Long-Term Outcomes Following Bladder Augmentation in Children with Neurogenic Bladder

Keenan, Alison; Whittam, Benjamin; Misseri, Rosalie; Cain, Mark P.

doi:10.1007/s11884-014-0268-1

Cited by 4 publications

(6 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Orally absorbed vitamin B 12 is bound to the intrinsic factor secreted by the parietal cells within the stomach. The vitamin B 12 intrinsic factor complex binds to the vitamin B 12 receptor protein within the ileal epithelial cells . Vitamin B 12 deficiency has been reported to occur after any urological reconstruction where a segment of ileum has been used; that is, ileal augmentations, ileal neobladders, ileocecal reservoirs and ileal conduits .…”

Section: Non‐lethal Complications After Bladder Augmentationmentioning

confidence: 99%

“…The vitamin B 12 intrinsic factor complex binds to the vitamin B 12 receptor protein within the ileal epithelial cells. 56,57 Vitamin B 12 deficiency has been reported to occur after any urological reconstruction where a segment of ileum has been used; that is, ileal augmentations, ileal neobladders, ileocecal reservoirs and ileal conduits. 56 Classically, low serum vitamin B 12 levels will begin to appear 3-5 years post-surgical reconstruction; however, because of the high levels of vitamin B 12 stored in the liver and skeletal muscles, it might take up to 15 years to manifest.…”

Section: Vitamin B 12 Deficiencymentioning

confidence: 99%

“…56,57 Vitamin B 12 deficiency has been reported to occur after any urological reconstruction where a segment of ileum has been used; that is, ileal augmentations, ileal neobladders, ileocecal reservoirs and ileal conduits. 56 Classically, low serum vitamin B 12 levels will begin to appear 3-5 years post-surgical reconstruction; however, because of the high levels of vitamin B 12 stored in the liver and skeletal muscles, it might take up to 15 years to manifest. 56,57 In our experience, we have found that 8% (12/153) of patients where the ileum or the ileal-cecal junction was used for urological reconstruction will develop low vitamin B 12 levels by the 15th post-augment year.…”

Section: Vitamin B 12 Deficiencymentioning

confidence: 99%

“…56 Classically, low serum vitamin B 12 levels will begin to appear 3-5 years post-surgical reconstruction; however, because of the high levels of vitamin B 12 stored in the liver and skeletal muscles, it might take up to 15 years to manifest. 56,57 In our experience, we have found that 8% (12/153) of patients where the ileum or the ileal-cecal junction was used for urological reconstruction will develop low vitamin B 12 levels by the 15th post-augment year. Approximately three-quarters (9/12) of our patients are able to correct the defect by increasing the ingestion of oral vitamin B 12 or multivitamins.…”

Section: Vitamin B 12 Deficiencymentioning

confidence: 99%

“…Long‐term follow up of this patient population is mandatory to verify that oral supplementation remains successful. If not, parenteral treatment will become necessary . It is noteworthy that failure to identify or correct this vitamin deficiency might be associated with peripheral neuropathy, dementia, accelerated atherosclerosis as a result of elevated levels of homocysteine and megaloblastic anemia …”

Section: Non‐lethal Complications After Bladder Augmentationmentioning

confidence: 99%

See 4 more Smart Citations

Lessons learned from the management of adults who have undergone augmentation for spina bifida and bladder exstrophy: Incidence and management of the non‐lethal complications of bladder augmentation

Husmann

2017

Int J of Urology

View full text Add to dashboard Cite

The present review provides clinical insights and makes recommendations regarding patient management garnered by the long-term follow up of patients undergoing enteric bladder augmentation for the management of congenital anomalies. A prospectively maintained database on 385 patients that have experienced an enteric bladder augmentation, using either the ileum or colon, was reviewed. Evaluations included methods used to prevent bladder calculi formation and recurrence, the incidence and etiology of renal calculi development, the incidence and treatment of vitamin B 12 deficiency, and the complications and need for surgical revisions for continent catheterizable stomas. A significantly increased risk for continent catheterizable stomal complications occurred after Monti-Yang tube formation, 70% (21/ 30 patients), compared with appendicovesicostomy, 41% (27/66 patients), P = 0.008. Both procedures had significantly more complications than continent catheterizable stomas using tapered ileum with a reinforced ileal-cecal valve, 21% (13/63 patients), P < 0.0001 and P < 0.013, respectively. Approximately 50% of the patient population developed a body mass index ≥30 during adulthood. The onset of obesity resulted in significantly more complications developing in patients with a Monti-Yang tube (87%; 13/ 15 patients) or appendicovesicostomy (55%; 18/33 patients) compared with a tapered ileum with a reinforced ileal-cecal valve (27%, 8/30 patients), P < 0.00015 and P < 0.025, respectively, with a median follow-up interval of 16 years, range 10-25 years. Long-term follow-up evaluations on patients undergoing an enteric bladder augmentation are necessary to prevent the long-term sequela of this procedure. The key to improving patient prognosis is the nutritional management of the patient as they mature, especially if a continent abdominal stoma is going to be carried out.

show abstract

Section: Non‐lethal Complications After Bladder Augmentationmentioning

confidence: 99%