Long-term outcomes and late adverse effects of a prospective study on proton radiotherapy for patients with low-grade glioma

Dose distribution of the brain tissue associated with cognitive functions in high-grade glioma patients

“…reported the minimum dose to the corpus callosum and the volume of right-sided subcortical white matter exposed to total doses of 30 or 40 Gy could predict the attention/processing speed decrease observed 6 months after radiotherapy [25]. Another prospective study performed on 20 low-grade glioma patients treated with protontherapy showed no significant cognitive decline with a median follow-up of 36 months regarding the neuropsychological assessments [26]. Tabrizi et al reported no statistically significant relationship between the risk of cognitive impairment following brain radiotherapy and the dose distribution to the healthy tissues, namely to the hippocampi.…”

Proton therapy for selected low grade glioma patients in the Netherlands

“…Although the effectiveness of photons and protons has not been directly compared, the available data do not suggest inferior outcome of protons on tumour control [15][16][17]. The circumstantial low to intermediate dose (≤ 30 Gy RBE ) in a large volume of the brain, typical of photon-based treatment plans, is not considered to have a noteworthy contribution to tumour control in glioma [18,19].…”

Who Will Benefit from Charged-Particle Therapy?

“…Long-term outcome data showing favorable toxic profile of the PBT for the treatment of pediatric central nervous system cancer such as medulloblastoma has been published [12][13][14]. Furthermore, the relationship between PBT and secondary cancer has been clarified.…”