Long-term outcomes following resection of retroperitoneal recurrence of colorectal cancer

Razik, Roshan; Zih, Francis S.W.; Haase, Erika; Mathieson, Alister J. M.; Sandhu, Lakhbir; Lindsay, Thomas F.; Smith, Andy; Swallow, Carol J.

doi:10.1016/j.ejso.2013.10.008

Cited by 13 publications

(17 citation statements)

References 22 publications

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“…5b ). Over time, there is a significant difference in the area of the spheroids and at the end of 72 hours, the CT26 spheroids exposed to IB (3.25 × 10 5 μm 2 ) are 25% smaller than the control spheroids (4.34 × 10 5 μm 2 ) and the HCT116 spheroids exposed to IB (1.60 × 10 5 μm 2 ) are 44% smaller than the control (2.85 × 10 5 μm 2 ). The inhibitory effect of higher concentrations of IB (0.4 OD and 0.8 OD) on CT26 and HCT116 spheroids, shown in Supplementary Fig.…”

Section: Resultsmentioning

confidence: 96%

“…However, existing forms of cancer treatment are limited in their efficacy. Surgery is the first line of treatment for colorectal cancers detected in their early stage, but it is ineffective against the advanced stages of cancer 2 3 . The tumor microenvironment plays a key role in limiting the efficacy of other conventional forms of cancer treatment, such as chemotherapy and radiation therapy (RT).…”

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confidence: 99%

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Effect of Heat-Inactivated Clostridium sporogenes and Its Conditioned Media on 3-Dimensional Colorectal Cancer Cell Models

Bhave

Hassanbhai

Anand

et al. 2015

Sci Rep

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Traditional cancer treatments, such as chemotherapy and radiation therapy continue to have limited efficacy due to tumor hypoxia. While bacterial cancer therapy has the potential to overcome this problem, it comes with the risk of toxicity and infection. To circumvent these issues, this paper investigates the anti-tumor effects of non-viable bacterial derivatives of Clostridium sporogenes. These non-viable derivatives are heat-inactivated C. sporogenes bacteria (IB) and the secreted bacterial proteins in culture media, known as conditioned media (CM). In this project, the effects of IB and CM on CT26 and HCT116 colorectal cancer cells were examined on a 2-Dimensional (2D) and 3-Dimensional (3D) platform. IB significantly inhibited cell proliferation of CT26 to 6.3% of the control in 72 hours for the 2D monolayer culture. In the 3D spheroid culture, cell proliferation of HCT116 spheroids notably dropped to 26.2%. Similarly the CM also remarkably reduced the cell-proliferation of the CT26 cells to 2.4% and 20% in the 2D and 3D models, respectively. Interestingly the effect of boiled conditioned media (BCM) on the cells in the 3D model was less inhibitory than that of CM. Thus, the inhibitive effect of inactivated C. sporogenes and its conditioned media on colorectal cancer cells is established.

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Section: Resultsmentioning

confidence: 96%

mentioning

confidence: 99%

Effect of Heat-Inactivated Clostridium sporogenes and Its Conditioned Media on 3-Dimensional Colorectal Cancer Cell Models

Bhave

Hassanbhai

Anand

et al. 2015

Sci Rep

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“…Firstly, it is important to note that while the survival rates of surgical treatments are considerably high [5][6][7][8][9], the overall recurrence rates are significant too. This makes it necessary for patients to undergo surgical procedures more than once [10]. Secondly, the surgical form of treatment cannot be used in the later stages of cancer, so its effectiveness is contingent on early diagnosis of the disease.…”

Section: Surgerymentioning

confidence: 99%

“…10 shows the effect of IB on A498 spheroids. IB treatment did not cause a decrease in the viability of these spheroids (Figure 3.10 (a)).…”

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confidence: 99%

“…10 shows that the cells on the periphery of the control CT26 spheroids were circular in shape, packed together with tight cell contacts and thickly covered by the extracellular matrix (ECM). On the other hand, on the periphery of the spheroids exposed to IB, the cells were elongated, loosely packed with thinner ECM.The morphology of IB-exposed spheroid is deformed in contrast to the spherical morphology of control spheroid.…”

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confidence: 99%

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Bacteria-mediated anti-cancer therapy

Bhave¹

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Outcomes of metachronous para-aortic lymphadenectomy in colorectal cancer: a systematic review of the literature

Onafowokan,

Redfern,

Patel

et al. 2023

Langenbecks Arch Surg

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Introduction and aim Para-aortic lymph node metastasis associated with colorectal cancer is a very rare occurrence, but at the same time an important predictor of survival. Despite its importance, there is still no gold standard management strategy, particularly for lymph nodes detected during follow-up, after resection of the primary tumour. Therefore, this review was undertaken to examine the evidence available on the surgical and non-surgical management of metachronous para-aortic lymph node metastasis (m-PALNM) in colorectal cancer treatment. Methods This is a systematic review using the patient, intervention, comparison, outcome and study strategy. The literature search was undertaken using Cochrane, MEDLINE, EMBASE and PubMed databases with the following MeSH terms: lymph node excision, para-aortic lymph node, metastasis, metachronous and colorectal neoplasms. Results Five original papers met the study criteria including 188 patients in total (55.3% male, 44.7% female). Surgical resection of the m-PALND was the management of choice in 64% of patients. Reporting styles on survival outcomes were heterogeneous. However, patients undergoing surgical management for m-PALNM had longer disease-free survival and overall survival rates. Conclusion There is significant paucity in the evidence available on the management of m-PALNM. However, the evidence reported by this review suggests that surgical management should be considered whenever possible, with the aim of prolonging survival. Future randomised trials are needed in order to provide further high-level evidence on m-PALNM management.

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Long-term outcomes following resection of retroperitoneal recurrence of colorectal cancer

Cited by 13 publications

References 22 publications

Effect of Heat-Inactivated Clostridium sporogenes and Its Conditioned Media on 3-Dimensional Colorectal Cancer Cell Models

Effect of Heat-Inactivated Clostridium sporogenes and Its Conditioned Media on 3-Dimensional Colorectal Cancer Cell Models

Bacteria-mediated anti-cancer therapy

Outcomes of metachronous para-aortic lymphadenectomy in colorectal cancer: a systematic review of the literature

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