Long-term outcomes of school-based treatment for control of urinary schistosomiasis: a review of experience in Coast Province, Kenya

King, Charles H.

doi:10.1590/s0074-02762006000900047

Cited by 33 publications

(34 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is pertinent to state however, that since the adoption of the WHA resolution, great progress has been made in a number of sub-Saharan African countries in the control of STH infections and schistosomiasis via mass chemotherapy among school children Adams et al, 2004;Mafe et al, 2005;King, 2006;Kihara et al, 2007;Adugna et al, 2007;Midzi et al, 2008). In many parts of sub-Saharan Africa there is currently a growing awareness of the public health significance of these helminth infections which previously were grossly neglected, and concerted advocacy for their control has resulted in increased political will and financial means to combat them (Keiser & Utzinger, 2008).…”

Section: Discussionmentioning

confidence: 99%

Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: Efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001

Uneke

2010

Tanzania J Hlth Res

View full text Add to dashboard Cite

Soil transmitted helminth infections (STH) and schistosomiasis constitute major public health challenges among school-age children in sub-Saharan Africa. This review assessed the efficacy of chemotherapeutic intervention in line with the World Health Assembly (WHA) resolution since the passage in 2001. Using the Medline Entrez-Pubmed search, relevant publications were identified via combinations of key words such as helminth infection, school children, chemotherapy, Africa. Albendazole, mebendazole, and praziquantel were the antihelminthic drugs most commonly evaluated. Cure rates >80% and egg reduction rates >90% were recorded in most cases of schistosomiasis using praziquantel. Albendazole was very effective against A. lumbricoides and hookworm infections with majority of the studies recording cure rates >75%, but the efficacy of the drug was poor against T. trichiura. To ensure the realization of the WHA resolution, there is need for regular treatment of school children, development of alternative antihelminthic drugs and vaccines, environmental control measures and health education. ______________________________________________________________________________________

show abstract

Section: Discussionmentioning

confidence: 99%

Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: Efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001

Uneke

2010

Tanzania J Hlth Res

View full text Add to dashboard Cite

show abstract

“…These concerns, together with a need to better understand a number of fundamental clinical and epidemiological aspects of human helminth infections as well as their interactions with geographically overlapping coinfections (e.g., malaria and HIV/AIDS) have created an urgency for stepped up clinical research activities as they relate to largescale helminth control. Such activities have focused around three major areas: first, a reexamination of the health impact of human helminthic infections, with particular interest in the effects of mono- and polyparasitism on childhood growth and development as well as their effects on pregnancy and birth outcomes (63,(136)(137)(138)(139)(140); second, large-scale monitoring and evaluation of MDA and integrated control, along with operational research with goals to improve the access of populations to anthelminthic drugs and to monitor for possible drug resistance (141)(142)(143)(144)(145); and third, the development of new tools to control helminth infections, that is, drugs, diagnostics, and vaccines (19,146).…”

Section: Global Control Of Helminthiases and Clinical Research Imperamentioning

confidence: 99%

Helminth infections: the great neglected tropical diseases

et al. 2008

View full text Add to dashboard Cite

Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.

show abstract

“…In the present study, we present our findings from four villages in coastal Kenya known to be coendemic for Schistosoma haematobium, STH, Plasmodium falciparum, and Wuchereria bancrofti. 1,[20][21][22][23][24] …”

Section: Introductionmentioning

confidence: 99%

Impact of Polyparasitic Infections on Anemia and Undernutrition among Kenyan Children Living in a Schistosoma haematobium-Endemic Area

Bustinduy

Parraga

Thomas

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. We measured prevalence of Schistosoma haematobium, Wuchereria bancrofti, Plasmodium falciparum, hookworm, and other geohelminths among school-aged children in four endemic villages in Kwale County, Kenya and explored the relationship between multiparasite burden, undernutrition, and anemia. In 2009-2010 surveys, cross-sectional data were obtained for 2,030 children 5-18 years old. Infections were most prevalent for S. haematobium (25-62%), hookworm (11-28%), and falciparum malaria (8-24%). Over one-half of children were anemic, with high rates of acute and chronic malnutrition. Associations with infection status showed significant age and sex differences. For boys, young age, low socioeconomic standing (SES), S. haematobium, and/or malaria infections were associated with greater odds of anemia, wasting, and/or stunting; for girls, heavy S. haematobium infection and age were the significant cofactors for anemia, whereas low SES and older age were linked to stunting. The broad overlap of infection-related causes for anemia and malnutrition and the high frequency of polyparasitic infections suggest that there will be significant advantages to integrated parasite control in this area.

show abstract

Long-term outcomes of school-based treatment for control of urinary schistosomiasis: a review of experience in Coast Province, Kenya

Abstract: Urinary schistosomiasis remains a significant burden for Africa and the Middle East. The success of populationbased control programs will depend on their impact, over many years, on Schistosoma haematobium reinfection and associated disease. In a multi-year (1984-1992)

Cited by 33 publications

References 32 publications

Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: Efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001

Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: Efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001

Helminth infections: the great neglected tropical diseases

Impact of Polyparasitic Infections on Anemia and Undernutrition among Kenyan Children Living in a Schistosoma haematobium-Endemic Area

Contact Info

Product

Resources

About