Long-term outcomes of idiopathic membranous nephropathy in Japanese patients treated with low-dose cyclophosphamide and prednisolone

Abstract

Treating nephrotic IMN in Japanese patients with low-dose cyclophosphamide and prednisolone is beneficial for long-term renal prognosis with relatively few adverse effects.

Membranous Nephropathy with an Enhanced Granular Expression of Thrombospondin Type-1 Domain-containing 7A in a Pregnant Woman

“…Troyanov et al reported that the mean time to complete remission was 30 months in patients with idiopathic MN with nephrotic syndrome (25). Eriguchi et al reported that the cumulative incidences for complete remission at 1, 2 and 5 years were 39.8, 60.8 and 76.1% in Japanese patients with idiopathic MN (26). We reviewed the response to immunosuppressive agents in pregnant women with MN and that in our patients with THSD7A-related MN.…”

Meta-Analysis of Association between Pathological Characteristics and Renal Outcomes in Adult Idiopathic Membranous Nephropathy

“…A total of 2080 patients with 252 hard endpoints (renal insufficiency or ESRD) were reported [16,19,[31][32][33]35,[38][39][40]. Seven studies reported the number of patients who developed renal insufficiency during follow-up, and eight studies reported the number of patients who reached ESRD during follow-up.…”

“…Eriguchi et al found that interstitial fibrosis was associated with renal sufficiency by univariate analysis [39]. However, multivariate analysis failed to confirm the independently predictive value of interstitial fibrosis in 103 consecutive Japanese nephrotic IMN patients.…”

“…of trials Hazard ratio (95% CI) P-subgroup difference [33,39]. Sprangers et al described 132 IMN patients who were followed for a mean period of 68 months and analyzed the pathological features that predicted renal outcomes [38].…”

“…Five studies failed to identify a significant association of arteriosclerosis with renal outcomes in multivariate analysis [19,[31][32][33]35]. The remaining three studies did not examine the association of arteriosclerosis with renal outcomes [38][39][40]. The association of arteriosclerosis with renal outcomes was quantitatively summarized in five of nine included studies with 1349 patients.…”