Long-Term Outcomes of Immunohistochemically Defined Subtypes of Breast Cancer Less Than or Equal to 2 cm After Breast-Conserving Surgery

Pata, Giacomo; Guaineri, A.; Bianchi, Anna; Amoroso, Vito; Pasinetti, Nadia; Pasini, M

doi:10.1016/j.jss.2018.11.028

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…[ 14 ] There are other studies reporting that liver metastasis is not associated with breast cancer subtypes. [ 26 ] Another study suggested that ER-negative patients have more visceral involvement than ER-positive patients. [ 27 ] Although these observations are important for deciding on treatment and developing appropriate research strategies, they are not sufficient to elucidate the underlying mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Review of the relationship between tumor receptor subtypes and preference for visceral and/or serosal metastasis in breast cancer patients

Özdemir Akdur,

Çiledağ

2023

Medicine

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In this study, we investigated the molecular phenotype–cancer relationship that may favor the main metastatic tendencies of cancer by comparing the association of receptor subtypes with the presence of metastasis, serosal metastasis, and/or visceral metastases in patients diagnosed with breast cancer. In this study, we retrospectively evaluated 853 patients who were diagnosed with breast cancer and followed up at our hospital between 2017 and 2022. The probability of metastasis in the most common tumor group, the non-special type of invasive carcinoma was significantly higher than that in other tumor groups. We formed our groups according to estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki67 status. In addition, when we compared the receptor groups, no significant difference was found between the receptor groups (Table 1). When the entire breast cancer cohort was considered, the association of serosal metastasis was statistically significantly higher in the ER and/or PR (+) and, HER2 (−) receptor subgroup than in all other receptor groups (P < .006), and the association of visceral metastasis/visceral + serosal metastasis with the ER and/or PR (+) and, HER2 (−) receptor subgroup was significantly higher than that in all other receptor groups (P < .001) (Table 2). In this study, we aimed to investigate the possible relationship between molecular markers of the primary tumor and the preference for serosal and visceral metastases over distant metastases in a large cohort of patients to contribute to the improvement of the diagnosis and treatment of breast cancer, a heterogeneous disease group. To the best of our knowledge, our study is the first to statistically investigate the association between receptor subgroups and visceral, serosal, and serosal + visceral metastases as a group and to reach some conclusions.

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Section: Discussionmentioning

confidence: 99%

Review of the relationship between tumor receptor subtypes and preference for visceral and/or serosal metastasis in breast cancer patients

Özdemir Akdur,

Çiledağ

2023

Medicine

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“…During follow-up, chemotherapy and hormonal therapy were used as adjuvant treatment. Some of the above-mentioned factors (associated in situ carcinoma, LVI, high histological grade, high ki 67% and progesterone receptor negative) are typical factors known to be related to local relapse [27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Complications and local relapse after intraoperative low-voltage X-ray radiotherapy in breast cancer

et al. 2020

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To study those factors that influence the occurrence of surgical complications and local relapse in patients intervened for breast cancer and receiving intraoperative radiotherapy. Methods: Observational study on patients intervened for breast cancer with conservative surgery and intraoperative radiotherapy with low-voltage X-ray energy source (INTRABEAM), from 2015 to 2017 with 24 months minimum followup. Variables possibly associated to the occurrence of postoperative complications were analyzed with the Student t-test and the Fisher exact test; P < 0.05 considered significant. Subsequently, the construction of multiple multivariate analysis models began, thus building a logistic regression analysis using the IBM SPSS Statistics ver. 23 software. Local relapse was described. Results: The study included 102 patients, mean age of 61.2 years; mean global size of tumor, 12.2 mm. Complications occurred in 29.4%. Fibrosis was the most frequently observed complication, followed by postoperative seroma. Using a 45 mm or larger applicator were significantly associated with the occurrence of complications. Tumor size 2 cm or larger and reintervention showed borderline significant association. Only one case of local relapse was observed. Conclusion: Certain factors may increase the risk of complication after the use of intraoperative radiotherapy. Using external complementary radiotherapy does not seem to increase the rate of complications. Select patients and the involvement of a multidisciplinary team are essential for achieving good results.

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“…The following immunohistochemically defined subtypes were considered 14 : LumA (ER+ and/or PR+, HER2−, and Ki‐67 index <20%), LumB/HER2− (ER+ and/or PR+, HER2−, and Ki‐67 index ≥20%), LumB/HER2+ (ER+ and/or PR+ and HER2+), HER2+ (ER−, PR−, and HER2+), and TN (ER−, PR−, and HER2−). If there was an absence of either ER, PR, HER2, or Ki‐67 index data, the subtype was labeled as not specified.…”

Section: Methodsmentioning

confidence: 99%

Identification of risk factors for central nervous system metastasis in patients with breast cancer with neurologic symptoms

Cacho-Díaz

Salmerón-Moreno

Alvarez-Alvarez

et al. 2020

Cancer

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Background The current study was performed to identify factors that are present at the time of breast cancer (BC) diagnosis that are associated with a higher rate of central nervous system metastasis (CNSm). Methods The authors analyzed a database of patients with a confirmed diagnosis of BC who were referred for a neuro‐oncology consultation at the National Cancer Institute in Mexico City, Mexico, from June 2009 to June 2017. Information was collected prospectively and included demographic, pathologic, and clinical data at the time of diagnosis of BC. Bivariate and multivariate logistic regression models were built to estimate the associations between the development of CNSm and the time after BC diagnosis. Results Among 970 patients with BC, 263 (27%) were diagnosed with CNSm. The median time from BC diagnosis to the development of CNSm was 33 months (interquartile range, 15‐76 months). After multivariate analysis, age <50 years at the time of BC diagnosis (odds ratio [OR], 2.5; 95% confidence interval [95% CI], 1.8‐3.5 [P < .0001]), human epidermal growth factor receptor 2 (HER2)–positive status (HER2+) (OR, 3.6; 95% CI, 2.1‐6.1 [P < .0001]), luminal B/HER2+ subtype (OR, 3.1; 95% CI, 1.9‐5.3 [P < .001]), triple‐negative subtype(OR, 2.4; 95% CI, 1.5‐4 [P = .001]), and Karnofsky performance status ≤70 (OR, 6.6; 95% CI, 4.5‐9.6 [P < .0001]) were associated with a higher frequency of CNSm. Brain parenchyma was the most common site of CNSm. The median overall survival after a diagnosis of CNSm was 12.2 months (95% CI, 9.3‐15.1 months). Conclusions CNSm is not uncommon among patients with BC, particularly in those with neurologic symptoms who require neuro‐oncology evaluation and are aged <50 years at the time of diagnosis, have HER2+ or triple‐negative subtypes, have a poor Karnofsky performance status, and/or have ≥2 non‐CNS metastases.

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Long-Term Outcomes of Immunohistochemically Defined Subtypes of Breast Cancer Less Than or Equal to 2 cm After Breast-Conserving Surgery

Cited by 8 publications

References 31 publications

Review of the relationship between tumor receptor subtypes and preference for visceral and/or serosal metastasis in breast cancer patients

Review of the relationship between tumor receptor subtypes and preference for visceral and/or serosal metastasis in breast cancer patients

Complications and local relapse after intraoperative low-voltage X-ray radiotherapy in breast cancer

Identification of risk factors for central nervous system metastasis in patients with breast cancer with neurologic symptoms

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