Long-term outcomes of pediatric inflammatory bowel disease

Nasiri, Soheila; Kuenzig, M Ellen; Benchimol, Eric I

doi:10.1053/j.sempedsurg.2017.10.010

Cited by 41 publications

(17 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the use of therapies to better control inflammation and routine endoscopic screening for adult IBD patients to efficiently reduce CRC risks, some epidemiological studies still reveal an association between IBD and CRC [17]. Of note, the axis between intestinal inflammation and cancer development is especially true for patients diagnosed with IBD during the pediatric years, particularly for UC patients [9,10,18].…”

Section: Discussionmentioning

confidence: 99%

Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation

Santis

Verna

Serino

et al. 2020

IJMS

View full text Add to dashboard Cite

1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with Apc Min/+ mice. (3) Results: The resulting Winnie-Apc Min/+ model combines an inflammatory background with a genetic predisposition to small intestinal polyposis. Winnie-Apc Min/+ mice show an early occurrence of inflammatory signs and dysplastic lesions in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie-Apc Min/+ model is a perfect model to demonstrate that chronic inflammation represents a crucial risk factor for the onset and progression of tumoral lesions in individuals genetically predisposed to CRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation

Santis

Verna

Serino

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…IBD may lead to several considerable complications associated not only with gastrointestinal manifestation, but can also affect other relevant systems [ 2 – 6 ]. This contributes to poor quality of life (QoL) in IBD patients.…”

Section: Introductionmentioning

confidence: 99%

Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

et al. 2018

View full text Add to dashboard Cite

Psychiatric disorders are significantly common complications among patients suffering from inflammatory bowel diseases (IBD). Affective temperament is a concept of core personality traits, which can decribe the vulnerability to mood disorders, therefore its evaluation might convey useful information about patients' mental status in autoimmune disorders. The aim of the study was to evaluate the affective temperament in patients with Crohn's disease (CD) and ulcerative colitis (UC) as characteristic features of these diseases, but also in the clinical course and the severity of anxiety and depression.Due to our knowledge this is the first study of this kind. The study enrolled 130 patients with IBD, including 68 with CD and 62 with UC. We used TEMPS-A to evaluate affective temperament and HADS scales to assess the intensity of depressive and anxiety symptoms. Harvey Bradshaw scale, Crohn’s Disease Activity Index (CDAI) and Mayo Score were used to evaluate clinical severity of the diseases. We observed significantly higher prevalence of depressive, cyclothymic and anxiety temperaments in CD patients compared to the control group. Harvey Bradshaw scale, CDAI and Mayo Self Report showed statistically significant outcomes, including significant positive correlations with depressive, cyclothymic and anxiety subscales of TEMPS-A, and negative correlation with the hyperthymic temperament in CD subjects. Our findings indicate significant differences between CD and UC due to temperament traits, and suggest distinct pathogenesis of mood disorders in IBD.

show abstract

“…In a French cohort study, active disease, defined as the occurrence of a flare-up or a complication during each year between 1995 and 2007, was more frequently observed in pediatric-onset than adult-onset CD patients (37% vs. 31% of patient-years, p <0.001) between 1995 and 2007 (a total of 6,585 patient-years evaluated) [34]. Progression to stricturing or penetrating phenotypes (B2 or B3) from inflammatory behavior (B1) was reported in 24% to 43% and 14% to 44% of pediatric-onset CD patients, respectively [35]. New perianal complications developed in 10% to 20% of patients between 5 and 10 years after the diagnosis of CD [19].…”

Section: Epidemology and Clinical Characteristics Of Pediatric-onset mentioning

confidence: 99%

“…According to a population-based study from France and a cohort study from the United States, 29% and 11.3% of pediatric-onset CD patients did not reach their target height, respectively [4243]. Since the largest increases in bone mass occurs between the ages of 12 to 15 years in girls and 14 to 17 years in boys, adequate bone mass may not be achieved, and the risk of fracture could increase in pediatric-onset IBD patients [3544]. Furthermore, a significant proportion of pediatric-onset CD patients suffer from growth retardation and undernutrition during the course of the disease [19].…”

Section: Epidemology and Clinical Characteristics Of Pediatric-onset mentioning

confidence: 99%

Successful Transition from Pediatric to Adult Care in Inflammatory Bowel Disease: What is the Key?

Kim

2019

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Furthermore, successful transition facilitates appropriate development and psychosocial well-being among patients, as well as comprehensive and harmonious healthcare delivery amongst stakeholders. However, there are various obstacles related to patients, family, providers, and organizations that interfere with successful transition. Successful transition requires a flexible and tailored plan that is made according to the patient's developmental abilities and situation. This plan should be established through periodic interviews with the patient and family and through close collaboration with other care providers. Through a stepwise approach to the transition process, patients' knowledge and self-management skills can be improved. After preparation for the transition is completed and the obstacles are overcome, patients can be gradually moved to adult care. Finally, successful transition can increase patients' adherence to therapy, maintain the appropriate health status, improve patients' self-management, and promote self-reliance among patients.

show abstract

Long-term outcomes of pediatric inflammatory bowel disease

Cited by 41 publications

References 102 publications

Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation

Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation

Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

Successful Transition from Pediatric to Adult Care in Inflammatory Bowel Disease: What is the Key?

Contact Info

Product

Resources

About