Long-term outcomes of two ablation techniques for treatment of radio-recurrent prostate cancer

Nair, Shiva M.; Peters, Max; Kurver, P.H.J.; Lavi, Arnon; Verhoeff, J.; Zyp, Jochem R.N. van der Voort van; Son, Marieke van; Chin, Joseph L.

doi:10.1038/s41391-020-00265-5

Cited by 6 publications

(12 citation statements)

References 16 publications

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“…Most cryotherapy patients did eventually require ADT with 90% starting by 20 years with a mean time to ADT of 11 years. In other studies, ADT initiation ranged from 30% at 5 years to 51% at 10 years [12,13 ▪ ].…”

Section: Oncologic Outcomesmentioning

confidence: 83%

“…Metastatic progression occurred in seven patients (19%) during follow-up. Nair et al reported on 187 patients who underwent salvage cryotherapy with a 10-year Kaplan–Meier estimated BCR rate of 55.8% [13 ▪ ]. The 10-year estimates of metastasis and cancer-specific mortality rates were 21.2% and 15.8%, respectively.…”

Section: Oncologic Outcomesmentioning

confidence: 99%

“…Several recent studies have also reported on oncologic outcomes of salvage HIFU (Table 2). Nair et al reported a 10-year Kaplan–Meier estimated BCR rate of 71.3% [13 ▪ ]. The 10-year estimates of metastasis and prostate cancer-specific mortality rate were 23.8% and 15.2%, respectively.…”

Section: Oncologic Outcomesmentioning

confidence: 99%

“…Reporting of oncologic outcomes varied by study, but the most common metric used was BCR as defined by the Phoenix definition [10 ▪ ,11 ▪ ,12,13 ▪ ,14]. Two recent meta-analyses have reported on salvage local therapies after radiation [3 ▪▪ ,15 ▪▪ ].…”

Section: Oncologic Outcomesmentioning

confidence: 99%

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Salvage ablation for locally recurrent prostate cancer

Lomas¹,

Woodrum

Mynderse³

2021

Current Opinion in Urology

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Purpose of reviewThis review aims to summarize the latest evidence for the use of salvage ablation of localized prostate cancer recurrences after primary therapy radiotherapy or prostatectomy.Recent findingsSavage ablation represents a treatment option in select patients with localized recurrences following primary therapy of prostate cancer. Following radiotherapy, salvage cryotherapy and high-intensity focused ultrasound (HIFU) demonstrate encouraging oncologic outcomes. Biochemical recurrence-free survival ranged from 71% at 2 years to 44.2% at 10 years for cryotherapy and from 51% at 5 years to 28.7% at 10 years for HIFU. Rates of adverse effects appear to be more favorable with ablation compared to salvage surgery. Focal salvage ablation may offer a further balance between oncologic control and adverse effects. Following radical prostatectomy, recent data on the use of salvage ablation of local recurrences are less robust with only a few small studies published in the last 2 years.SummarySalvage ablation is an option for localized disease recurrences following primary treatment. Its role is most established for postradiation recurrence. It can also be utilized in postprostatectomy recurrence, although published data is more limited. Future studies are needed to further explore the role of ablation in both cohorts.

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Section: Oncologic Outcomesmentioning

confidence: 83%

Section: Oncologic Outcomesmentioning

confidence: 99%

Section: Oncologic Outcomesmentioning

confidence: 99%

Section: Oncologic Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Salvage ablation for locally recurrent prostate cancer

Lomas¹,

Woodrum

Mynderse³

2021

Current Opinion in Urology

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“…Furthermore, this group has previously reported that salvage cryotherapy is associated with a 50% chance of avoiding ADT at 10 years of followup. 5 Risks of serious complications, such as rectourethral fistula (3.3%) and severe incontinence (6.7%) 6 are acceptable and compare favorably against salvage radical prostatectomy, where the risk of incontinence is 20-78% and the risk of rectal injury is 0-9%. 7 Some may desire a prospective, randomized trial prior to widespread clinical use of salvage ablative techniques for radio-recurrent prostate cancer.…”

mentioning

confidence: 99%

Local salvage ablation therapy after radiation therapy for prostate cancer — are we there yet?

Bhindi¹

2021

CUAJ

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Salvage Cryoablation for Recurrent Prostate Cancer Following Radiation—A Comprehensive Review

Lee,

Thakker,

Pineault

et al. 2024

Cancers

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The treatment options for prostate cancer typically entail active surveillance, surgery, radiation, or a combination of the above. Disease recurrence remains a concern, with a wide range of recurrence rates having been reported in the literature. In the setting of recurrence, the salvage treatment options include salvage prostatectomy, salvage high-intensity focused ultrasound (HIFU), stereotactic body radiotherapy (SBRT), salvage brachytherapy, and salvage cryoablation. In this review, we analyze the currently available data related to salvage cryoablation for recurrent prostate cancer following radiation.

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Long-term outcomes of two ablation techniques for treatment of radio-recurrent prostate cancer

Cited by 6 publications

References 16 publications

Salvage ablation for locally recurrent prostate cancer

Salvage ablation for locally recurrent prostate cancer

Local salvage ablation therapy after radiation therapy for prostate cancer — are we there yet?

Salvage Cryoablation for Recurrent Prostate Cancer Following Radiation—A Comprehensive Review

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