2014
DOI: 10.4174/astr.2014.87.2.61
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Long-term outcomes of intraoperative and perioperative albendazole treatment in hepatic hydatidosis: single center experience

Abstract: PurposeThe aim of this study was to evaluate long-term outcome of the intraoperative and perioperative albendazole (ALB) treatment on the recurrence and/or secondary hydatidosis.MethodsOne hundred and one patients with hepatic hydatidosis were treated intraoperatively and perioperatively with ALB, in addition to surgery. Perioperative ALB treatment was given in a dose of 12-15 mg/kg/day. The ALB treatment was started 13.27 ± 14.34 days before the surgery, and it was continued for 4.39 ± 3.11 months postoperati… Show more

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Cited by 15 publications
(14 citation statements)
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“…Because ABZ is nowadays considered a relatively safe drug, continuous therapy is preferred over discontinuous treatment protocols. The reported side effects were more frequent hepatotoxicity, alopecia, and gastrointestinal disturbances and less common jaundice, severe headache, cough, jaundice, vertigo, and itching [16]. ABZ is embryotoxic and teratogenic in pregnant women [17].…”
Section: The Current State Of Knowledgementioning
confidence: 99%
“…Because ABZ is nowadays considered a relatively safe drug, continuous therapy is preferred over discontinuous treatment protocols. The reported side effects were more frequent hepatotoxicity, alopecia, and gastrointestinal disturbances and less common jaundice, severe headache, cough, jaundice, vertigo, and itching [16]. ABZ is embryotoxic and teratogenic in pregnant women [17].…”
Section: The Current State Of Knowledgementioning
confidence: 99%
“…Because ABZ is nowadays considered a relatively safe drug, continuous therapy is preferred over discontinuous treatment protocols. Recent descriptive studies based on case series have evidenced that the frequency of undesirable side effects attributable to ABZ ranged from 3–5% [ 58 , 78 , 79 ], with some surveys reporting none [ 80 ]. The adverse reactions more frequently described were jaundice, severe headache, cough, hemoptysis, altered levels of serum transaminases, vertigo, loss of hair, and itching [ 58 , 78 , 79 ].…”
Section: Introductionmentioning
confidence: 99%
“…Recent descriptive studies based on case series have evidenced that the frequency of undesirable side effects attributable to ABZ ranged from 3–5% [ 58 , 78 , 79 ], with some surveys reporting none [ 80 ]. The adverse reactions more frequently described were jaundice, severe headache, cough, hemoptysis, altered levels of serum transaminases, vertigo, loss of hair, and itching [ 58 , 78 , 79 ]. Despite the fact that ABZ and ABZSO have been demonstrated teratogenic in rats and rabbits at 6–30 mg -1 ·kg -1 ·day -1 , examination of 49 case histories of women prescribed with ABZ for the treatment of various helminthic infections during the first trimester of pregnancy failed to demonstrate congenital abnormalities associated to drug exposure [ 81 ].…”
Section: Introductionmentioning
confidence: 99%
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