Long-Term Outcomes of a Large Cohort of Patients with Eales’ Disease

Biswas, Jyotirmay; Reesha, K R; Pal, Bikramjit P; Gondhale, Harshal; Sitaula, Ranju Kharel

doi:10.1080/09273948.2017.1298817

Cited by 26 publications

(27 citation statements)

References 12 publications

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“…Eales' disease is a condition characterized by occlusive vasculitis and development of retinal neovascularization. Biswas et al have been instrumental in providing an update on the current understanding and etiopathogenesis of this condition [61,62]. Eales' disease is presently thought to be due to hypersensitivity reaction to tubercular proteins.…”

Section: Presumed Tubercular Retinal Vasculitismentioning

confidence: 99%

Infectious uveitis: an Asian perspective

Agarwal

Aggarwal

Gupta

2018

Eye

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Several intraocular infections can present with protean manifestations posing major diagnostic and management challenges. Infections such as tuberculosis, dengue and chikungunya fever have continued to remain major endemic diseases that are associated with uveitis in the Asia Pacific region. These entities often require a high index of clinical suspicion and laboratory analysis including assays of ocular fluids and/or tissues for confirmation of the diagnosis. Infectious uveitis caused by tuberculosis, dengue and chikungunya can present with characteristic clinical features and imaging findings on ancillary investigations; that may provide clue to the early diagnosis. Use of modern imaging modalities such as enhanceddepth imaging optical coherence tomography, optical coherence tomography angiography and ultra-wide field fundus photography greatly aid in the evaluation of these conditions. In the current review, we have discussed the epidemiology, clinical phenotypes, imaging characteristics, diagnosis and management of uveitis caused by tuberculosis, dengue and chikungunya.

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Section: Presumed Tubercular Retinal Vasculitismentioning

confidence: 99%

Infectious uveitis: an Asian perspective

Agarwal

Aggarwal

Gupta

2018

Eye

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“… 2 Active periphlebitis may be accompanied by anterior uveitis, posterior uveitis, and pars planitis. 1 , 3 Patients usually present with recurrent VH and involvement is generally bilateral. 3 Although defined as an idiopathic disease, it may be associated with Mycobacterium tuberculosis and hypersensitivity to tubercular antigen.…”

Section: Introductionmentioning

confidence: 99%

“…Systemic steroid therapy is effective in controlling the active phase of Eales’ disease. 3 Intravitreal steroids are useful in the treatment of periphlebitis and cystoid macular edema. 6 , 7 Performing early retinal photocoagulation on non-perfused areas has a positive effect on visual outcomes.…”

Section: Introductionmentioning

confidence: 99%

Vitrectomy Due to Vitreous Hemorrhage and Tractional Retinal Detachment Secondary to Eales’ Disease

Ersöz¹,

Hocaoğlu²,

Muslubaş³

et al. 2021

tjo

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Objectives: To investigate visual and anatomical outcomes of vitreoretinal surgeries in patients with Eales’ disease. Materials and Methods: In this retrospective study, 22 eyes of 21 patients with vitreous hemorrhage (VH) or tractional retinal detachment (TRD) secondary to Eales’ disease who underwent vitreoretinal surgery between January 1997 and December 2015 and had at least 1 year of follow-up were included. Results: The mean best corrected visual acuity (BCVA) was significantly higher at final visit (0.6±0.9 logMAR) than the preoperative values (1.8±1.1 logMAR) (p<0.001). After surgery, BCVA was stable in 4 eyes (18.2%), increased in 16 eyes (72.7%), and decreased in 2 eyes (9.1%). Although the mean BCVA was better in the VH group (0.3±0.34 logMAR) than the TRD group (0.9±1.1 logMAR), the difference was not statistically significant (p=0.1). Multivariable linear regression analyses revealed that final BCVA was negatively associated with preoperative or postoperative proliferative vitreoretinopathy grade C (PVR-C), preoperative retinal detachment involving the macula, postoperative neovascular glaucoma, and long preoperative duration of disease, and positively associated with preoperative BCVA. Final BCVA was not associated with preoperative retinal and disc neovascularization, rubeosis iridis, total posterior hyaloid detachment, preoperative retinal laser photocoagulation, indication of surgery, diameter of sclerotomy (20 or 23 gauge), preoperative lens status, preoperative or postoperative epimacular membrane, peroperative iatrogenic retinal breaks, postoperative hypotony, cystoid macular edema, and new or recurrent retinal detachment. The primary anatomic success rate was 81.8% and the final anatomic success rate was 90.9%. Conclusion: In Eales’ disease, good visual results can be obtained with vitreoretinal surgery if the detachment area does not involve the macula and PVR-C does not develop pre- or postoperatively.

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“…Also, late presentation was attributed to poor final outcome of disease. 5 In a separate study, evaluation of vitreous fluid of patients of ED revealed increased expression of Vascular Endothelial Growth Factor (VEGF), highlighting the possible role of intravitreal anti-VEGF in treatment and managing progression of ED. 6 Different case reports have reported efficacy of intravitreal anti VEGF injections in management of ED.…”

Section: Introductionmentioning

confidence: 99%

Role of intravitreal bevacizumab in management of Eale’s Disease

Mehboob¹,

Tahir²,

Batool³

2018

Pak J Med Sci

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Objective:To investigate the role of Intravitreal Bevacizumab (IVB), in preventing vitreo-retinal complications in patients of Eale’s Disease (ED).Methods:This randomized control trial was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from May 2015 to December 2016. A total of 52 eyes of 26 patients, diagnosed with stage I or II of ED were randomly divided in two groups. Group A received monthly injections of IVB for 3 months, with steroids and laser photocoagulation. Group B received only steroids and laser treatment. Patients were followed for three months, and were analyzed for different clinical parameters.Results:Mean age of study population was 28.5±2.64 years. Difference in frequency of patients requiring PPV and showing regression in neovascularization was statistically significant between both groups (p=0.005 for both). However, difference in frequency of patients showing progression in stage of ED, regression of vasculitis and best corrected visual acuity at 12 weeks between two groups was not statistically significant (p= 0.012, 0.579, 0.046 respectively).Conclusion:Intravitreal Bevacizumab injection, given monthly in patients of ED results in significantly more regression in neovascularization, and less requirement for PPV, as compared to those receiving standard steroids and laser photocoagulation treatment.

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Long-Term Outcomes of a Large Cohort of Patients with Eales’ Disease

Abstract: Eales' disease is a bilateral recurrent retinal vasculitis disorder and timely treatment with steroid and/or laser photocoagulation result in better visual outcomes.

Cited by 26 publications

References 12 publications

Infectious uveitis: an Asian perspective

Infectious uveitis: an Asian perspective

Vitrectomy Due to Vitreous Hemorrhage and Tractional Retinal Detachment Secondary to Eales’ Disease

Role of intravitreal bevacizumab in management of Eale’s Disease

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