Long-term outcomes for adult craniopharyngioma following radiation therapy

Masson-Côté, Laurence; Masucci, Giuseppina Laura; Atenafu, Eshetu G.; Millar, Barbara‐Ann; Cusimano, Michael D.; Croul, Sidney; Mason, Warren P.; Laperrière, Normand; Sahgal, Arjun

doi:10.3109/0284186x.2012.685525

Cited by 28 publications

(13 citation statements)

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“…Previous analysis of 40 patients at our institution resulted in excellent local control of 100% and overall survival of 89% after 10 years [ 12 ]. Similar findings were reported in other studies [ 25 , 26 ]. Since life expectancy for patients with craniopharyngioma after receiving treatment is barely limited the reduction of long term treatment-related side effects is of highest relevance.…”

Section: Discussionsupporting

confidence: 93%

Long term results after fractionated stereotactic radiotherapy (FSRT) in patients with craniopharyngioma: maximal tumor control with minimal side effects

et al. 2014

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PurposeThere are already numerous reports about high local control rates in patients with craniopharyngioma but there are only few studies with follow up times of more than 10 years. This study is an analysis of long term control, tumor response and side effects after fractionated stereotactic radiotherapy (FSRT) for patients with craniopharyngioma.Patients and methods55 patients who were treated with FSRT for craniopharyngioma were analyzed. Median age was 37 years (range 6–70 years), among them eight children < 18 years. Radiotherapy (RT) was indicated for progressive disease after neurosurgical resection or postoperatively after repeated resection or partial resection. A median dose of 52.2 Gy (50 – 57.6 Gy) was applied with typical dose per fraction of 1.8 Gy five times per week. The regular follow up examinations comprised in addition to contrast enhanced MRI scans thorough physical examinations and clinical evaluation.ResultsDuring median follow up of 128 months (2 – 276 months) local control rate was 95.3% after 5 years, 92.1% after 10 years and 88.1% after 20 years. Overall survival after 10 years was 83.3% and after 20 years 67.8% whereby none of the deaths were directly attributed to craniopharyngioma. Overall treatment was tolerated well with almost no severe acute or chronic side effects. One patient developed complete anosmia, another one’s initially impaired vision deteriorated further. In 83.6% of the cases with radiological follow up a regression of irradiated tumor residues was monitored, in 7 cases complete response was achieved. 44 patients presented themselves initially with endocrinologic dysfunction none of them showed signs of further deterioration during follow up. No secondary malignancies were observed.ConclusionLong term results for patients with craniopharyngioma after stereotactic radiotherapy are with respect to low treatment related side effects as well as to local control and overall survival excellent.

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Section: Discussionsupporting

confidence: 93%

Long term results after fractionated stereotactic radiotherapy (FSRT) in patients with craniopharyngioma: maximal tumor control with minimal side effects

et al. 2014

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“…With respect to endocrine outcomes, new endocrinopathies have been observed in 6.1-90% of the cases after any surgical and/or radiation therapy for craniopharyngiomas (Table 4) (6,12,16,18,21,24,33,40). Accurate rates for developing new endocrinopathy have not been reported in patients treated with neuroendoscopy followed by radiotherapy.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 98%

Neuroendoscopy Followed by Radiotherapy in Cystic Craniopharyngiomas—a Long-Term Follow-Up

et al. 2015

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“…Surgery is the initial treatment modality for most patients with a craniopharyngioma; complete resection is associated with a 5-year tumor growth control of 70-90% in adult and pediatric series, although aggressive surgical management is associated with a high risk of complications [110][111][112][113][114], particularly relating to hypothalamic damage. Limited surgery followed by radiation is an alternative to aggressive surgical treatments associated with comparable outcome and lower risk of long term sequelae [112,[115][116][117][118][119]. The GTV is defined as the visible lesion on post-contrast T1-weighted and T2-weighted MRI sequences with a 1-2 mm slice thickness to ensure the accuracy of target delineation.…”

Section: Craniopharyngiomamentioning

confidence: 99%