Long-Term Outcomes Comparison Between Surgical and Percutaneous Coronary Revascularization in Patients With Multivessel Coronary Disease or Left Main Disease: A Systematic Review and Study Level Meta-Analysis of Randomized Trials

Formica, Francesco; Gallingani, Alan; Tuttolomondo, Domenico; Hernández-Vaquero, Daniel; Singh, Gurmeet; Pattuzzi, Claudia; Maestri, Francesco; Niccoli, Giampaolo; Ceccato, Evelina; Lorusso, Roberto; Nicolini, Francesco

doi:10.1016/j.cpcardiol.2023.101699

Current Problems in Cardiology

2023

DOI: 10.1016/j.cpcardiol.2023.101699

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Long-Term Outcomes Comparison Between Surgical and Percutaneous Coronary Revascularization in Patients With Multivessel Coronary Disease or Left Main Disease: A Systematic Review and Study Level Meta-Analysis of Randomized Trials

Francesco Formica

Alan Gallingani

Domenico Tuttolomondo

et al.

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2024

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Cited by 6 publications

(1 citation statement)

References 24 publications

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“…3 Moreover, patients with atherosclerosis undergoing percutaneous coronary intervention, coronary artery bypass grafting, or endarterectomy may later encounter complications, including in-stent restenosis or lumen thrombosis. 4 Hence, there is an active pursuit of safe and effective therapeutic strategies for atherosclerotic disease.…”

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CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis

Lv,

Wang,

Zhang

et al. 2024

Circulation Research

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BACKGROUND: Atherosclerosis is a globally prevalent chronic inflammatory disease with high morbidity and mortality. The development of atherosclerotic lesions is determined by macrophages. This study aimed to investigate the specific role of myeloid-derived CD147 in atherosclerosis and its translational significance. METHODS AND RESULTS: We generated mice with a myeloid-specific knockout of CD147 and mice with restricted CD147 overexpression, both in an apoE-deficient (ApoE –/– ) background. Here, the myeloid-specific deletion of CD147 ameliorated atherosclerosis and inflammation. Consistent with our in vivo data, macrophages isolated from myeloid-specific CD147 knockout mice exhibited a phenotype shift from proinflammatory to anti-inflammatory macrophage polarization in response to lipopolysaccharide/IFN (interferon)-γ. These macrophages demonstrated a weakened proinflammatory macrophage phenotype, characterized by reduced production of NO and reactive nitrogen species derived from iNOS (inducible NO synthase). Mechanistically, the TRAF6 (tumor necrosis factor receptor–associated factor 6)-IKK (inhibitor of κB kinase)-IRF5 (IFN regulatory factor 5) signaling pathway was essential for the effect of CD147 on proinflammatory responses. Consistent with the reduced size of the necrotic core, myeloid-specific CD147 deficiency diminished the susceptibility of iNOS-mediated late apoptosis, accompanied by enhanced efferocytotic capacity mediated by increased secretion of GAS6 (growth arrest–specific 6) in proinflammatory macrophages. These findings were consistent in a mouse model with myeloid-restricted overexpression of CD147. Furthermore, we developed a new atherosclerosis model in ApoE –/– mice with humanized CD147 transgenic expression and demonstrated that the administration of an anti-human CD147 antibody effectively suppressed atherosclerosis by targeting inflammation and efferocytosis. CONCLUSIONS: Myeloid CD147 plays a crucial role in the growth of plaques by promoting inflammation in a TRAF6-IKK-IRF5–dependent manner and inhibiting efferocytosis by suppressing GAS6 during proinflammatory conditions. Consequently, the use of anti-human CD147 antibodies presents a complementary therapeutic approach to the existing lipid-lowering strategies for treating atherosclerotic diseases.

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CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis

Lv,

Wang,

Zhang

et al. 2024

Circulation Research

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Results beyond 5-years of surgery or percutaneous approach in severe coronary disease. Reconstructed time-to-event meta-analysis of randomized trials

Formica,

Hernandez-Vaquero,

Tuttolomondo

et al. 2024

Revista Española de Cardiología (English Edition)

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Coronary artery bypass, percutaneous coronary intervention, and mortality: a reflection on methods

Elosua

2024

Revista Española de Cardiología (English Edition)

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Long-Term Outcomes Comparison Between Surgical and Percutaneous Coronary Revascularization in Patients With Multivessel Coronary Disease or Left Main Disease: A Systematic Review and Study Level Meta-Analysis of Randomized Trials

Cited by 6 publications

References 24 publications

CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis

CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis

Results beyond 5-years of surgery or percutaneous approach in severe coronary disease. Reconstructed time-to-event meta-analysis of randomized trials

Coronary artery bypass, percutaneous coronary intervention, and mortality: a reflection on methods

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