Long-term outcomes of preterm infants treated with less invasive surfactant technique (LISA)

Isidro, Elena Márquez; Luna, Manuel Sánchez; Ramos‐Navarro, Cristina

doi:10.1080/14767058.2019.1651276

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…Data reported in abstract form from the 5-year follow-up of LISA infants in the GNN cohort suggest better lung function (FEV 1 ) and better neuro-outcome/intellectual properties (WPPSI score) in infants that received surfactant via LISA compared to infants that received surfactant via the standard route ( 13 ). Again, all these studies and 2 recently published studies from Spain ( 14 , 15 ) using historical controls were non-randomized, so that selection bias is likely to account for part of the positive results that were observed in favour of LISA.…”

Section: Discussionmentioning

confidence: 99%

Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

et al. 2020

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Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment.Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation. What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.

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Section: Discussionmentioning

confidence: 99%

Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

et al. 2020

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“…Follow‐up data of LISA‐treated infants are scarce and primarily include data from observational studies 4‐6 . In 2010, Porath et al 5 reported school age outcome of the first cohort of LISA‐treated infants from Cologne compared to a historical control group.…”

Section: Discussionmentioning

confidence: 99%

“…Infants in the cohort of LISA‐treated infants scored better than infants of the historical control cohort MDI 98 vs 89, P = 0.16 and PDI 91 vs 83, P = 0.03), but follow‐up rates were low with only 52% of discharged infants. Recently, a Spanish group reported follow‐up data from 28 LISA‐treated infants with a gestational age below 32 weeks compared to 29 infants of a historical control 6 receiving surfactant via INSURE (Intubation‐SURfactant‐Extubation) method. Infants were assessed for neurodevelopment with the Brunet‐Lezine score.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, data on long‐term outcome after LISA compared to intubation are scarce. Few observational studies suggested a potential benefit if surfactant is applied via LISA 4‐6 . However based on the lack of data from randomised trials, there are still safety concerns regarding long‐term outcome especially outside of Europe 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Few observational studies suggested a potential benefit if surfactant is applied via LISA. [4][5][6] However based on the lack of data from randomised trials, there are still safety concerns regarding long-term outcome especially outside of Europe. 7 LISA reduces duration of ventilation and risk of bronchopulmonary dysplasia (BPD), both well-defined risk factor of adverse development.…”

Section: Introductionmentioning

confidence: 99%

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Developmental outcome of extremely preterm infants is improved after less invasive surfactant application: Developmental outcome after LISA

et al. 2020

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Aim The aim of this study was to evaluate neurocognitive outcome at 24 months of corrected age after less invasive surfactant application (LISA) in preterm infants born at 23‐26 weeks of gestational age. Methods Surviving participants of a LISA trial conducted in 13 German level III neonatal intensive care units were reviewed for assessment of developmental outcome, hearing and vision problems, growth and rehospitalisation days. Maternal depression, breastfeeding rates and socio‐economic factors were evaluated as potentially confounding factors. Results In total, 156/182 infants took part in the study, 78 had received surfactant via LISA and 78 via endotracheal intubation. 22% of LISA infants compared to 42% of intubated infants had a psychomotor development index (PDI) <70 (0.012). A significant difference in mental development index (MDI) was observed in the stratum of more mature infants (25 and 26 weeks of GA). For this group, MDI < 70 was observed in 4% of LISA infants vs 21% of intubated infants (P = 0.008). Conclusion At 24 months of age, the LISA‐treated infants scored less often PDI < 70 and had similar results in MDI. Infants born at 25 and 26 weeks treated with LISA had lower rates of severe disability. LISA is safe and may be superior.

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Surfactant delivery via thin catheters: Methods, limitations, and outcomes

Devi

Pandita

2021

Pediatric Pulmonology

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Various less invasive surfactant administration strategies like surfactant replacement therapy via thin catheters, laryngeal mask airway, pharyngeal instillation, and nebulized surfactant are increasingly being practiced to avoid the harmful effects of endotracheal intubation and ventilation. Numerous studies have been done to study surfactant replacement via thin catheters whereas little data is available for other methods. However, there are variations in premedication policies, type of respiratory support used in these studies. Surfactant delivery using thin catheters has been reported to be associated with decrease in the need for mechanical ventilation (MV), duration of MV, bronchopulmonary dysplasia and neonatal mortality. With the current evidence, among all the available surfactant delivery methods, the one using thin catheters appears to be the most feasible and beneficial to improve clinical neonatal outcomes.

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Long-term outcomes of preterm infants treated with less invasive surfactant technique (LISA)

Cited by 15 publications

References 20 publications

Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

Developmental outcome of extremely preterm infants is improved after less invasive surfactant application: Developmental outcome after LISA

Surfactant delivery via thin catheters: Methods, limitations, and outcomes

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