Long-Term Outcomes of Early-Stage Nasopharyngeal Carcinoma Patients Treated With Intensity-Modulated Radiotherapy Alone

Su, Sheng; Han, Fei; Zhao, Chong; Chen, Chun Yan; Xiao, Weiwei; Li, Jia Xin; Lu, Tai Xiang

doi:10.1016/j.ijrobp.2010.09.011

Cited by 190 publications

(174 citation statements)

References 26 publications

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“…This is in contrast to common treatment protocols of adult NPC patients, in which total irradiation doses of at least 66 Gy or even !70 Gy are recommended and applied. 6,7,[39][40][41] Other approaches to overcome the impaired immunity to EBV in patients with NPC, like cell therapy with autologous, EBV-targeted T-lymphocytes [42][43][44] or whole-tumor antigenpulsed dendritic cells, 45 are promising but not yet available for routine application.…”

Section: Discussionmentioning

confidence: 99%

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Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

Buehrlen

Zwaan

Granzen

et al. 2012

Cancer

105

146

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BACKGROUND:The authors report preliminary results from a prospective multicenter study (Nasopharyngeal Carcinoma [NPC] 2003 German Society of Pediatric Oncology and Hematology/German Children's Oncology Group [NPC‐2003‐GPOH/DCOG]).METHODS:From 2003 to 2010, 45 patients (ages 8‐20 years), including 1 patient with stage II NPC and 44 patients with stage III/IV NPC, were recruited to the study. The patient with stage II disease received radiotherapy (59.4 grays [Gy]). The patients with stage III/IV disease received 3 courses of neoadjuvant chemotherapy with cisplatin, 5‐fluorouracil, and folinic acid. The cumulative irradiation dose was 54 Gy in 5 patients, who achieved complete remission after neoadjuvant chemotherapy, and 59.4 Gy in the remaining 40 patients. All patients received concomitant cisplatin during the first week and last week of irradiation. After irradiation, all patients received interferon beta for 6 months. Tumor response was evaluated by magnetic resonance imaging studies and positron emission tomography scans.RESULTS:After the completion of treatment, 43 of 45 patients were in complete remission. In 2 patients, only a partial response was achieved, followed by distant metastases (1 patient) or local progression and distant metastases (1 patient), 6 months and 10 months after diagnosis, respectively. Another patient developed a solitary pelvic bone metastasis 21 months after diagnosis. After a median follow‐up of 30 months (range, 6‐95 months), the event‐free survival rate was 92.4%, and the overall survival was 97.1%. Acute toxicity consisted mainly of leucopenia, mucositis, and nausea; and late toxicity consisted of hearing loss and hypothyroidism.CONCLUSIONS:Combined therapy with neoadjuvant chemotherapy, radiochemotherapy, and interferon beta was well tolerated and resulted in a very good outcome that was superior to the outcomes of published results from all other pediatric NPC study groups. Cancer 2012. © 2012 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

“…For adults with early stage NPC, radiation therapy remains the mainstay of treatment. [5][6][7] For patients with advanced disease, the benefit of additional chemotherapy has been demonstrated. 1,8,9 Children and adolescents usually present with advanced stage disease.…”

Section: Introductionmentioning

confidence: 99%

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

Buehrlen

Zwaan

Granzen

et al. 2012

Cancer

105

146

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“…So targeting of Plk1 to inhibit its overexpression will promote mitotic catastrophe and cell cycle arrest. This strategy has the potential to become an extremely powerful therapeutic approach when combined with effective ionizing radiation [61,62].…”

Section: Mirna and Mitosismentioning

confidence: 99%

miRNA and nasopharyngeal carcinoma

2011

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MicroRNAs (miRNAs) constitute a family of small non-coding RNA molecules 22-25 nucleotides in length. miRNAs control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3′-untranslated regions. Recent studies have demonstrated that miRNAs are intimately involved in processes leading to nasopharyngeal carcinoma, such as the Epstein-Barr virus-encoded latent membrane protein 1 activated signal transduction pathways, gene-regulatory networks, mitosis, tumor angiogenesis, invasion and migration. Exploring the relationship between miRNAs and the development of nasopharyngeal carcinoma, will further the understanding of this cancer and provide new avenues for diagnosis and treatment. . Nasopharyngeal carcinoma (NPC) is a head and neck epithelial malignancy that occurs frequently in Southern China [2]. It is characterized by high invasiveness and metastasis, and involves Epstein-Barr virus (EBV) infection and numerous genetic factors [3]. In this review, we focus on recent studies [4] that have described miRNA involvement in the carcinogenesis of NPC.1 miRNA biogenesis, regulatory mechanisms and biological functions 1.1 miRNA biogenesis and regulatory mechanisms miRNAs are small non-coding RNA molecules of about *Corresponding author (email: Lqz2010@hotmail.com; xiaoqing1213@sina.com) 22-25 nucleotides in length. miRNA genes are first transcribed by RNA polymerase II, to produce molecules hundreds of nucleotides in length, called pri-miRNAs. Then, Drosha, an RNA polymerase III, processes pri-miRNAs into stem-loop structures, 60-70 nucleotides in length, called pre-miRNAs. The transportation protein, Exportin-5, identifies and combines with the 3′-end of pre-miRNAs and, in a Ran-GTP-dependent manner, pre-miRNAs are exported from the nucleus into cytoplasm. With the involvement of another RNase III Dicer, the pre-miRNAs are further cleaved into double stranded RNAs (dsRNAs). A helicase then degrades one strand of the dsRNA, leaving the other strand a mature active miRNA to enter the nucleus and form the miRNA-associated RNA-induced silencing complex (miRISC) [5][6][7]. Within this complex, miRNAs can play essential roles in biological functions.miRNAs control the expression of target genes at the post-transcriptional level by inhibiting protein translation or by degrading cognate target mRNAs through binding to their 3′-untranslated regions (UTRs) with varying degrees of sequence complementarity. miRNAs are also involved in

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“…The 5-year overall survival rate ranges between 84 and 90% for early-stage NPC patients (2), whereas advanced stages have a poor 5-year overall survival rate of 30.3-73.6% (3). Therefore, early detection and diagnosis are critical to prevent the advancement of NPC and improve the 5-year overall survival rate.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy

Qiu

Huang

et al. 2015

Oncology Letters

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Abstract. The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS spectra were tentatively assigned to various saliva components. The saliva SERS spectra obtained from the NPC patients and the healthy volunteers were also analyzed by multivariate statistical techniques based on principal component analysis and linear discriminant analysis (PCA-LDA). Significant differences were observed between the saliva SERS spectral intensities for NPC patients and healthy volunteers, particularly at 447, 496, 635, 729, 1134, 1270 and 1448 cm -1 , which primarily contained signals associated with proteins, nucleic acids, fatty acids, glycogen and collagen. The classification results based on the PCA-LDA method provided a relatively high diagnostic sensitivity of 86.7%, specificity of 81.3% and diagnostic accuracy of 83.9% for NPC identification. The results from the present study demonstrate that saliva SERS analysis used in conjunction with PCA-LDA diagnostic algorithms possesses a promising clinical application for the non-invasive detection of NPC.

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Long-Term Outcomes of Early-Stage Nasopharyngeal Carcinoma Patients Treated With Intensity-Modulated Radiotherapy Alone

Cited by 190 publications

References 26 publications

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

miRNA and nasopharyngeal carcinoma

Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy

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