Long‐term outcomes of early stage oral tongue cancer: Main cause of treatment failure and second primary malignancy

Park, Young Min; Lim, Jae‐Yol; Koh, Yoon Woo; Kim, Se‐Heon; Choi, Eun Chang

doi:10.1002/lio2.943

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Organ preservation therapy is becoming increasingly common in the modern era for the primary management of tumors of multiple head and neck subsites with equal oncological outcomes to surgical resection [ 19 ]. Concurrent chemoradiotherapy as an initial treatment for OTSCC has been shown to produce five-year disease survival, ranging from 84.8% to 91.2% [ 20 , 21 ]. Brachytherapy has been shown to result in excellent local tumor control.…”

Section: Discussionmentioning

confidence: 99%

Oncologic Outcomes of Salvage Surgery in Recurrent Oral Tongue Squamous Cell Carcinoma

Farsi,

Amole,

King

et al. 2024

Cureus

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Objective: This study aimed to determine the oncologic outcomes and identify prognostic factors in patients undergoing salvage glossectomy for recurrent oral tongue squamous cell carcinoma (OTSCC). Methods: A retrospective chart review was conducted encompassing all patients who underwent salvage oral glossectomy out of 259 individuals undergoing oral glossectomy at a tertiary academic center. Inclusion criteria comprised patients who met the following conditions: 1) biopsy-proven oral tongue recurrence, 2) salvage glossectomy performed with curative intent, 3) availability of imaging records, and 4) comprehensive documentation. Cases involving base of tongue tumors and second primaries were excluded from the analysis. Categorical data were expressed as proportions, and continuous data as medians/quartiles. Univariate analysis used Fisher’s exact test for categorical variables and Student’s t-test for continuous ones. Survival analysis employed Kaplan-Meier estimates and the log-rank test. Results: High-risk histopathological risk factors were significantly more common with recurrence compared to initial presentation. The mean locoregional disease-free interval was 35 months. Kaplan-Meier estimates for one- and three-year disease-free survival (DFS) were 62.7% and 33.4%, while disease-specific survival (DSS) rates were 73% and 38.9%, respectively. Recurrent T-stage was a predictor for DFS, while margin status was a strong predictor for both LR control (p = 0.024) and DSS (p = 0.030), as was perineural invasion (p = 0.001 and p = 0.030). Alcohol use was associated with worse overall survival (p = 0.024). In contrast to other reports, nodal status was not a predictor in this series. Conclusions: Upon recurrence, histopathological analysis unveils detrimental changes in tumor biology, which significantly influence disease control. Notably, consistent with findings from other studies, factors, such as recurrent T-stage, presence of perineural invasion, and, most importantly, margin status, play pivotal roles in determining oncologic outcomes. Consequently, the imperative for aggressive salvage surgery becomes evident in achieving sufficient disease control. This underscores the necessity for proactive management strategies aimed at addressing these factors to enhance patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Oncologic Outcomes of Salvage Surgery in Recurrent Oral Tongue Squamous Cell Carcinoma

Farsi,

Amole,

King

et al. 2024

Cureus

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High expression of serine protease inhibitor kazal type 1 predicts poor prognosis and promotes the progression and invasion of oral tongue squamous cell carcinoma

Wang,

Sun,

Shao

et al. 2024

Archives of Oral Biology

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Web‐based prognostic tools for oral tongue cancer: An analysis of online predictors

Wahab,

Bello,

Alabi

et al. 2024

Oral Diseases

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BackgroundOral tongue squamous cell carcinoma (OTSCC) often presents with aggressive clinical behaviour that may require multimodality treatment based on reliable prognostication. We aimed to evaluate the prognostic ability of five online web‐based tools to predict the clinical behaviour of OTSCC resection and biopsy samples.MethodsA total of 135 OTSCC resection cases and 33 OTSCC biopsies were included to predict recurrence and survival. Area under the receiver operating characteristic curves (AUC), χ2 tests, and calibration plots constructed to estimate the prognostic power of each tool.ResultsThe tool entitled ‘Prediction of risk of Locoregional Recurrences in Early OTSCC’ presented an accuracy of 82%. The tool, ‘Head & Neck Cancer Outcome Calculator’ for 10‐year cancer‐related mortality had an accuracy 77% and AUC 0.858. The other tool entitled ‘Cancer Survival Rates’ for 5‐year mortality showed an accuracy of 74% and AUC of 0.723. For biopsy samples, ‘Cancer Survival Prediction Calculators’ predicted the recurrence free survival with an accuracy of 70%.ConclusionsWeb‐based tools can aid in clinical decision making of OTSCC. Three of five online web‐based tools could predict recurrence risk and cancer‐related mortality in resected OTSCC and one tool could help in clinical decision making for biopsy samples.

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Long‐term outcomes of early stage oral tongue cancer: Main cause of treatment failure and second primary malignancy

Cited by 3 publications

References 33 publications

Oncologic Outcomes of Salvage Surgery in Recurrent Oral Tongue Squamous Cell Carcinoma

Oncologic Outcomes of Salvage Surgery in Recurrent Oral Tongue Squamous Cell Carcinoma

High expression of serine protease inhibitor kazal type 1 predicts poor prognosis and promotes the progression and invasion of oral tongue squamous cell carcinoma

Web‐based prognostic tools for oral tongue cancer: An analysis of online predictors

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