBMD group included OP and ON patients. The lipidomics effect of confounding factors such as age, gender, lipid profile, body mass index (BMD), chronic diseases, and medications was excluded from the dataset. The results showed a clear group separation and clustering between LBMD and Ctrl (Q2 = 0.944, R2 = 0.991), indicating a significant difference in the lipids profile. In addition, 322 putatively identified lipid molecules were dysregulated, with 163 up- and 159 down-regulated in LBMD, compared with the Ctrl. The most significantly dysregulated subclasses were phosphatidylcholines (PC) (n = 81, 25.16% of all dysregulated lipids 322), followed by triacylglycerol (TG) (n = 65, 20.19%), and then phosphatidylethanolamine (PE) (n = 40, 12.42%). In addition, groups of glycerophospholipids, including LPC (7.45%), LPE (5.59%), and PI (2.48%) were also dysregulated as of LBMD. These findings provide insights into the lipidomics alteration involved in bone remodeling and LBMD. and may drive the development of therapeutic targets and nutritional strategies for OP management.

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Section: Discussionmentioning

confidence: 99%

Lipidomics Profiling of Patients with Low Bone Mineral Density (LBMD)

Aleidi

Al-Ansari

Alnehmi

et al. 2022

IJMS

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“…The results indicated FADS may be a potential therapeutic target as FADS expression and mutations were associated with liver fat. SCD, a FADS member gene, is an endoplasmic reticulum enzyme that catalyses the biosynthesis of MUFAs from SFAs and is the critical gene responsible for the synthesis of TG, phospholipids, and cholesterol esters (Marklund et al 2018;During et al 2020). SCD plays an important role in TG accumulation, as overfeeding markedly increased the mRNA expression of SCD in the liver of Sichuan White geese and Landes geese, and the mRNA abundance of SCD in the liver had significant positive correlations with TG content in liver lipids and in the levels of plasma insulin and VLDL levels in Sichuan white geese (Zhang et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Comparison of performance, fatty acid composition, enzymes and gene expression between overfed Xupu geese with large and small liver

Liu

Cheng

et al. 2021

Italian Journal of Animal Science

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The aim of our study was to compare overfeeding performance, fatty acid composition, enzymes activity and gene expression between overfed Xupu geese with large and small liver. A total of sixty 80 d male Xupu geese were overfed by the same feed intake under the same conditions. The liver weight exhibited normal distribution. Based on the weight of liver, samples were divided into large liver (LL) and small liver (SL) Xupu geese. After overfeeding for 28 d: compared with the SL-Xupu geese, liver weight and liver-to-body weight ratio increased (p < .05), while abdominal fat weight and feed-to-liver weight ratio decreased (p < .05); the level of palmitic acid and methyltetracosanoate acid decreased (p < .05), and the level of oleic acid, linoleic acid, arachidonic acid, and docosahexaenoic acid increased (p < .05) in liver of LL-Xupu geese. Compared with the SL-Xupu geese, LL-Xupu geese had a higher plasma concentration of TG (triglyceride) (p < .05), and had a lower plasma concentration of VLDL-C (very low density lipoprotein cholesterol) (p < .05); and had a higher CHE (cholinesterase), LPS (lipase), LPL (lipoproteinlipase) activities (p < .05) in the liver. The mRNA expression of FABP4 (adipocyte fatty acid binding protein), SCD (stearoyl-CoA desaturase), FADS (fatty acid dehydrogenase), ELOVL1 (elongase of long-chain fatty acid 1), ACAT2 (acyl-Co A: cholesterol acyltransferase 2), and FASN (fatty acid synthase) (p < .05) were significantly upregulated in LL-Xupu geese than in SL-Xupu geese. The results showed that the level of unsaturated fatty acid in liver of LL-Xupu geese was higher than that of SL-Xupu geese, which may be closely related to enzymes and genes expression related to lipid metabolism. HIGHLIGHTSThe content of unsaturated fatty acids in liver of LL-Xupu geese were significantly higher than in SL-Xupu geese. The mRNA expression of FABP4, SCD, FADS, ELOVL1, ACAT2, and FASN were significantly upregulated in LL-Xupu geese than in SL-Xupu geese. The level of unsaturated fatty acid in liver of LL-Xupu geese was higher than that of SL-Xupu geese, which may be closely related to enzymes and genes expression related to lipid metabolism.

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“…All of these revealed the excessive accumulation of SM properly could be tightly associated with bone defects. On the other side, although there is an increase of SM in bone marrow while there is a significant reduction of SM in the mineralized tissue part of OVX rat femurs ( During et al, 2020 ), which suggested that excessive catabolism of SM could be associated with bone resorption. But more investigations will be needed regarding the potential role of SM in bone and the underlying mechanism.…”

Section: Sphingomyelin and Bone Remodelingmentioning

confidence: 99%

The Role of Sphingolipid Metabolism in Bone Remodeling

Tang

Liao

Tian

2021

Front. Cell Dev. Biol.

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Emerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obtain new insights into the role sphingolipid played on skeletal remodeling. This review summarizes studies or understandings of the crosstalk between sphingomyelin, ceramide, and sphingosine-1-phosphate (S1P) of sphingolipids family and the cells, especially osteoblasts and osteoclasts of the bone through which bone is remodeled during life constantly. This review also shows agonists and antagonists of S1P as possible therapeutic options and opportunities on bone diseases.

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Long Term Ovariectomy-Induced Osteoporosis is Associated with High Stearoyl-CoA Desaturase Indexes in Rat Femur

Cited by 11 publications

References 34 publications

Lipidomics Profiling of Patients with Low Bone Mineral Density (LBMD)

Lipidomics Profiling of Patients with Low Bone Mineral Density (LBMD)

Comparison of performance, fatty acid composition, enzymes and gene expression between overfed Xupu geese with large and small liver

The Role of Sphingolipid Metabolism in Bone Remodeling

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