Long-term Outcomes of Surgeries for Retinal Detachment Secondary to Parasitic or Viral Infectious Retinitis

Abstract

This study sought to compare the long-term outcomes of surgeries for retinal detachment (RD) secondary to viral or parasitic infectious retinitis.Methods: 47 eyes that received pars plana vitrectomy with or without scleral buckling due to RD secondary to polymerase chain reaction-proven viral (Cytomegalovirus, Varicella zoster virus, and Herpes zoster virus) or parasitic (toxoplasma and toxocara) retinitis from October 1 st , 2006 to June 30 th , 2023 in a single medical center were retrospectively enrolled.Results: Mean follow-up period was 59.03 ± 55.24 months in viral retinitis and 34.80 ± 33.78 months in parasitic retinitis after primary reattachment surgery. During follow-up, 9 eyes (24.3%) with viral retinitis and 5 eyes (50.0%) with parasitic retinitis developed retinal redetachment. Visual acuity success at final follow-up was achieved in 19 eyes (51.4%) with viral retinitis and 6 eyes (60.0%) with parasitic retinitis (p = 0.64). The incidence of retinal redetachment during the first postoperative year was significantly higher in parasitic retinitis compared with viral retinitis (crude incidence 0.21 vs 0.85 in viral and parasitic retinitis, respectively; p = 0.02). Hazard ratio analysis adjusted for age and sex showed 4.58-fold (95% confidence interval 1.22-17.27, p = 0.03) increased risk of retinal redetachment in parasitic retinitis compared with viral retinitis during the first postoperative year. Tamponade with silicone oil and preoperative diagnostic vitrectomy were associated with significantly decreased risk of retinal redetachment in patients with parasitic retinitis. Conclusions:Compared with RD secondary to viral retinitis, RD secondary to parasitic retinitis showed higher incidence of retinal redetachment during the first postoperative year. Tamponade with silicone oil and preoperative diagnostic vitrectomy were associated with significantly decreased risk of retinal redetachment in patients with parasitic retinitis.