Long-Term Outcomes of IMRT for Breast Cancer: A Single-Institution Cohort Analysis

Modulated Radiotherapy for Breast Cancer: Locoregional Outcomes

“…20 Similarly McDonald et al have shown that IMRT results in lesser grade 2-3 dermatitis as compared to conventional 3DCRT. 17 These results have been consistent in other studies as well. In our study, we did not note a significant difference in skin toxicity between the various techniques; however, the proportion of patients who were treated with tangents or 3DCRT was small and a meaningful comparison could not have been made.…”

“…They found no statistically significant difference in 5year locoregional recurrence rates (2.56% vs 1.35%) or overall survival (92.5% vs 91.7%). 16 Additionally, two studies have evaluated breast cancer related outcomes, the retrospective study by McDonald et al and the prospective sutdy by Mc Donald MW et al, 17 Morganti et al 18 None of these studies reported a statistically significant difference in survival, disease-specific survival or freedom from contralateral breast cancer recurrence between IMRT and non-IMRT techniques. These data have established the role of IMRT as a non-inferior technique with respect to the oncologic outcomes while solidifying its superiority in terms of adverse effects, specifically skin toxicity owing to better dose homegeneity in IMRT plans compared to 3DCRT or tangential field plans.…”

The Impact of Immediate Breast Reconstruction on the Technical Delivery of Postmastectomy Radiotherapy

“…In fact, it is difficult to assess cardiac morbidity particularly from studies as the present one with relatively short follow up period due to the long latency for such side effects which may extend to 20 years. Finally, the more recent irradiation technique, intensity modulated radiation therapy (IMRT) has been introduced in the adjuvant treatment of breast cancer aiming at reducing acute toxicity and the dose to the critical organs as heart and lung with proved efficacy [21].…”

Treatment with intensity-modulated radiation therapy (IMRT) for breast cancer

“…Some institutional series reported a low rate of delayed toxicity related to radiation therapy: a study with 7.5 years of median follow-up reports rates of delayed skin toxicity grade II or higher at 39 vs. 52% (p=0.004) with IMRT and conventional radiotherapy, respectively (D). 18 Rates of pneumonitis, lymphoedema, and tumor recurrence within the follow-up were not statistically different between the two groups (D). 18 A similar study showed after 4.7 years of median follow-up that the use of IMRT reduces the rates of acute and delayed toxicity, with respective rates of delayed breast edema grade II or higher at 6 versus 1% (p=0.009) (B).…”

“…18 Rates of pneumonitis, lymphoedema, and tumor recurrence within the follow-up were not statistically different between the two groups (D). 18 A similar study showed after 4.7 years of median follow-up that the use of IMRT reduces the rates of acute and delayed toxicity, with respective rates of delayed breast edema grade II or higher at 6 versus 1% (p=0.009) (B). 19 For patients with larger breasts (volume > 1,600cm 3 ), the gains were more expressive with IMRT: chronic breast edema (3 vs. 30%, p=0.007) and hyperpigmentation (3 vs. 41%, p=0.001)(B).…”