Long-term outcomes and predictors of disabling disease in a population-based cohort of patients with incident Crohn's disease diagnosed between 1994 and 1997

Rabilloud, M.-L.; Bajeux, Emma; Siproudhis, L.; Hamonic, Stéphanie; Pagenault, Maël; Brochard, Charlène; GERFAUD, Agathe; Dabadie, A.; Viel, Jean‐François; Tron, Isabelle; Robaszkiewicz, Michel; Bretagne, Jean–François; Bouguen, Guillaume

doi:10.1016/j.clinre.2022.101974

Cited by 1 publication

(2 citation statements)

References 33 publications

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“…Follow-up will be for a minimum of 4 years: since participants were recruited to METRIC over 30 months, this corresponds to an average follow-up of approximately 5.5 years. This provides sufficient time for clinically relevant complications of CD to manifest 35–37…”

Section: Methodsmentioning

confidence: 99%

“…This provides sufficient time for clinically relevant complications of CD to manifest. [35][36][37] Primary definition of disabling disease The primary definition of disabling disease will be a modified version of that described by Beaugerie et al 38 The original definition has been modified to clarify some of the symptoms and to permit the use of disease-modifying therapy, since this has become a common preventative measure in modern practice. Disabling disease will therefore be defined as any of the following: ► Hospitalisation after CD diagnosis for flare or disease complication, as judged by the treating clinician.…”

Section: Assessment Of Disease Severity At Follow-up Time Point Of Fo...mentioning

confidence: 99%

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METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study

et al. 2022

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IntroductionCrohn’s disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeutics are effective but associated with certain side-effects and relatively expensive. There is therefore an urgent need for robust methods to predict which newly diagnosed patients will develop disabling disease, to identify patients who are most likely to benefit from early, advanced therapies. We aim to determine if magnetic resonance enterography (MRE) features at diagnosis improve prediction of disabling CD within 5 years of diagnosis.Methods and analysisWe describe the protocol for a multicentre, non-randomised, single-arm, prospective study of adult patients with newly diagnosed CD. We will use patients already recruited to the METRIC study and extend their clinical follow-up, as well as a separate group of newly diagnosed patients who were not part of the METRIC trial (MRE within 3 months of diagnosis), to ensure an adequate sample size. Follow-up will extend for at least 4 years. The primary outcome is to evaluate the comparative predictive ability of prognostic models incorporating MRE severity scores (Magnetic resonance Enterography Global Score (MEGS), simplified MAgnetic Resonance Index of Activity (sMaRIA) and Lémann Index) versus models using standard characteristics alone to predict disabling CD (modified Beaugerie definition) within 5 years of new diagnosis.Ethics and disseminationThis study protocol achieved National Health Service Research Ethics Committee (NHS REC), London—Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications.Trial registration numberISRCTN76899103.

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Section: Methodsmentioning

confidence: 99%

Section: Assessment Of Disease Severity At Follow-up Time Point Of Fo...mentioning

confidence: 99%

METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study

et al. 2022

View full text Add to dashboard Cite

show abstract

Long-term outcomes and predictors of disabling disease in a population-based cohort of patients with incident Crohn's disease diagnosed between 1994 and 1997

Cited by 1 publication

References 33 publications

METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study

METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study

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