Long term outcomes of cemented endoprosthetic reconstruction for periarticular tumors of the distal femur

Houdek, Matthew T.; Wagner, Eric R.; Wilke, Benjamin K.; Wyles, Cody C.; Taunton, Michael J.; Sim, Franklin H.

doi:10.1016/j.knee.2015.08.010

Cited by 55 publications

(56 citation statements)

References 34 publications

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“…Amputations can be needed as secondary surgical treatment after a limb‐sparing tumor resection and reconstruction with a tumor prosthesis, and common indications for amputations are local tumor relapse or recurrent infections. Houdek et al analyzed long‐term results of cemented distal femur tumor prostheses. They found an amputation risk of 7%, with tumor relapse and recurrent infections as the most common indications for amputation and an overall limb survival for 5 and 20 years was 89% and 84%, respectively .…”

Section: Discussionmentioning

confidence: 99%

“…Houdek et al analyzed long‐term results of cemented distal femur tumor prostheses. They found an amputation risk of 7%, with tumor relapse and recurrent infections as the most common indications for amputation and an overall limb survival for 5 and 20 years was 89% and 84%, respectively . Zeegen et al found an equal distribution between local relapse and recurrent infection as amputation indication.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long‐term results of the Global Modular Replacement System tumor prosthesis for reconstruction after limb‐sparing bone resections in orthopedic oncologic conditions: Results from a national cohort

Yilmaz

Sørensen

Saebye

et al. 2019

Journal of Surgical Oncology

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Background and Objectives We investigated implant revision, implant failure, and amputation risk after limb‐sparing bone tumor surgery using the Global Modular Replacement System (GMRS) tumor prosthesis in patients suffering from bone sarcomas (BS), giant cell tumors (GCT), or metastatic bone disease (MBD). Material and Methods A retrospective study of a nationwide consecutive cohort (n = 119, 47 [12‐81] years, M/F = 65/54) having limb‐sparing surgery and reconstruction using the GMRS tumor prosthesis due to bone tumors (BS/GCT/MBD = 70/8/41) from 2005 to 2013. Anatomical locations were as followed: distal femur (n = 49), proximal femur (n = 41), proximal tibia (n = 26), or total femur (n = 3). Kaplan‐Meier survival analysis and competing risk analysis with death as a competing risk were used for statistical analysis. Results For BS and GCT patients, 5‐year patient survival was 72% (95% confidence interval [CI]: 59‐85%) and for MBD 33% (95% CI: 19‐48%). Thirty‐two patients underwent revision surgery (5‐year revision incidence 14%; 95% CI: 8‐21%). Twelve patients had revision of bone‐anchored parts (implant failure) with a 5‐year revision incidence 6% (95% CI: 2‐10%). Ten amputations were performed due to local relapse (n = 9) or recurrent infections (n = 1) with a 5‐year incidence of amputation: 8% (95% CI: 3‐13%). Conclusions We identified a low risk of revision and amputation when using the GMRS tumor prosthesis for limb‐sparing bone tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long‐term results of the Global Modular Replacement System tumor prosthesis for reconstruction after limb‐sparing bone resections in orthopedic oncologic conditions: Results from a national cohort

Yilmaz

Sørensen

Saebye

et al. 2019

Journal of Surgical Oncology

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“…TKA may warrant more specialized care due to the risks of arthroplasty complications [10]. Reoperation for any cause, post-operative infection, or revision arthroplasty may lead to an increased risk of knee arthroplasty failure performed during an oncological process [11]. …”

Section: Discussionmentioning

confidence: 99%

“…However, our patients did not have any obvious tumor recurrence in the local position, which may be due to the benign lesion of TIO disease and unique tumor position. Houdek et al [11] concluded that malignant tumors would increase the risk of revision, re-operation and post-operative infection following endoprosthetic reconstruction of the knee, while benign tumors would decrease it.…”

Section: Discussionmentioning

confidence: 99%

Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up

Zhu

Bian

et al. 2017

PLoS ONE

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BackgroundTumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the metaphysis remain largely uninvestigated.MethodsA retrospective study of sixteen patients was undertaken to evaluate treatment of tumors with joint arthroplasty and tumor resection. The bone metabolism index, hip/knee joint function, arthroplasty complications and symptoms were followed up for at least 12 months in each patient.ResultsAll patients presented with neoplasms situated in the articular surface of the metaphysis, with 13 cases undergoing hip arthroplasty and 3 undergoing knee arthroplasty. Treatment of the tumors with joint arthroplasty and tumor resection significantly and rapidly ameliorate bone metabolism indexes in patients with TIO (p<0.01), with no identified tumor recurrence. The joint function evaluation score was improved in 15 patients (93.75%). Complications in these patients included post-operative pain, joint squeaking and secondary hyperparathyroidism.ConclusionsJoint arthroplasty that includes tumor-expanding resection appears to be a safe and appropriate method for the treatment of TIO patients with a neoplasm located in the metaphysis proximal to the articular surface.Level of evidenceTherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

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“…Nevertheless, limb salvage surgery is usually successful, but patients should be properly counselled and should prepare for aggressive post-surgical rehabilitation in an effort to prevent arthrofibrosis. 23 Tibial resections and reconstructions have a much more unpredictable result and are prone to a higher complication rate. Proximal tibial resections require complex reconstruction of the extensor mechanism of the knee which is prone to failure.…”

Section: Lower Extremity Sarcomasmentioning

confidence: 99%

<p>Rehabilitation to Improve the Function and Quality of Life of Soft Tissue and Bony Sarcoma Patients</p>

Andrews¹,

Siegel²,

Smith³

2020

PROM

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Sarcomas are bone and soft tissue tumors that can have significant effects on patient function and quality of life. Like most malignancies, treatment includes a combination of chemotherapy, radiation, and surgical resection, all of which also carry risks and long-term effects. A multidisciplinary rehabilitation plan can help minimize symptoms and sequelae which negatively affect the patient function and quality of life, including pain, chemotherapy-induced peripheral neuropathy, radiation fibrosis, activity restrictions following surgical excision, amputation, bowel and bladder dysfunction, and lymphedema. Patients should be evaluated by a rehabilitation specialist at any point during their diagnosis, treatment, and survivorship phase to determine appropriate interventions to minimize the impact of sarcomas and their treatment on patient function and quality of life.

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Long term outcomes of cemented endoprosthetic reconstruction for periarticular tumors of the distal femur

Cited by 55 publications

References 34 publications

Long‐term results of the Global Modular Replacement System tumor prosthesis for reconstruction after limb‐sparing bone resections in orthopedic oncologic conditions: Results from a national cohort

Long‐term results of the Global Modular Replacement System tumor prosthesis for reconstruction after limb‐sparing bone resections in orthopedic oncologic conditions: Results from a national cohort

Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up

<p>Rehabilitation to Improve the Function and Quality of Life of Soft Tissue and Bony Sarcoma Patients</p>

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