Long-term outcomes of elderly patients with peritoneal metastases of colorectal origin after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Weksler, Yael; Hoffman, Aviad; Green, Eraan; Kyzer, Matan; Nevo, Nadav; Gerstenhaber, Fabian; Greenberg, Ron; Klausner, Joseph M.; Gutman, Mordechai; Lahat, Guy; Berger, Yaniv; Nizri, Eran

doi:10.1016/j.suronc.2022.101848

Surgical Oncology

2022

DOI: 10.1016/j.suronc.2022.101848

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Long-term outcomes of elderly patients with peritoneal metastases of colorectal origin after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Yael Weksler

Aviad Hoffman

Eraan Green

et al.

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2023

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Study on the anticancer effect and mechanism of action of reactive species in plasma‐activated solution against colorectal cancer cells

Hu,

Peng,

et al. 2023

Plasma Processes & Polymers

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Reactive species (RS) are the key factors of plasma‐activated solutions (PAS) against cancer. However, the specific contribution of each RS in inducing cancer cell death remain unclear. Therefore, this study aimed to evaluate the anticancer potential and mechanism of plasma‐activated medium (PAM) and plasma‐activated phosphate buffer saline (PA‐PBS) in vitro using colorectal cancer cells HCT116. Results showed that PAM and PA‐PBS effectively inhibited the growth and proliferation of HCT116 cells, with PA‐PBS exhibiting greater potency. H2O2, intracellular reactive oxygen species, and pH (H+) were essential mediators of cell death, and ONOO− exhibited cytotoxicity only after reaching a specific concentration. Additionly, PAS induced cell death through the exogenous apoptotic pathway.

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Study on the anticancer effect and mechanism of action of reactive species in plasma‐activated solution against colorectal cancer cells

Hu,

Peng,

et al. 2023

Plasma Processes & Polymers

View full text Add to dashboard Cite

show abstract

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Long-term outcomes of elderly patients with peritoneal metastases of colorectal origin after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Cited by 1 publication

References 36 publications

Study on the anticancer effect and mechanism of action of reactive species in plasma‐activated solution against colorectal cancer cells

Study on the anticancer effect and mechanism of action of reactive species in plasma‐activated solution against colorectal cancer cells

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