Long-Term Outcomes in Critically Ill Septic Patients Who Survived Cardiopulmonary Resuscitation*

Abstract

The long-term outcome was worse in ICU survivors of sepsis who received in-hospital cardiopulmonary resuscitation than in those who did not, but this increased risk of mortality diminished at 2 years after discharge.

New-Onset Heart Failure and Mortality in Hospital Survivors of Sepsis-Related Left Ventricular Dysfunction

“…(7, 8) As heart disease continues to occupy the largest share of United States health care spending, there is a growing need to understand the long-term cardiovascular disease burden in sepsis survivors. (7–10)…”

Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest: Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated the Vasopressin–Steroids–Epinephrine Combination Versus Epinephrine Alone

“…Additional IPDRA limitations include a partly retrospective data collection (i.e., antibiogram data), and an Bas-treated^rather than an Bas-randomized^primary data analysis. The latter eliminates group cross-contamination due to protocol violation(s), but may result in baseline, betweengroup imbalances in potentially Beffect-modifying^patient characteristics (Table 1 and Table S1) [38]. In fact, and especially as regards the substantial imbalances in cardiac arrest causes (Table 1 and Table S1), one could reasonably argue that the IPDRA (and ITT) groups were fundamentally different.…”

The Promise of Personalized Care in the Intensive Care Unit

“…In a recent national cohort study analysis of long-term survivors of sepsis following cardiopulmonary resuscitation, both male sex and advancing age were significant predictors of mortality. 6 Biologically relevant variables may direct personalized interventions at the bedside in the same way that genetic/genomic data have begun to direct pharmacologic interventions. Research to expand our knowledge about personalized care will enable critical care clinicians to align patients who are most likely to benefit from receiving an intervention to delivery of that intervention at a particular point in time or in a particular way.…”