Long-Term Outcomes After Total Pancreatectomy and Islet Cell Autotransplantation

Abstract

This represents one of the largest series examining long-term outcomes after TPIAT. This operation produces durable pain relief and improvement in QOL parameters. Insulin independence rates decline over time, but most patients maintain stable glycemic control.

Completion pancreatectomy and islet cell autotransplantation as salvage therapy for patients failing previous operative interventions for chronic pancreatitis

“…Several centers, including our own, have even been able to demonstrate the longterm durability of this procedure. 6,11,12 One question that has yet to be addressed is the role that total or completion pancreatectomy and islet cell autotransplantation (CPIAT) has in managing patients with refractory chronic pancreatitis after failed previous pancreatic resection and/or decompression. At our institution, CPIAT is used as salvage therapy for patients with refractory disease after traditional operative intervention.…”

Total pancreatectomy and islet autotransplantation for chronic pancreatitis: spectrum of postoperative CT findings

“…Affirmation of the safety of the procedure along with short and long-term durability of pain relief with narcotic independence, improved quality of life, and insulin independence have been shown in multiple studies [13][14][15][16] with narcotic-independence rate at 73% at 5-year follow-up in one study [17]. A systematic review conducted by Bramis et al, on TPIAT for CP in a total of 296 patients from 72 studies reported a significant reduction in pain as well as an insulin-independence rate ranging from 46% at 5 years to 10% at 8 years [18].…”

Frey procedure for chronic pancreatitis in children: A single center experience

“…This was based on the insightful study of Nealon and Walser [17]. series [18] show that only 38% of children are insulin independent at 1-year follow up, and the percentage decreases with time (27% at more than 5 years). On the other hand, Chinnakotla et al [19] showed good results with statistically improved pain relief in 90% of their patients after TP-IAT (P < 0.001).…”